Protein Alignment GCC185 and RGPD2

DIOPT Version :10

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: XP_054199708.1
• Gene: RGPD2 / 729857
• HGNCID: 32415
• Length: 1913
• Species: Homo sapiens
• Alignment Length: 1623
• Identity: 276/1623 - (17%)
• Similarity: 516/1623 - (31%)
• Gaps: 608/1623 - (37%)

  Fly    44 ELTEENHRLKDALKRAAEKQ-----------------------SSLPAMQEMVQDFTDKNLILTE 85
            ||...|.|||||:.|..|.:                       .||..::....|:...|..|..
Human   329 ELYRSNKRLKDAVARCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLL 393

  Fly    86 EVNNL------KRKTKEDADRLTQFEIENESLKRQLGRLSDENDALLANVDRME----------- 133
            ...||      .|..:|..:.|..|:...:|.|..||    .||.|.|....|:
Human   394 AYANLMLLTLSTRDVQESRELLESFDSALQSAKSSLG----GNDELSATFLEMKGHFYMHAGSLL 454

  Fly   134 ------------KAMQQVNAL-----------------GNEQRKNLELLEVDIAK------IKEA 163
                        :|:.::.||                 |...:..||::..|...      :..:
Human   455 LKMGQHGNNVQWQALSELAALCYVIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLNLS 519

  Fly   164 EAENASLRQQVATMEEES--SVLQQKYQNIKELNSEQRKKFNSLKD-RFIDVHR-KLKNLKECKC 224
            ..:...|::.|.|...:|  |||   |..:....|.:...|....| ..|||.. :|::|.....
Human   520 RGKQDFLKEVVETFANKSGQSVL---YNALFSSQSSKDTSFLGSDDIGNIDVQEPELEDLARYDV 581

  Fly   225 VLLET-----QH-----------EYAASVSKWQVEII------------KASQLLC--------- 252
            ..::.     ||           .....:.||..::.            .|.:.:|
Human   582 GAIQAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLL 646

  Fly   253 --AKMASLQAENEKLKLNNGKSDNNPQTIDTGIDRKRLLQRVQE-MDRLAKIVKQKQ---KNQRS 311
              ...:.||.   |.|.|:..|...|..:...:.::...:|.:. .|.:..::.:|.   .:...
Human   647 GVVYTSHLQL---KEKCNSHHSSYQPLCLPLPVCKRLCTERQKSWWDAVCTLIHRKAVPGNSAEL 708

  Fly   312 NLNVEYLLKKITALEELAVIIKQQHRIDKEQLISVTKEQENTKNHARNLNVSLFQTKL------- 369
            .|.|::.:..:.|        :::|.:....|:...|   ..:...|.||.|..|.:.
Human   709 RLVVQHEINTLRA--------QEKHGLQPALLVHWAK---CLQKMGRGLNSSYDQQEYIGRSVHY 762

  Fly   370 -DQMQNLVKVIAKER-----DNQQRKLQELEAICIELRQHNEDLLTRYHLKEQEHGELLTEMREL 428
             .::..|:|:|.|..     |...:....::....|:.::.||....:.:.:..||.:...:...
Human   763 WKKVLPLLKIIKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVHGNIEDAVTAF 827

  Fly   429 NEALKG------------------RGDAISRLQEQHEAE--VKRQRDLEAQL---SNSQQAAQEK 470
             |::|.                  ..||:.. :||.|.:  :::.||...::   |:|..:..:|
Human   828 -ESIKSVVSYWNLALIFHRKAEDIENDAVFP-EEQEECKNYLRKTRDYLIKIIDDSDSNLSVVKK 890

  Fly   471 ----LQKIKQ-LQSRVEELEQ-------------ANADAQ------------------------- 492
                |:.:|: |:|.::|||.             .|||::
Human   891 LPVPLESVKEMLKSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPKT 955

  Fly   493 ----------------SDVLSTSTISRAEELSRLR---------ELDEGYE--EKYH-------- 522
                            .:|.:.:.::.::..||.|         .:.:||:  :.:|
Human   956 PPRWAEDQNSLRKMICQEVKAITKLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHGAPLTVAT 1020

  Fly   523 -----------------KLRAIAAKLKKKLQEQTQQLNEMEQSGALKEELEAIKLAQAQLQQDLN 570
                             .||..|.....|....|:          .|...|...:|.:.......
Human  1021 TGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTE----------FKSTKEGFSIAVSADGFKFG 1075

  Fly   571 AARAENQKLKSKEKVKHSSVLNLEIEAAEKS-----LSEVSAKLT----AKSSELEAVK------ 620
            .:...||:.||::.:::.:....:..:.:|:     ..:.|:..|    |||:..|..:
Human  1076 ISEPGNQEKKSEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQFGKKDP 1140

