Protein Alignment GCC185 and RGPD6

DIOPT Version :10

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: NP_001116835.1
• Gene: RGPD6 / 729540
• HGNCID: 32419
• Length: 1765
• Species: Homo sapiens
• Alignment Length: 1489
• Identity: 275/1489 - (18%)
• Similarity: 510/1489 - (34%)
• Gaps: 486/1489 - (32%)

  Fly    41 AKDELTEENHRLKDALKRAAEKQSSLPAMQEMVQDFTDK--------NLILTEEVNNLKRKTKED 97
            |.|.|::..|.|   |..:..||..|   :|:|:.|.:|        .|..::...:......:|
Human   348 ACDRLSQSGHML---LSLSRGKQDFL---KEVVETFANKIGQSALYDALFSSQSPKDTSFLGSDD 406

  Fly    98 ADRLTQFEIENESLKR-QLGRLSDENDAL------------LANVDRMEKAMQQV--------NA 141
            ..::...|.|.|.|.| .:|.:...|.:|            |..:..:.|.::|:        :.
Human   407 IGKIDVQEPELEDLARYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHRLPHETSR 471

  Fly   142 LGNEQRKNLELLEVDIAKIKEAEAENASLRQQVATMEEESSVLQQKYQNIKELNSEQRKKFNSLK 206
            |.....:::.:|::::..:......:..|:::..:.......|...:...|:|.:|::|.:....
Human   472 LETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPFPVCKQLCTERQKSWWDAV 536

  Fly   207 DRFIDVHRKL--KNLKECKCVLLETQHE------------YAASVSKW----------------Q 241
            ...|  |||.  .||.:.:   |..|||            ..|.:..|                |
Human   537 CTLI--HRKAVPGNLAKLR---LLVQHEINTLRAQEKHGLQPALLVHWAKYLQKTGSGLNSFYGQ 596

  Fly   242 VEIIKASQLLCAKMASLQAENEKLKLNNGKSDNNPQTIDTGIDRKRLLQRVQEMD-RLAKIVKQK 305
            :|.|..|.....|:..|      ||:.  |.::.|:.||.      |.:....:| :.::||:.:
Human   597 LEYIGRSVHYWKKVLPL------LKII--KKNSIPEPIDP------LFKHFHSVDIQASEIVEYE 647

  Fly   306 QKNQRS-------NLNVEYLLKKITALEELAVIIKQQ------HR----IDKEQLISVTKEQENT 353
            :....:       |.|:|   ..:||.|.:..::...      ||    |:.:.|  ..:|||..
Human   648 EDAHITFAMLDAVNGNIE---DAVTAFESIKSVVSYWNLALIFHRKAEDIENDAL--SPEEQEEC 707

  Fly   354 KNHARNLNVSLFQTKLDQMQNLVKVIAKERDNQQ--RKL--------QELEAICIELR------- 401
            :|:       |.:|:    ..|:|:|.....|..  :||        |.|.::..||.
Human   708 RNY-------LTKTR----DYLIKIIDDGDSNLSVVKKLPVPLESVKQMLNSVMQELEDYSEGGP 761

  Fly   402 --------------QHNEDLLTRYHLKEQEHGELLTEMRELNEALKGRGDAISRLQEQHEAEVKR 452
                          :|:....|:|.|...:..:...|...  ...:.|...::.:.:|.||..|.
Human   762 LYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPETPP--RWTEDRNSLLNMICQQVEAIKKE 824

  Fly   453 QRDLEAQLSNSQQAAQEKLQKIKQLQSRVEELEQANADAQSDVLSTSTISRAEELSRLRELDEGY 517
            .::|  :|::|:.|::.:..........|.:..|.:.......|:.:|...:...|:    ...|
Human   825 MQEL--KLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQ----SPAY 883

  Fly   518 EEKYHKLRAIAAKLKKKLQEQTQQLNEMEQSGALKEELEAIKLAQAQLQQDLNAARAENQKLKSK 582
            ..:| .||..|.....|....|:          .|...|...:..:........:...||:.|.:
Human   884 NSQY-LLRPAANVTPTKGSSNTE----------FKSTKEGFSIPVSADGFKFGISEPGNQEKKRE 937

  Fly   583 EKVKHSSVLNLEIEAAEKS-----LSEVSAKLT----AKSSELEAVK------------------ 620
            :.:::.:....:..:..|.     ..:.|:..|    |||:..|..:
Human   938 KPLENDTGFQAQDISGRKKGRGVIFGQTSSTFTFADVAKSTSGEGFQFGKKDLNFKGFSGAGEKL 1002

