Protein Alignment CG31358 and PHB2

DIOPT Version :9

• Sequence 1: NP_001287292.1
• Gene: CG31358 / 41462
• FlyBaseID: FBgn0051358
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001138303.1
• Gene: PHB2 / 11331
• HGNCID: 30306
• Length: 299
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 65/264 - (24%)
• Similarity: 118/264 - (44%)
• Gaps: 58/264 - (21%)

  Fly    59 HRLVIF-RLGRIR--SCLGPGLVFLLPCIDSFNTVDIRTDVVNVDPQEML----TKD----SVSI 112
            ||.:.| |:|.::  :.|..||.|.:|........|||     ..|:::.    :||    ::|:
Human    47 HRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIR-----ARPRKISSPTGSKDLQMVNISL 106

  Fly   113 TV----NAVVFYCIYDPINSIIKVDDARDATERISQVTLRNIVGSKGLHELLASRQQLSLEIQQA 173
            .|    ||.....:|..:.    :|........|....|:::|......:|:..|.|:||.|::.
Human   107 RVLSRPNAQELPSMYQRLG----LDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRE 167

  Fly   174 VAKITERWGVRVERVDLMEISLPSSLERSLASEA----------------EATREARAKIILAEG 222
            :.:..:.:.:.::.|.:.|:|.  |.|.:.|.||                :|.:|.|.||:.|||
Human   168 LTERAKDFSLILDDVAITELSF--SREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEG 230

  Fly   223 EAKASKALKECSDVMSENQITLQLRHLQILCSMA-----SERRV-----NVLFPIPLEIMAPFMD 277
            ||:|:|.|.|   .:|:|...::||.::...:::     |:.|:     |::..:..|   .|..
Human   231 EAEAAKMLGE---ALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQDE---SFTR 289

  Fly   278 GKDS 281
            |.||
Human   290 GSDS 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31358	NP_001287292.1	PHB	50..204	CDD:214581	36/159 (23%)
		SPFH_like	74..276	CDD:302763	55/239 (23%)
PHB2	NP_001138303.1	Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819	19..49		1/1 (100%)
		SPFH_prohibitin	40..235	CDD:259799	49/198 (25%)
		LC3-interaction region. /evidence=ECO:0000269|PubMed:28017329	121..124		1/2 (50%)
		Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819	150..174		6/23 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810