DRSC/TRiP Functional Genomics Resources

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Protein Alignment GCC185 and RGPD8

DIOPT Version :9

Sequence 1:NP_001097755.1 Gene:GCC185 / 41459 FlyBaseID:FBgn0037979 Length:1135 Species:Drosophila melanogaster
Sequence 2:NP_001157935.1 Gene:RGPD8 / 727851 HGNCID:9849 Length:1765 Species:Homo sapiens


Alignment Length:1489 Identity:276/1489 - (18%)
Similarity:511/1489 - (34%) Gaps:486/1489 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 AKDELTEENHRLKDALKRAAEKQSSLPAMQEMVQDFTDK--------NLILTEEVNNLKRKTKED 97
            |.|.|::..|.|   |..:..||..|   :|:|:.|.:|        .|..::...:......:|
Human   348 ACDRLSQSGHML---LSLSRGKQDFL---KEVVETFANKIGQSALYDALFSSQSPKDTSFLGSDD 406

  Fly    98 ADRLTQFEIENESLKR-QLGRLSDENDAL------------LANVDRMEKAMQQV--------NA 141
            ..::...|.|.|.|.| .:|.:...|.:|            |..:..:.|.::|:        :.
Human   407 IGKIDVQEPELEDLARYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHRLPHETSR 471

  Fly   142 LGNEQRKNLELLEVDIAKIKEAEAENASLRQQVATMEEESSVLQQKYQNIKELNSEQRKKFNSLK 206
            |.....:::.:|::::..:......:..|:::..:.......|...:...|:|.:|::|.:....
Human   472 LETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPFPVCKQLCTERQKSWWDAV 536

  Fly   207 DRFIDVHRKL--KNLKECKCVLLETQHE------------YAASVSKW----------------Q 241
            ...|  |||.  .||.:.:   |..|||            ..|.:..|                |
Human   537 CTLI--HRKAVPGNLAKLR---LLVQHEINTLRAQEKHGLQPALLVHWAKYLQKTGSGLNSFYGQ 596

  Fly   242 VEIIKASQLLCAKMASLQAENEKLKLNNGKSDNNPQTIDTGIDRKRLLQRVQEMD-RLAKIVKQK 305
            :|.|..|.....|:..|      ||:.  |.::.|:.||.      |.:....:| :.::||:.:
Human   597 LEYIGRSVHYWKKVLPL------LKII--KKNSIPEPIDP------LFKHFHSVDIQASEIVEYE 647

  Fly   306 QKNQRS-------NLNVEYLLKKITALEELAVIIKQQ------HR----IDKEQLISVTKEQENT 353
            :....:       |.|:|   ..:||.|.:..::...      ||    |:.:.|  ..:|||..
Human   648 EDAHITFAILDAVNGNIE---DAVTAFESIKSVVSYWNLALIFHRKAEDIENDAL--SPEEQEEC 707

  Fly   354 KNHARNLNVSLFQTKLDQMQNLVKVIAKERDNQQ--RKL--------QELEAICIELR------- 401
            :|:       |.:|:    ..|:|:|.....|..  :||        |.|.::..||.       
Human   708 RNY-------LTKTR----DYLIKIIDDGDSNLSVVKKLPVPLESVKQMLNSVMQELEDYSEGGP 761

  Fly   402 --------------QHNEDLLTRYHLKEQEHGELLTEMRELNEALKGRGDAISRLQEQHEAEVKR 452
                          :|:....|:|.|...:..:...|...  ...:.|...::.:.:|.||..|.
Human   762 LYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPETPP--RWTEDRNSLLNMICQQVEAIKKE 824

  Fly   453 QRDLEAQLSNSQQAAQEKLQKIKQLQSRVEELEQANADAQSDVLSTSTISRAEELSRLRELDEGY 517
            .::|  :|::|:.|::.:..........|.:..|.:.......|:.:|...:...|:    ...|
Human   825 MQEL--KLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQ----SPAY 883

  Fly   518 EEKYHKLRAIAAKLKKKLQEQTQQLNEMEQSGALKEELEAIKLAQAQLQQDLNAARAENQKLKSK 582
            ..:| .||..|.....|....|:          .|...|...:..:........:...||:.|.:
Human   884 NSQY-LLRPAANVTPTKGSSNTE----------FKSTKEGFSIPVSADGFKFGISEPGNQEKKRE 937

  Fly   583 EKVKHSSVLNL-EIEAAEKS----LSEVSAKLT----AKSSELEAVK------------------ 620
            :.:::.:.|.. :|...:|.    ..:.|:..|    |||:..|..:                  
Human   938 KPLENDTGLQAQDIRGRKKGRGVIFGQTSSTFTFADVAKSTSGEGFQFGKKDLNFKGFSGAGEKL 1002

