DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DCAF12 and Dcaf12l1

DIOPT Version :9

Sequence 1:	NP_001262495.1	Gene:	DCAF12 / 41460	FlyBaseID:	FBgn0037980	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_001177647.1	Gene:	Dcaf12l1 / 245404	MGIID:	2444462	Length:	501	Species:	Mus musculus

Alignment Length:	443	Identity:	172/443 - (38%)
Similarity:	254/443 - (57%)	Gaps:	55/443 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GSDEETPQQQEEVLNTSYNLCDYLRSRESGL----------RDRRSVNVEYTSRYVLTHDMLRET 111
            ||...|.:.:..|.:.|  :.:||:.|..|.          .|.||..|      :...::|||.
Mouse    72 GSMLLTKRPRRPVAHLS--MVNYLKGRALGADGHPGLAGFEGDLRSYGV------LRLPELLRER 128

  Fly   112 QISLGYINKVFCSKWLSSRQVVFGTKCNKLLVYDVNMRRVDAIPTLSNSRANHPEVQG-----GL 171
            |::||.:||||.|:||::||||.|||||.|.|.||....:..||.:   |...|::..     |:
Mouse   129 QLTLGPLNKVFASQWLNARQVVCGTKCNTLFVVDVKTDHIMRIPLM---RDRVPDLSRGPPSCGI 190

  Fly   172 HAIELSPSRSFLATGARNSSDIAVYRLPTLDPVCVGE-GGHRDLIMGMCWLDDQFLVSGSKDSRM 235
            ||:||:||::.||||..|.:.:|||:||||||||:|: .||||.|..:.|:.|...||||:|..:
Mouse   191 HAVELNPSKTLLATGGENPNSLAVYQLPTLDPVCLGDCQGHRDWIFAIAWMSDTVAVSGSRDGTV 255

  Fly   236 ALWRINEDHME-----FPDGGEEACPTFATIHPLSVKEVRTA------QRIRSLCFNKEFKEIAA 289
            |||:::.|...     ..|.|   .|.:|.|.|..::.:..|      :::|:|.|:.:.:|:.|
Mouse   256 ALWKVDPDMFNGSIAWHKDAG---LPVYAHISPTDMEAIPKATTNPGNRKVRALAFSNKNQELGA 317

  Fly   290 LSLNGYIHIFNA-ETFKQTLSRKLPNCQDNVSIAYHSD-GLYAVGCRSYTILLDART-LQTIKKI 351
            :||:||.|::.| .:..:.||.:||.|::||.:.|..: .|||||.:|:...||.|. .|.|..:
Mouse   318 VSLDGYFHLWKARSSLSRLLSLRLPYCRENVCLTYCDEFSLYAVGSQSHVSFLDLRQGQQNIPPL 382

  Fly   352 TSRYSGCGIRATSFEGNLLTVGTGLGMLLFYDIRAGKYLE--SSVN-------ASRTVALKCSKG 407
            .||..|.|:|:.|...:::|||||.|.||||||||.|:||  |:.|       :.|.:.|.|..|
Mouse   383 CSREGGTGVRSLSVHQHIVTVGTGHGSLLFYDIRAQKFLEERSAANPDMFPVPSGRKLKLTCGSG 447

  Fly   408 IVYPEDEMDGF-QQVKYVP-AIYTHCYDSTRMRLFAAGGPLPATLVGNYAGVW 458
            .:..:|.::.: ..|:..| |:|||||:...|:||..||||.:.|.|||||:|
Mouse   448 WINQDDLLENYVAGVEDFPNALYTHCYNWPEMKLFVGGGPLASGLHGNYAGLW 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCAF12	NP_001262495.1	WD40	116..388	CDD:295369	122/291 (42%)
		WD40	<121..400	CDD:225201	125/307 (41%)
		WD40 repeat	121..163	CDD:293791	21/41 (51%)
		WD40 repeat	173..210	CDD:293791	22/37 (59%)
		WD40 repeat	216..263	CDD:293791	16/51 (31%)
		WD40 repeat	275..311	CDD:293791	13/36 (36%)
		WD40 repeat	319..353	CDD:293791	13/35 (37%)
Dcaf12l1	NP_001177647.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67
		WD40 repeat	138..180	CDD:293791	21/44 (48%)
		WD 1	185..225		22/39 (56%)
		WD40	<190..428	CDD:225201	100/240 (42%)
		WD40 repeat	191..230	CDD:293791	23/38 (61%)
		WD 2	230..268		16/37 (43%)
		WD40 repeat	235..266	CDD:293791	12/30 (40%)
		WD40 repeat	268..297	CDD:293791	7/31 (23%)
		WD 3	298..337		11/38 (29%)
		WD40 repeat	303..340	CDD:293791	13/36 (36%)
		WD40 repeat	348..386	CDD:293791	14/37 (38%)
		WD 4	384..423		22/38 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28IW7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2628
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49760
OrthoDB	1	1.010	-	-		D423494at33208
OrthoFinder	1	1.000	-	-		FOG0003107
OrthoInspector	1	1.000	-	-		otm42641
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19860
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2078
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.940