DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DCAF12 and Dcaf12l1

DIOPT Version :9

Sequence 1:	NP_001262495.1	Gene:	DCAF12 / 41460	FlyBaseID:	FBgn0037980	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_001101411.1	Gene:	Dcaf12l1 / 313296	RGDID:	1563873	Length:	501	Species:	Rattus norvegicus

Alignment Length:	425	Identity:	167/425 - (39%)
Similarity:	247/425 - (58%)	Gaps:	53/425 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 NLCDYLRSRESGL----------RDRRSVNVEYTSRYVLTHDMLRETQISLGYINKVFCSKWLSS 129
            ::.:||:.|..|.          .|.||..|      :...::|||.|::||.:||||.|:||::
  Rat    88 SMVNYLKGRALGADGHPGFAGFEGDLRSYGV------LRLPELLRERQLTLGPLNKVFASQWLNA 146

  Fly   130 RQVVFGTKCNKLLVYDVNMRRVDAIPTLSNSRANHPEVQG-----GLHAIELSPSRSFLATGARN 189
            ||||.|||||.|.|.||....:..||.:   |...|::..     |:||:||:||::.||||..|
  Rat   147 RQVVCGTKCNTLFVVDVKTDHIMRIPLM---RDRVPDLSRGPPSCGIHAVELNPSKTLLATGGEN 208

  Fly   190 SSDIAVYRLPTLDPVCVGE-GGHRDLIMGMCWLDDQFLVSGSKDSRMALWRINEDHME-----FP 248
            .:.:|||:||||||||:|: .||||.|..:.|:.|...||||:|..:|||:::.|...     ..
  Rat   209 PNSLAVYQLPTLDPVCLGDCQGHRDWIFAIAWMSDTVAVSGSRDGTVALWKVDPDMFNGSIAWHK 273

  Fly   249 DGGEEACPTFATIHPLSVKEVRTA------QRIRSLCFNKEFKEIAALSLNGYIHIFNA-ETFKQ 306
            |.|   .|.:|.|.|..::.:..|      :::|:|.|:.:.:|:.|:||:||.|::.| .:..:
  Rat   274 DAG---LPVYAHISPTDMEAIPKATTNPGNRKVRALAFSNKNQELGAVSLDGYFHLWKARSSLSR 335

  Fly   307 TLSRKLPNCQDNVSIAYHSD-GLYAVGCRSYTILLDART-LQTIKKITSRYSGCGIRATSFEGNL 369
            .||.:||.|::||.:.|..: .|||||.:|:...||.|. .|.|..:.||..|.|:|:.|...::
  Rat   336 LLSLRLPYCRENVCLTYCDEFSLYAVGSQSHVSFLDLRQGQQNIPPLCSREGGTGVRSLSVHQHI 400

  Fly   370 LTVGTGLGMLLFYDIRAGKYLE--SSVN-------ASRTVALKCSKGIVYPEDEMDGF-QQVKYV 424
            :|||||.|.||||||||.|:||  |:.|       :.|.:.|.|..|.:..:|.::.: ..|:..
  Rat   401 VTVGTGHGSLLFYDIRAQKFLEERSAANPDMFPVPSGRKLKLTCGSGWINQDDLLENYVAGVEDF 465

  Fly   425 P-AIYTHCYDSTRMRLFAAGGPLPATLVGNYAGVW 458
            | |:|||||:...|:||..||||.:.|.|||||:|
  Rat   466 PNALYTHCYNWPEMKLFVGGGPLASGLHGNYAGLW 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCAF12	NP_001262495.1	WD40	116..388	CDD:295369	122/291 (42%)
		WD40	<121..400	CDD:225201	125/307 (41%)
		WD40 repeat	121..163	CDD:293791	21/41 (51%)
		WD40 repeat	173..210	CDD:293791	22/37 (59%)
		WD40 repeat	216..263	CDD:293791	16/51 (31%)
		WD40 repeat	275..311	CDD:293791	13/36 (36%)
		WD40 repeat	319..353	CDD:293791	13/35 (37%)
Dcaf12l1	NP_001101411.1	WD40	133..>327	CDD:295369	82/199 (41%)
		WD40 repeat	138..180	CDD:293791	21/44 (48%)
		WD40	<190..428	CDD:225201	100/240 (42%)
		WD40 repeat	191..230	CDD:293791	23/38 (61%)
		WD40 repeat	235..266	CDD:293791	12/30 (40%)
		WD40 repeat	268..297	CDD:293791	7/31 (23%)
		WD40 repeat	303..340	CDD:293791	13/36 (36%)
		WD40 repeat	348..386	CDD:293791	14/37 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2768
OMA	1	1.010	-	-		QHG49760
OrthoDB	1	1.010	-	-		D423494at33208
OrthoFinder	1	1.000	-	-		FOG0003107
OrthoInspector	1	1.000	-	-		otm44708
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19860
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2078
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.080