Protein Alignment GCC185 and GCC2

DIOPT Version :9

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: XP_006712933.1
• Gene: GCC2 / 9648
• HGNCID: 23218
• Length: 1687
• Species: Homo sapiens
• Alignment Length: 1507
• Identity: 350/1507 - (23%)
• Similarity: 607/1507 - (40%)
• Gaps: 468/1507 - (31%)

  Fly     4 ASPRETQKNPNPIEAL----------SKDEIISKYK-GLLNIAKKAKQAKDE------LTEENHR 51
            ||.:|.:...|.:..|          |:..|..||: .|.|:.|....|..:      |.:||..
Human   264 ASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTF 328

  Fly    52 LKDALKRAAEKQSSLPAMQEMVQDFTDKNLILTEEV---NNLKRKTKEDADRL-TQFEIENESL- 111
            ::..:.   ||...|   ::.:::...::.||.:||   ||||.|.:.||..: .:|..|.|.|
Human   329 VEQVVN---EKVKHL---EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLE 387

  Fly   112 ---------KRQLGRLSDENDALLANVDR-----MEKAMQQVNALGNEQRKNLELLEVDIAKIKE 162
                     |.:.|.:.::..:.||.:::     :|:..::|.:|..:.:|  |:.|::...:.:
Human   388 FKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQK--EISELNETFLSD 450

  Fly   163 AEAENASLRQQVATMEEESSVLQQK-------YQNIKE----LNSEQ-------RKKFNSLK-DR 208
            :|.|..:|..::..::|:...|||:       |::::|    |.:|.       .::|.|:| .:
Human   451 SEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQ 515

  Fly   209 FIDVH---RKLKNLKECKCVLLET-------------QHEYAASV--------SKWQVEIIKASQ 249
            ..|||   :||:.....|..||||             |.|....:        .|..|.::..||
Human   516 ASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQ 580

  Fly   250 L------LCAKMASLQAENE----KLKLNNGKSDN------------------NPQTIDTGIDRK 286
            .      |..|:.||..|.:    |||.::.:.||                  ..|||..   ..
Human   581 RDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQY---NS 642

  Fly   287 RLLQRVQEM-DRLAKIVKQKQKNQRSNLNVEYLLKKITALEELAVIIKQQHRIDKEQLISVTKE- 349
            .|.|:|.|: ..|.:.:|:|.:|.:   .:|.|:.::..|.|           |||.|.:..|.
Human   643 ELEQKVNELTGGLEETLKEKDQNDQ---KLEKLMVQMKVLSE-----------DKEVLSAEVKSL 693

  Fly   350 -QENT------KNHARNLNVSLFQTK-------LDQMQNLVKVIAKERDNQQRKLQE-------- 392
             :||.      |..:|:|.|.|.|.:       :.|::..::::.:|:||..:.|:.
Human   694 YEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFV 758

  Fly   393 ---------------------------LEAICIELRQHNEDLLTRYHLKEQEHGELLTEMRELNE 430
                                       |:|:...|.:.||:.......::::..||..|::.|.|
Human   759 KTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQE 823

  Fly   431 ALKGRGDAISRLQEQHEAE-VKRQRDLEAQLSNSQQAAQEKLQKIK-----------QLQSRVEE 483
            ....:.:.:..|...:|.| |..:::|| ::.:.::|.|..|.::|           .|..:|||
Human   824 ESVVQCEELKSLLRDYEQEKVLLRKELE-EIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE 887

  Fly   484 LEQANADAQ-----------------------------------SDVLSTSTISRAEELSRLREL 513
            :.|..:.::                                   .|.|:.|...:.:.||.::||
Human   888 VSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 952

  Fly   514 DEGY----------EEKYHKLRAIAAKLKKKLQEQTQQLNEMEQSGALKEELEAIKLAQAQLQQD 568
            :|..          |||.:|::.:|.|.||:|.      :..:::..:|||||:::..:.||...
Human   953 EEKIENLEKECKEKEEKINKIKLVAVKAKKELD------SSRKETQTVKEELESLRSEKDQLSAS 1011

  Fly   569 LN--AARAENQKLKSKEKVKHSSVLNLEIEAA---EKSLSEVSAKLTAKSSELEAVK-------- 620
            :.  ...||:.|....|..|.|..|::|.|.|   |..:.:::.:|...:.:.|.:.
Human  1012 MRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLA 1076

