Protein Alignment GCC185 and NUP2

DIOPT Version :10

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: NP_013439.1
• Gene: NUP2 / 851048
• SGDID: S000004327
• Length: 720
• Species: Saccharomyces cerevisiae
• Alignment Length: 491
• Identity: 83/491 - (16%)
• Similarity: 187/491 - (38%)
• Gaps: 89/491 - (18%)

  Fly   557 AIKLAQAQLQQDLNAARAENQKLKSKEKVKHSSVLNLEIEAAEKSLSEVSAKLTAKSSEL-EAVK 620
            |.::|.||:|::...:...:..:....||..|:|:|....|..|.........:|||.|. :|..
Yeast     2 AKRVADAQIQRETYDSNESDDDVTPSTKVASSAVMNRRKIAMPKRRMAFKPFGSAKSDETKQASS 66

  Fly   621 ESLASKENTIVQLRKEIAILEEAKNGEAAHSLELKEQID----------------RMQVQVKDAV 669
            .|..::.:...:.:.:.:...|:.:...|.:|:.|.::|                |.::.:|:.:
Yeast    67 FSFLNRADGTGEAQVDNSPTTESNSRLKALNLQFKAKVDDLVLGKPLADLRPLFTRYELYIKNIL 131

  Fly   670 HSKQQAL---TQNKDLEHGVEQAKLEAEQLRLQLSESAQQYESKLNTATQQLLSQTQELEMHLAE 731
            .:..:::   ||.|.  :..:.||:|..|   :.|:|:.:.|.|:......:.::....:...:.
Yeast   132 EAPVKSIENPTQTKG--NDAKPAKVEDVQ---KSSDSSSEDEVKVEGPKFTIDAKPPISDSVFSF 191

  Fly   732 QKRLETALRNAERALEDLRVEYTEYKLK---AQSVLRKNQNKGSNREQELEEELVALRESERNLR 793
            ..:.|...::...:..|:.::..|:|..   :..|.:.|.:...|.           :::|.|.:
Yeast   192 GPKKENRKKDESDSENDIEIKGPEFKFSGTVSSDVFKLNPSTDKNE-----------KKTETNAK 245

  Fly   794 ASNDGRAARLAQLDSQIEELRQDNTDLQKRSKELVSLVDELRQQNDLLSLENQRQLQFQHDLMQQ 858
            ..:...|.               :|..|.:||..:||.:..:     .:::|..:.:.......:
Yeast   246 PFSFSSAT---------------STTEQTKSKNPLSLTEATK-----TNVDNNSKAEASFTFGTK 290

  Fly   859 HRQQVDELDAGHQLQLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPEQAKIDYLLMDHETGLD 923
            |..................:..||::.....:    ||....:.:.|...:|       .|...|
Yeast   291 HAADSQNNKPSFVFGQAAAKPSLEKSSFTFGS----TTIEKKNDENSTSNSK-------PEKSSD 344

  Fly   924 GHAGDVSLAQLAAQRKISTASRRSHDF-MPLDELLNTSMNQITSDTVTTISNFG------RSVSQ 981
            .:..:.|.:.....:....||:.|..| :|     |:|.|    :|...:.:||      :..||
Yeast   345 SNDSNPSFSFSIPSKNTPDASKPSFSFGVP-----NSSKN----ETSKPVFSFGAATPSAKEASQ 400

  Fly   982 QEDEE--AEMAARGDFSVQSAQLQATKERLSIQESR 1015
            ::|..  .:.:::..|::.| .....||:.|.::|:
Yeast   401 EDDNNNVEKPSSKPAFNLIS-NAGTEKEKESKKDSK 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	PRK03918	<33..559	CDD:235175	1/1 (100%)
		Smc	<357..>920	CDD:440809	60/385 (16%)
		Grip	1057..1103	CDD:197860
NUP2	NP_013439.1	NUP50	2..71	CDD:462629	18/68 (26%)
		PRK08581	233..>486	CDD:236304	41/255 (16%)
		RanBD	588..715	CDD:197549