DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31358 and Nphs2

DIOPT Version :9

Sequence 1:	NP_001287292.1	Gene:	CG31358 / 41462	FlyBaseID:	FBgn0051358	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_570841.3	Gene:	Nphs2 / 170672	RGDID:	620461	Length:	383	Species:	Rattus norvegicus

Alignment Length:	246	Identity:	78/246 - (31%)
Similarity:	153/246 - (62%)	Gaps:	2/246 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EKVAVFVSWILVLILLPFSLCCCLTIAYEFHRLVIFRLGRI--RSCLGPGLVFLLPCIDSFNTVD 91
            |.:.|..|.|.:::..|||:..|:.:..|:.|::|||||.:  ....||||.|.|||:|:::.||
  Rat   102 EWLLVLSSLIFIIVTFPFSIWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKVD 166

  Fly    92 IRTDVVNVDPQEMLTKDSVSITVNAVVFYCIYDPINSIIKVDDARDATERISQVTLRNIVGSKGL 156
            :|...:.:...|::|||...:.::||.:|.:.:....:..:.....|.:.:.|.|::.::..:.|
  Rat   167 LRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASLLLSSLAHVSKAIQFLVQTTMKRLLAHRSL 231

  Fly   157 HELLASRQQLSLEIQQAVAKITERWGVRVERVDLMEISLPSSLERSLASEAEATREARAKIILAE 221
            .|:|..|:.::.:::.|:..:|..||::|||.::.::.||:.|:.|||.||||.|:|:.::|.||
  Rat   232 TEILLERKSIAQDVKVALDSVTCVWGIKVERTEIKDVRLPAGLQHSLAVEAEAQRQAKVRVIAAE 296

  Fly   222 GEAKASKALKECSDVMSENQITLQLRHLQILCSMASERRVNVLFPIPLEIM 272
            ||..||::|:..::::|.....:|||:|..|.|:::::...|:.|:|.:::
  Rat   297 GEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTDKPSTVVLPLPFDML 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31358	NP_001287292.1	PHB	50..204	CDD:214581	45/155 (29%)
CG31358	NP_001287292.1	SPFH_like	74..276	CDD:302763	63/199 (32%)
Nphs2	NP_570841.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		SPFH_podocin	122..344	CDD:259809	70/221 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062075at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780