DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCAF12 and Dcaf12

DIOPT Version :9

Sequence 1:	NP_001262495.1	Gene:	DCAF12 / 41460	FlyBaseID:	FBgn0037980	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	XP_038967331.1	Gene:	Dcaf12 / 682812	RGDID:	1594034	Length:	453	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	183/464 - (39%)
Similarity:	269/464 - (57%)	Gaps:	48/464 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RRAKQRAMRQERRRKPDKPDDFVTYEDSGSDEETPQ--------QQEEVLNTSYNLCDYLRSRES 85
            |:|..|     :|:.|..|       .:|||.:.||        :::.:.....:|..||::||.
  Rat     3 RKAVSR-----KRKAPASP-------GAGSDAQGPQFGWDHSLHKRKRLPPVKRSLVYYLKNREV 55

  Fly    86 GLRDRRS---VNVEYTSRYVLTHDMLRETQISLGYINKVFCSKWLSSRQVVFGTKCNKLLVYDVN 147
            .|::..:   |...|.::.:  ..:|:|.:..||.:||||.|:||:.||||.|||||.|.|.||.
  Rat    56 RLQNETNYSRVLHGYAAQQL--PSLLKEREFHLGTLNKVFASQWLNHRQVVCGTKCNTLFVVDVQ 118

  Fly   148 MRRVDAIPTLSNSRANHPEVQG-GLHAIELSPSRSFLATGARNSSDIAVYRLPTLDPVCVGEGGH 211
            ..::..||.|.:........|| |:|||||:|||:|||||..|.:.:|:||||||||||||:.||
  Rat   119 TGQITKIPILKDREPGGVTQQGCGIHAIELNPSRTFLATGGDNPNSLAIYRLPTLDPVCVGDDGH 183

  Fly   212 RDLIMGMCWLDDQFLVSGSKDSRMALWRINEDHMEFPDGGEEA--CPTFATIHPLSVKEVRTAQ- 273
            :|.|..:.|::|...||||:|..|.||.:.:|.:...|.....  .|.:|.|...::|::....
  Rat   184 KDWIFSIAWINDTMAVSGSRDGSMGLWEVTDDVLTKSDARHNVSPVPVYAHITHKALKDIPKEDT 248

  Fly   274 -----RIRSLCFNKEFKEIAALSLNGYIHIFNAE-TFKQTLSRKLPNCQDNVSIAYHSD-GLYAV 331
                 ::|:|.||.:.||:.|:||:||.|::.|| ...:.||.|||.|::||.:||.|: .:|||
  Rat   249 NPDNCKVRALAFNNKNKELGAVSLDGYFHLWKAENALSKLLSTKLPYCRENVCLAYGSEWSVYAV 313

  Fly   332 GCRSYTILLDAR-TLQTIKKITSRYSGCGIRATSFEGNLLTVGTGLGMLLFYDIRAGKYLESSVN 395
            |.:::...||.| ....:|.:.||..|.|||:.||..:::|||||.|.||||||||.::||..::
  Rat   314 GSQAHVSFLDPRQPSYNVKSVCSRERGSGIRSVSFYEHIITVGTGQGSLLFYDIRAQRFLEERLS 378

  Fly   396 ---------ASRTVALKCSKG-IVYPEDEMDGFQQVKYVP-AIYTHCYDSTRMRLFAAGGPLPAT 449
                     |...:.|...|| :.:.|...:.|..:.:.| |:|||||||:..:||.||||||:.
  Rat   379 ACYGSKPRLAGENLKLTTGKGWLNHDETWRNYFSDIDFFPNAVYTHCYDSSGTKLFVAGGPLPSG 443

  Fly   450 LVGNYAGVW 458
            |.|||||:|
  Rat   444 LHGNYAGLW 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCAF12	NP_001262495.1	WD40	116..388	CDD:295369	129/283 (46%)
		WD40	<121..400	CDD:225201	129/299 (43%)
		WD40 repeat	121..163	CDD:293791	21/41 (51%)
		WD40 repeat	173..210	CDD:293791	26/36 (72%)
		WD40 repeat	216..263	CDD:293791	15/48 (31%)
		WD40 repeat	275..311	CDD:293791	16/36 (44%)
		WD40 repeat	319..353	CDD:293791	12/35 (34%)
Dcaf12	XP_038967331.1	WD40	85..>279	CDD:421866	87/193 (45%)
		WD40 repeat	144..180	CDD:293791	26/35 (74%)
		WD40 repeat	187..233	CDD:293791	14/45 (31%)
		WD40 repeat	255..292	CDD:293791	16/36 (44%)
		WD40 repeat	300..336	CDD:293791	12/35 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1918
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49418
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2768
OMA	1	1.010	-	-		QHG49760
OrthoDB	1	1.010	-	-		D423494at33208
OrthoFinder	1	1.000	-	-		FOG0003107
OrthoInspector	1	1.000	-	-		otm44708
orthoMCL	1	0.900	-	-		OOG6_106884
Panther	1	1.100	-	-	LDO	PTHR19860
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2078
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980