DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GCC185 and NUP2

DIOPT Version :9

Sequence 1:	NP_001097755.1	Gene:	GCC185 / 41459	FlyBaseID:	FBgn0037979	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	NP_013439.1	Gene:	NUP2 / 851048	SGDID:	S000004327	Length:	720	Species:	Saccharomyces cerevisiae

Alignment Length:	491	Identity:	83/491 - (16%)
Similarity:	187/491 - (38%)	Gaps:	89/491 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   557 AIKLAQAQLQQDLNAARAENQKLKSKEKVKHSSVLNLEIEAAEKSLSEVSAKLTAKSSEL-EAVK 620
            |.::|.||:|::...:...:..:....||..|:|:|....|..|.........:|||.|. :|..
Yeast     2 AKRVADAQIQRETYDSNESDDDVTPSTKVASSAVMNRRKIAMPKRRMAFKPFGSAKSDETKQASS 66

  Fly   621 ESLASKENTIVQLRKEIAILEEAKNGEAAHSLELKEQID----------------RMQVQVKDAV 669
            .|..::.:...:.:.:.:...|:.:...|.:|:.|.::|                |.::.:|:.:
Yeast    67 FSFLNRADGTGEAQVDNSPTTESNSRLKALNLQFKAKVDDLVLGKPLADLRPLFTRYELYIKNIL 131

  Fly   670 HSKQQAL---TQNKDLEHGVEQAKLEAEQLRLQLSESAQQYESKLNTATQQLLSQTQELEMHLAE 731
            .:..:::   ||.|.  :..:.||:|..|   :.|:|:.:.|.|:......:.::....:...:.
Yeast   132 EAPVKSIENPTQTKG--NDAKPAKVEDVQ---KSSDSSSEDEVKVEGPKFTIDAKPPISDSVFSF 191

  Fly   732 QKRLETALRNAERALEDLRVEYTEYKLK---AQSVLRKNQNKGSNREQELEEELVALRESERNLR 793
            ..:.|...::...:..|:.::..|:|..   :..|.:.|.:...|.           :::|.|.:
Yeast   192 GPKKENRKKDESDSENDIEIKGPEFKFSGTVSSDVFKLNPSTDKNE-----------KKTETNAK 245

  Fly   794 ASNDGRAARLAQLDSQIEELRQDNTDLQKRSKELVSLVDELRQQNDLLSLENQRQLQFQHDLMQQ 858
            ..:...|.               :|..|.:||..:||.:..:     .:::|..:.:.......:
Yeast   246 PFSFSSAT---------------STTEQTKSKNPLSLTEATK-----TNVDNNSKAEASFTFGTK 290

  Fly   859 HRQQVDELDAGHQLQLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPEQAKIDYLLMDHETGLD 923
            |..................:..||::.....:    ||....:.:.|...:|       .|...|
Yeast   291 HAADSQNNKPSFVFGQAAAKPSLEKSSFTFGS----TTIEKKNDENSTSNSK-------PEKSSD 344

  Fly   924 GHAGDVSLAQLAAQRKISTASRRSHDF-MPLDELLNTSMNQITSDTVTTISNFG------RSVSQ 981
            .:..:.|.:.....:....||:.|..| :|     |:|.|    :|...:.:||      :..||
Yeast   345 SNDSNPSFSFSIPSKNTPDASKPSFSFGVP-----NSSKN----ETSKPVFSFGAATPSAKEASQ 400

  Fly   982 QEDEE--AEMAARGDFSVQSAQLQATKERLSIQESR 1015
            ::|..  .:.:::..|::.| .....||:.|.::|:
Yeast   401 EDDNNNVEKPSSKPAFNLIS-NAGTEKEKESKKDSK 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	46/278 (17%)
		TMPIT	458..>548	CDD:285135
		GRIP	1058..1100	CDD:279767
NUP2	NP_013439.1	NUP50	3..70	CDD:401019	17/66 (26%)
		PRK08581	233..>486	CDD:236304	41/255 (16%)
		RanBD	588..715	CDD:197549
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900