DRSC/TRiP Functional Genomics Resources

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Protein Alignment DCAF12 and DCAF12L1

DIOPT Version :9

Sequence 1:NP_001262495.1 Gene:DCAF12 / 41460 FlyBaseID:FBgn0037980 Length:459 Species:Drosophila melanogaster
Sequence 2:NP_848565.2 Gene:DCAF12L1 / 139170 HGNCID:29395 Length:463 Species:Homo sapiens


Alignment Length:465 Identity:187/465 - (40%)
Similarity:263/465 - (56%) Gaps:45/465 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 AMRQERRRKPDKPDDFVTYEDSGS------DEETP----QQQEEVLNTSYNLCDYLRSRE-SGLR 88
            |.:|...||...|......|.|.|      |.|.|    :|:...  |..::..||:.|| .|..
Human     2 AQQQTGSRKRKAPAVEADAESSPSQGLAAADGEGPLLLKRQRRPA--TYRSMAHYLKVREVGGWG 64

  Fly    89 DRRSVNVEYTSR-YVLTH--DMLRETQISLGYINKVFCSKWLSSRQVVFGTKCNKLLVYDVNMRR 150
            ..|....:...| |.:..  ::|.|.|:.||.:||||.|:||:|||||.|||||.|.|.||....
Human    65 PARLQGFDGELRGYAVQRLPELLTERQLELGTVNKVFASQWLNSRQVVCGTKCNTLFVVDVESGH 129

  Fly   151 VDAIPTLSNSRAN-HPEVQG-GLHAIELSPSRSFLATGARNSSDIAVYRLPTLDPVCVGE-GGHR 212
            :..||.|.:|.|. ..:.|| |:|||||:||::.||||..|.:.:|:|:||:|||:|:|: .||:
Human   130 IARIPLLRDSEARLAQDQQGCGIHAIELNPSKTLLATGGENPNSLAIYQLPSLDPLCLGDRHGHK 194

  Fly   213 DLIMGMCWLDDQFLVSGSKDSRMALWRINEDHMEFPD----GGEEACPTFATIHPLSVKEVRTA- 272
            |.|..:.||.|...||||:|..:||||::.|  :|.|    ..|...|.:|.|.|..|:.:..| 
Human   195 DWIFAVAWLSDTVAVSGSRDGTVALWRMDPD--KFDDTVAWHSEVGLPVYAHIRPRDVEAIPRAI 257

  Fly   273 -----QRIRSLCFNKEFKEIAALSLNGYIHIFNA-ETFKQTLSRKLPNCQDNVSIAYHSD-GLYA 330
                 :::|:|....:.:|:.|:||:||.|::.| ....:.||.:||..:|||.:.|..| .:||
Human   258 INPSNRKVRALACGGKNQELGAVSLDGYFHLWKAGSALSRLLSIRLPYFRDNVCLTYCDDMSVYA 322

  Fly   331 VGCRSYTILLDAR-TLQTIKKITSRYSGCGIRATSFEGNLLTVGTGLGMLLFYDIRAGKYLE--- 391
            ||..|:...||.| ..|.|:.:.||..|.|:|:.||..:::|||||.|.|||||:||.|:||   
Human   323 VGSHSHVSFLDLRQDQQNIRPLCSREGGTGVRSLSFYRHIITVGTGQGSLLFYDVRAQKFLEERA 387

  Fly   392 ------SSVNASRTVALKCSKGIVYPED-EMDGFQQVKYVP-AIYTHCYDSTRMRLFAAGGPLPA 448
                  ||..|.|.:.|.|.:|.:...| .::.|..::..| |:|||||:...|:||.|||||||
Human   388 SATLESSSGPARRKLRLACGRGWLNHNDFWVNYFGGMEVFPNALYTHCYNWPEMKLFVAGGPLPA 452

  Fly   449 TLVGNYAGVW 458
            .|.|||||:|
Human   453 GLHGNYAGLW 462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DCAF12NP_001262495.1 WD40 116..388 CDD:295369 126/287 (44%)
WD40 <121..400 CDD:225201 130/303 (43%)
WD40 repeat 121..163 CDD:293791 23/41 (56%)
WD40 repeat 173..210 CDD:293791 20/37 (54%)
WD40 repeat 216..263 CDD:293791 19/50 (38%)
WD40 repeat 275..311 CDD:293791 12/36 (33%)
WD40 repeat 319..353 CDD:293791 13/35 (37%)
DCAF12L1NP_848565.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35 9/32 (28%)
WD 1 87..137 28/49 (57%)
WD40 89..>227 CDD:295369 71/139 (51%)
WD40 repeat 100..145 CDD:293791 24/44 (55%)
WD 2 138..184 22/45 (49%)
WD40 <152..417 CDD:225201 107/266 (40%)
WD40 repeat 153..192 CDD:293791 21/38 (55%)
WD 3 185..252 27/68 (40%)
WD40 repeat 197..222 CDD:293791 12/24 (50%)
WD40 repeat 230..259 CDD:293791 7/28 (25%)
WD 4 253..297 11/43 (26%)
WD40 repeat 265..299 CDD:293791 10/33 (30%)
WD 5 298..341 18/42 (43%)
WD40 repeat 307..348 CDD:293791 16/40 (40%)
WD 6 342..376 16/33 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 307 1.000 Domainoid score I1355
eggNOG 1 0.900 - - E1_28IW7
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 307 1.000 Inparanoid score I2628
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49760
OrthoDB 1 1.010 - - D423494at33208
OrthoFinder 1 1.000 - - FOG0003107
OrthoInspector 1 1.000 - - otm40570
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19860
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2078
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.940

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