  Fly   621 -----ESLASKENT-----------------------IVQLRKEIAILEEAKNGEAAHSLELKEQ 657
                 ..:|:|.||                       :||:.:::.::...:..:..:|..:|
Human  1003 FSSRYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEGEKVLYSQGVK-- 1065

  Fly   658 IDRMQVQV--------------KDAVHSKQQAL-----------------TQN------------ 679
            :.|...:|              |:.|:.|.:.|                 |.|
Human  1066 LFRFDAEVRQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWM 1130

  Fly   680 ---KDLEHGVEQAKLEAEQLRLQLSESAQQYESKLNTATQQLLSQTQELEMHLAEQKRLETALRN 741
               .|...|  .||||....:.:..|.|::::.|.....:.||....:....|.:..|....::.
Human  1131 WSASDFSDG--DAKLERLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQR 1193

  Fly   742 AERALEDLRVEYTEYKLKAQSVLRKNQNKGS-----------------NREQELEEELVALRESE 789
            ||.....|: ::..:....|:.:.:.:||||                 |....||.:...|||..
Human  1194 AEEMKSGLK-DFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNAENTGPTLEWDNYDLREDA 1257

  Fly   790 RNLRASNDG-RAARLA--------------------------QLDSQIEELRQDNTDLQKRSKEL 827
            .:...|:.. .|:.||                          .|.....:|.|..|.:....:.:
Human  1258 LDDSVSSSSVHASPLASSPVRKNLFRFDESTTGSNFSFKSALSLSKSPAKLNQSGTSVGTDEESV 1322

  Fly   828 VSLVDELRQQ--------NDLLSL---ENQRQLQFQH----------------------DLMQQH 859
            |:..:|...|        .||:.:   |...|:.|.|                      .::|.:
Human  1323 VTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAEIYRYDKDVGQWKERGIGDIKILQNY 1387

  Fly   860 ----------RQQVDELDAGHQL------------------------------------------ 872
                      |.||.:|.|.|::
Human  1388 DNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDV 1452

  Fly   873 --QLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPEQA---KIDYLLMDHET--GLDGHAGDVS 930
              ...::.::.:.||:..:.::.|.:.|     ::|.::   ||...:::..|  ..|...|| .
Human  1453 ADSFKKIFDEAKTAQEKDSLITPHVSRS-----STPRESPCGKIAVAILEETTRERTDVIQGD-D 1511

  Fly   931 LAQLAAQRKISTASRRSHDFM---PLDELLNTSMNQITS----------DTVTTISNFG------ 976
            :|..|::.::|:.|..:...:   |....::.|:.:|.|          ::..|.|.||
Human  1512 VADAASEVEVSSTSETTTKAVVSPPKFVFVSESVKRIFSSEKSKPFVFGNSSATGSLFGFSFNAP 1576

  Fly   977 --------RSVSQQ------EDEEAEMAARGD---------------FSVQSAQL---------- 1002
                    .||:|.      |.::.|::...|               |..:.:.:
Human  1577 LKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFPTEESSINYTFKTPEKE 1641

  Fly  1003 ------QATKERLSIQESR-----VKHLTALLAENEQDLAKLTQMNDMLKEELRRQERSEEREQH 1056
                  :.|||.| :|:.|     ..||..||.|.|...|.|.:...:||.|:||.||::|||:.
Human  1642 PPLWHAEFTKEEL-VQKLRSTTKSADHLNGLLREIEATNAVLMEQIKLLKSEIRRLERNQEREKS 1705

  Fly  1057 MHNSEYLKNVFLKFLTLNNVDERQRLVPVLNTILRLSRNEMEMLNCVAKGQKVSADGSS 1115
            ..|.||||||.|:|:.|....||:||:||:||:|:||..|...|..||:.::.:|..||
Human  1706 AANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQDEEENASRSS 1764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	PRK03918	<33..559	CDD:235175	116/625 (19%)
		Smc	<357..>920	CDD:440809	124/828 (15%)
		Grip	1057..1103	CDD:197860	23/45 (51%)
RGPD6	NP_001116835.1	TPR 1	26..59
		LapB	<33..222	CDD:442196
		TPR repeat	59..89	CDD:276809
		TPR 2	60..93
		TPR 3	648..681		6/35 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	760..804		5/45 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	924..945		3/20 (15%)
		RanBD2_RanBP2-like	1051..1167	CDD:269998	19/119 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1214..1247		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1306..1330		5/23 (22%)
		RanBD3_RanBP2-like	1348..1464	CDD:270204	11/115 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1580..1621		6/40 (15%)
		Rab_bind	1641..1705	CDD:435531	24/64 (38%)
		GRIP	1706..1749	CDD:460221	22/42 (52%)