  Fly   621 -----------------ESLASKENT-----------------------IVQLRKEIAILEEAKN 645
                             ..:|:|.||                       :||:.:::.::...:.
Human  1141 NFKGFSGAGEKLFSSQCGKMANKANTSGDFEKDDDACKTEDSDDIHFEPVVQMPEKVELVTGEEG 1205

  Fly   646 GEAAHSLELKEQIDRMQVQV--------------KDAVHSKQQAL-----------------TQN 679
            .:..:|..:|  :.|...::              |:.|:.|.:.|                 |.|
Human  1206 EKVLYSQGVK--LFRFDAEISQWKERGLGNLKILKNEVNGKPRMLMRRDQVLKVCANHWITTTMN 1268

  Fly   680 ---------------KDLEHGVEQAKLEAEQLRLQLSESAQQYESKLNTATQQLLSQTQELEMHL 729
                           .|...|  .||||....:.:..|.|::::.|.....:.||....:....|
Human  1269 LKPLSGSDRAWMWLASDFSDG--DAKLERLAAQFKTPELAEEFKQKFEECQRLLLDIPLQTPHKL 1331

  Fly   730 AEQKRLETALRNAERALEDLRVEYTEYKLKAQSVLRKNQNKGS-----------------NREQE 777
            .:..|....::.||.....|: ::..:....|:.:.:.:||||                 |....
Human  1332 VDTGRAAKLIQRAEEMKSGLK-DFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGPT 1395

  Fly   778 LEEELVALRES--ERNLRASN-----------------------------------DGRAARLAQ 805
            ||.:...|||.  :.|:.:|:                                   ....|:|.|
Human  1396 LEWDNYDLREDALDDNVSSSSVHDSPLASSPVRKNIFRFDESTTGFNFSFKSALSLSKSPAKLNQ 1460

  Fly   806 LDSQI---EELRQDNTDLQKRSKELVSLVDELRQQNDLLSLENQRQLQFQH-------------- 853
            ..:.:   ||  .|.|..::|..:....|..|....::.|.|...|:.|.|
Human  1461 SGTSVGTDEE--SDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHMAELYRYDKDVGQW 1523

  Fly   854 --------DLMQQH----------RQQVDELDAGHQL---------------------------- 872
                    .::|.:          |.||.:|.|.|::
Human  1524 KERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGER 1588

  Fly   873 ----------------QLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPEQA---KIDYLLMDH 918
                            ...::.::.:.||:..:.::.|.:.|     ::|.::   ||...:::.
Human  1589 KVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRS-----STPRESPCGKIAVAVLEE 1648

  Fly   919 ET--GLDGHAGDVSLAQLAAQRKIST--------------------------ASRRSHDF----- 950
            .|  ..|...|| .:|..|::.::|:                          :|.:|:.|
Human  1649 TTRERTDVIQGD-DVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKSNPFAFGNS 1712

  Fly   951 MPLDELLNTSMNQ--ITSDTVTTISNFGRSVSQQEDEEAEMAARGD---------------FSVQ 998
            .....|...|.|.  .::|:.|:......|.|:.|.::.|::...|               |.::
Human  1713 SATGSLFGFSFNAPLKSNDSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFPME 1777

  Fly   999 SAQL----------------QATKE----RLSIQESRVKHLTALLAENEQDLAKLTQMNDMLKEE 1043
            .:.:                :.|||    :||........|..||.|.|...|.|.:...:||.|
Human  1778 ESSINYTFKTPEKEPPLWHAEFTKEELVQKLSSTTKSADQLNGLLRETEATSAVLMEQIKLLKSE 1842

  Fly  1044 LRRQERSEEREQHMHNSEYLKNVFLKFLTLNNVDERQRLVPVLNTILRLSRNEMEMLNCVAKG 1106
            :||.||::  |:...|.|:||||.|:|:.|....||:.|:||:||:|:||..|...|..||:|
Human  1843 IRRLERNQ--EESAANVEHLKNVLLQFIFLKPGSERESLLPVINTMLQLSPEEKGKLAAVAQG 1903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	PRK03918	<33..559	CDD:235175	126/767 (16%)
		Smc	<357..>920	CDD:440809	136/930 (15%)
		Grip	1057..1103	CDD:197860	21/45 (47%)
RGPD2	XP_054199708.1	Apc1_MidN	91..>206	CDD:466667
		LapB	<189..378	CDD:442196	12/48 (25%)
		TPR repeat	215..245	CDD:276809
		RanBD2_RanBP2-like	1201..1317	CDD:269998	18/119 (15%)
		RanBD3_RanBP2-like	1498..1614	CDD:270204	12/115 (10%)
		Rab_bind	1791..1851	CDD:435531	19/61 (31%)
		GRIP	1854..1897	CDD:460221	20/42 (48%)