DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCAF12 and dcaf12

DIOPT Version :9

Sequence 1:	NP_001262495.1	Gene:	DCAF12 / 41460	FlyBaseID:	FBgn0037980	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	XP_031752899.1	Gene:	dcaf12 / 394594	XenbaseID:	XB-GENE-1008710	Length:	454	Species:	Xenopus tropicalis

Alignment Length:	464	Identity:	185/464 - (39%)
Similarity:	260/464 - (56%)	Gaps:	51/464 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QRAMRQERRRKPDKPDDFVTYEDSGSD-EETPQQQEEVLNTSYNLCDYLRSRESGLRDRRSVNVE 96
            :||:.::||..|.      |.....|| :.:..:::.:.....:|..||:|||     .:..|..
Frog     3 RRAVSRKRRAAPG------TGPGEQSDWDHSAHKRKRLPPEKKSLVFYLKSRE-----LKPHNDS 56

  Fly    97 YTSRYVLTH------DMLRETQISLGYINKVFCSKWLSSRQVVFGTKCNKLLVYDVNMRRVDAIP 155
            ...|.:..|      .:|.|.:..||.:||||.|:||:.||||.|||||.|.|.||...::..||
Frog    57 SYLRLLRGHAACTLPGILSEREFHLGTLNKVFASQWLNHRQVVCGTKCNTLFVVDVQTGQITKIP 121

  Fly   156 TLSNSR---ANHPEVQGGLHAIELSPSRSFLATGARNSSDIAVYRLPTLDPVCVGEGGHRDLIMG 217
            .|.:..   .:|...  |:||||::|||:.||||..|.:.|||||||||||||||:|||.|.|..
Frog   122 ILKDREPLSGSHQSC--GIHAIEINPSRTLLATGGDNPNSIAVYRLPTLDPVCVGDGGHNDWIFS 184

  Fly   218 MCWLDDQFLVS--------GSKDSRMALWRINEDHMEFPD--GGEEACPTFATIHPLSVKEVRTA 272
            :.|:.|...||        ||:|..||||.:.|:.:...|  .|....|.:|.|...::|::...
Frog   185 IAWISDTMAVSGVSPAGTAGSRDGSMALWEMTEEILSKSDFQHGLSRVPVYAHISHKALKDIPKE 249

  Fly   273 Q------RIRSLCFNKEFKEIAALSLNGYIHIFNAE-TFKQTLSRKLPNCQDNVSIAYHSD-GLY 329
            .      ::|:|.||.:.||:.|:||:|:.|::.|| |..:.||.|||.|::||.:||..: .||
Frog   250 SSNPVNCKVRALAFNSKNKELGAVSLDGFFHLWKAELTLAKLLSTKLPYCRENVCLAYGLEWSLY 314

  Fly   330 AVGCRSYTILLDAR-TLQTIKKITSRYSGCGIRATSFEGNLLTVGTGLGMLLFYDIRAGKYLESS 393
            |||.:::...||.| ..|..|.:..|..|.|||:.||..:::|||||.|.||||||||.::||.|
Frog   315 AVGSQAHVSFLDPRQPPQCAKSVYCREQGSGIRSVSFYEHIVTVGTGQGALLFYDIRAQRFLEDS 379

  Fly   394 VNASRT-------VALKCSKG-IVYPEDEMDGFQQVKYVP-AIYTHCYDSTRMRLFAAGGPLPAT 449
            ..:.|.       :.|...|| :.:.|..|:.|..:...| |:|||||||:..:||.||||||..
Frog   380 TGSCRNSKYKGDLLKLSTGKGWLNHNEMWMNYFSDIDCCPNAVYTHCYDSSGTKLFVAGGPLPTG 444

  Fly   450 LVGNYAGVW 458
            |.|||||:|
Frog   445 LHGNYAGLW 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCAF12	NP_001262495.1	WD40	116..388	CDD:295369	131/293 (45%)
		WD40	<121..400	CDD:225201	132/307 (43%)
		WD40 repeat	121..163	CDD:293791	21/44 (48%)
		WD40 repeat	173..210	CDD:293791	26/36 (72%)
		WD40 repeat	216..263	CDD:293791	17/56 (30%)
		WD40 repeat	275..311	CDD:293791	16/36 (44%)
		WD40 repeat	319..353	CDD:293791	13/35 (37%)
dcaf12	XP_031752899.1	WD40	<80..283	CDD:421866	88/204 (43%)
		WD40 repeat	139..175	CDD:293791	26/35 (74%)
		WD40 repeat	182..238	CDD:293791	17/55 (31%)
		WD40 repeat	258..284	CDD:293791	11/25 (44%)
		WD40 repeat	303..338	CDD:293791	13/34 (38%)
		WD40 repeat	346..384	CDD:293791	21/37 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I1458
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49418
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2681
OMA	1	1.010	-	-		QHG49760
OrthoDB	1	1.010	-	-		D423494at33208
OrthoFinder	1	1.000	-	-		FOG0003107
OrthoInspector	1	1.000	-	-		otm47747
Panther	1	1.100	-	-	LDO	PTHR19860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5427
SonicParanoid	1	1.000	-	-		X2078
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110