  Fly   621 ----------------------ESLASKENTIVQLRKEIAILEEAKNGEAAHSLELKEQIDRMQV 663
                                  :::..||....:|:||..|.|.|........|:::.|..:.|:
Human  1077 RIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQL 1141

  Fly   664 Q---------VKDA----------------VHSKQQALT--QNK--DLEHGVEQAKLEAEQLR-- 697
            |         .|||                :....|.||  .||  |||..::..|.:.|.|:
Human  1142 QKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEE 1206

  Fly   698 -LQLSESAQQYESKLNTATQQLLSQTQ----------------------ELE----------MHL 729
             ..|..|.||||.| ||..:|||.:|:                      |||          :.|
Human  1207 ITSLQSSVQQYEEK-NTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQL 1270

  Fly   730 AE--------QKRLETALRNAERAL-----------EDLRV----------EYTEYKLKAQSVLR 765
            ||        .:.|:|:....:|.|           |:.|.          |:..||::..:||:
Human  1271 AEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLK 1335

  Fly   766 KNQNK--------GSNREQE-----LEEELVALRESERNLRASNDGRAARLAQLDSQIEELRQDN 817
            :.:||        |:.:|:|     :::..:.|::|:.||:.:    .:.|..|.|:.:.|.:.:
Human  1336 QQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQIN----VSELQTLQSEHDTLLERH 1396

  Fly   818 TDLQKRSKELVSLVDELRQ-------QNDLLSLENQR---QLQFQHDLMQ-QHRQQVDELDAGHQ 871
               .|..:|.||...|||:       :|.::..|:.:   ||..|::::: ..|.||..|...|:
Human  1397 ---NKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHR 1458

  Fly   872 LQLTQVQEQLE--EAQKMQANVSQHTTASAASVDTS----PEQAKIDYLLMDHETGLDGHAGDVS 930
            ..:..:|:||.  |||..|.. ::.||.|..|...|    .|:...|..|:|
Human  1459 KTVETLQQQLSKMEAQLFQLK-NEPTTRSPVSSQQSLKNLRERRNTDLPLLD------------- 1509

  Fly   931 LAQLAAQRKISTASRRSHDFMPLDELLNTSMNQITSDT--VTTISNFGRSVSQ-QEDEEAEMAA- 991
                     :.|.:|...:.|.            |:||  |::.|.:.:|:.| ....|.::..
Human  1510 ---------MHTVTREEGEGME------------TTDTESVSSASTYTQSLEQLLNSPETKLEPP 1553

  Fly   992 --RGDFSVQSAQLQATKE----RLSIQESRVKHLTALLAENEQDLAKLTQMNDMLKEELRRQERS 1050
              ..:|         |||    :||.......||..||.|.|...|.|.:...:||.|:||.||:
Human  1554 LWHAEF---------TKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN 1609

  Fly  1051 EEREQHMHNSEYLKNVFLKFLTLNNVDERQRLVPVLNTILRLSRNEMEMLNCVAKGQKVSADGSS 1115
            :|||:...|.||||||.|:|:.|....||:||:||:||:|:||..|...|..||:|::.:|..||
Human  1610 QEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSS 1674

  Fly  1116 RSWTGFLTAWSG 1127
             .|..:|.:|||
Human  1675 -GWASYLHSWSG 1685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	236/1122 (21%)
		TMPIT	458..>548	CDD:285135	26/145 (18%)
		GRIP	1058..1100	CDD:279767	22/41 (54%)
GCC2	XP_006712933.1	Smc	44..956	CDD:224117	150/717 (21%)
		SMC_prok_B	703..1481	CDD:274008	166/793 (21%)
		Rab_bind	1551..1615	CDD:293309	24/72 (33%)
		GRIP	1617..1659	CDD:279767	22/41 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149775
Domainoid	1	1.000	46	1.000	Domainoid score	I12111
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	222	1.000	Inparanoid score	I3550
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007273
OrthoInspector	1	1.000	-	-		otm41740
orthoMCL	1	0.900	-	-		OOG6_105134
Panther	1	1.100	-	-	LDO	PTHR18902
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5428
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780