  Fly   621 -----ESLASKENT-----------------------IVQLRKEIAILEEAKNGEAAHSLELKEQ 657
                 ..:|:|.||                       :||:.:::.::...:..:..:|..:|  
Human  1003 FSSRYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEGEKVLYSQGVK-- 1065

  Fly   658 IDRMQVQV--------------KDAVHSKQQAL-----------------TQN------------ 679
            :.|...:|              |:.|:.|.:.|                 |.|            
Human  1066 LFRFDAEVRQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWM 1130

  Fly   680 ---KDLEHGVEQAKLEAEQLRLQLSESAQQYESKLNTATQQLLSQTQELEMHLAEQKRLETALRN 741
               .|...|  .||||....:.:..|.|::::.|.....:.||....:....|.:..|....::.
Human  1131 WSASDFSDG--DAKLERLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQR 1193

  Fly   742 AERALEDLRVEYTEYKLKAQSVLRKNQNKGS-----------------NREQELEEELVALRESE 789
            ||.....|: ::..:....|:.:.:.:||||                 |....||.:...|||..
Human  1194 AEEMKSGLK-DFKTFLTNDQTKVTEEENKGSGTGVAGASDTTIKPNAENTGPTLEWDNYDLREDA 1257

  Fly   790 RNLRASNDG-RAARLA--------------------------QLDSQIEELRQDNTDLQKRSKEL 827
            .:...|:.. .|:.||                          .|.....:|.|..|.:....:.:
Human  1258 LDDSVSSSSVHASPLASSPVRKNLFRFDESTTGSNFSFKSALSLSKSPAKLNQSGTSVGTDEESV 1322

  Fly   828 VSLVDELRQQ--------NDLLSL---ENQRQLQFQH----------------------DLMQQH 859
            |:..:|...|        .||:.:   |...|:.|.|                      .::|.:
Human  1323 VTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAEIYRYDKDVGQWKERGIGDIKILQNY 1387

  Fly   860 ----------RQQVDELDAGHQL------------------------------------------ 872
                      |.||.:|.|.|::                                          
Human  1388 DNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDV 1452

  Fly   873 --QLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPEQA---KIDYLLMDHET--GLDGHAGDVS 930
              ...::.::.:.||:..:.::.|.:.|     ::|.::   ||...:::..|  ..|...|| .
Human  1453 ADSFKKIFDEAKTAQEKDSLITPHVSRS-----STPRESPCGKIAVAVLEEITRERTDVIQGD-D 1511

  Fly   931 LAQLAAQRKISTASRRSHDFM---PLDELLNTSMNQITS----------DTVTTISNFG------ 976
            :|..|::.::|:.|..:...:   |....::.|:.:|.|          ::..|.|.||      
Human  1512 VADAASEVEVSSTSETTTKAVVSPPKFVFVSESVKRIFSSEKSKPFAFGNSSATGSLFGFSFNAP 1576

  Fly   977 --------RSVSQQ------EDEEAEMAARGD---------------FSVQSAQL---------- 1002
                    .||:|.      |.::.|::...|               |..:.:.:          
Human  1577 LKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFPTEESSINYTFKTPEKE 1641

  Fly  1003 ------QATKERLSIQESR-----VKHLTALLAENEQDLAKLTQMNDMLKEELRRQERSEEREQH 1056
                  :.|||.| :|:.|     ..||..||.|.|...|.|.:...:||.|:||.||::|||:.
Human  1642 PPLWHAEFTKEEL-VQKLRSTTKSADHLNGLLREIEATNAVLMEQIKLLKSEIRRLERNQEREKS 1705

  Fly  1057 MHNSEYLKNVFLKFLTLNNVDERQRLVPVLNTILRLSRNEMEMLNCVAKGQKVSADGSS 1115
            ..|.||||||.|:|:.|....||:||:||:||:|:||..|...|..||:.::.:...||
Human  1706 AANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQDEEENPSRSS 1764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GCC185NP_001097755.1 SMC_prok_B 35..813 CDD:274008 176/1024 (17%)
TMPIT 458..>548 CDD:285135 15/89 (17%)
GRIP 1058..1100 CDD:279767 22/41 (54%)
RGPD8NP_001157935.1 TPR 1 26..59
TPR_11 59..126 CDD:290150
TPR repeat 59..89 CDD:276809
TPR 2 60..93
TPR_1 60..92 CDD:278916
TPR 3 648..681 6/35 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 760..804 5/45 (11%)
YRB1 975..1167 CDD:227499 29/195 (15%)
RanBD2_RanBP2-like 1051..1167 CDD:269998 19/119 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1216..1247 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1306..1330 5/23 (22%)
RanBD3_RanBP2-like 1348..1464 CDD:270204 11/115 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1621 6/40 (15%)
Rab_bind 1641..1705 CDD:293309 24/64 (38%)
GRIP 1707..1749 CDD:279767 22/41 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1746..1765 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 46 1.000 Domainoid score I12111
eggNOG 1 0.900 - - E1_COG5171
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41740
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.900

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