DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31358 and STOM

DIOPT Version :9

Sequence 1:	NP_001287292.1	Gene:	CG31358 / 41462	FlyBaseID:	FBgn0051358	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_004090.4	Gene:	STOM / 2040	HGNCID:	3383	Length:	288	Species:	Homo sapiens

Alignment Length:	253	Identity:	109/253 - (43%)
Similarity:	176/253 - (69%)	Gaps:	2/253 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VAVFVSWILVLILLPFSLCCCLTIAYEFHRLVIFRLGRI--RSCLGPGLVFLLPCIDSFNTVDIR 93
            :.|..|::..:|..|.|:..|:.|..|:.|.:|||||||  ....||||.|:|||.|||..||:|
Human    33 ILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMR 97

  Fly    94 TDVVNVDPQEMLTKDSVSITVNAVVFYCIYDPINSIIKVDDARDATERISQVTLRNIVGSKGLHE 158
            |...::.|||:||||||:|:|:.||:|.:.:...::..:.:|..||..::|.||||::|:|.|.:
Human    98 TISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQ 162

  Fly   159 LLASRQQLSLEIQQAVAKITERWGVRVERVDLMEISLPSSLERSLASEAEATREARAKIILAEGE 223
            :|:.|::::..:|..:...|:.||::||||::.::.||..|:|::|:||||:||||||:|.||||
Human   163 ILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGE 227

  Fly   224 AKASKALKECSDVMSENQITLQLRHLQILCSMASERRVNVLFPIPLEIMAPFMDGKDS 281
            ..||:||||.|.|::|:...||||:||.|.::|:|:...::||:|::::...:..|.|
Human   228 MNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHS 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31358	NP_001287292.1	PHB	50..204	CDD:214581	65/155 (42%)
CG31358	NP_001287292.1	SPFH_like	74..276	CDD:302763	91/201 (45%)
STOM	NP_004090.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		SPFH_stomatin	73..274	CDD:259801	91/200 (46%)
		Required for homooligomerization	265..273		2/7 (29%)
		Required for lipid raft association	267..269		0/1 (0%)
		Interaction with LANCL1. /evidence=ECO:0000269\|PubMed:9512664	273..287		2/13 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062075at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820