Protein Alignment GCC185 and RGPD3

DIOPT Version :9

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: XP_016860227.1
• Gene: RGPD3 / 653489
• HGNCID: 32416
• Length: 1766
• Species: Homo sapiens
• Alignment Length: 1510
• Identity: 267/1510 - (17%)
• Similarity: 514/1510 - (34%)
• Gaps: 493/1510 - (32%)

  Fly    13 PNPIEALSKDEIISKYKGLLNIAKKAKQAKDELTEENHRL-------KDALKRAAE---KQSSLP 67
            |.|...|.|.|   ..:.||.:     .|.|.|::..|.|       :|.||...|   .:|...
Human   336 PRPKIKLIKGE---AGQNLLEM-----MACDRLSQSGHMLLNLSRGKQDFLKVVVETFANKSGQS 392

  Fly    68 AMQEMV---QDFTDKNLILTEEVNNLKRKTKEDADRLTQFEI-----ENESLKR--QLGRLSDEN 122
            |:.:.:   |...|.:.:.::::.|:..:..|..| |.::::     .|.||:.  .|| |...:
Human   393 ALYDALFSSQSPKDTSFLGSDDIGNIDVQEPELED-LARYDVGAIRAHNGSLQHLTWLG-LQWNS 455

  Fly   123 DALLANVDRMEKAM-----QQVNALGNEQRKNLELLEVDIAKIKEAEAENASLRQQVATMEEESS 182
            ...|..:.:..|.:     |:.:.|.....:::.:|::::..:......:..|:::..:......
Human   456 LPALPGIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQ 520

  Fly   183 VLQQKYQNIKELNSEQRKKF---------------NSLKDRFIDVHRKLKNLKE----------- 221
            .|.......|:|.:|::|.:               ||.|.|.: |..::..|:.
Human   521 PLCLPLPVCKQLCTERQKSWWDAVCTLIHRKAVPGNSAKLRLL-VQHEINTLRAQEKHGLQPALL 584

  Fly   222 ---CKCV--------LLETQHEY-AASVSKWQ-----VEIIKASQLLCAKMASLQAENEKLKLNN 269
               .||:        ....|.|| ..||..|:     ::|||
Human   585 VHWAKCLQKMGSGLNSFYDQREYIGRSVHYWKKVLPLLKIIK----------------------- 626

  Fly   270 GKSDNNPQTIDTGIDRKRLLQRVQEMD-RLAKIVKQKQKNQRS-------NLNVE------YLLK 320
             |.::.|:.||.      |.:....:| :.::||:.::....:       |.|:|      ..:|
Human   627 -KKNSIPEPIDP------LFKHFHSVDIQASEIVEYEEDAHVTFAILDAVNGNIEDAMTAFESIK 684

  Fly   321 KITALEELAVIIKQQHRIDKEQLISVTKEQENTKNHAR---------------NLN-VSLFQTKL 369
            .:.:...||:|..::........:| .:|||..||:.|               ||: |......|
Human   685 SVVSYWNLALIFHRKAEDIANDALS-PEEQEECKNYLRKTRGYLIKILDDSDSNLSVVKKLPVPL 748

  Fly   370 DQMQNLVKVIAKERDNQQR-----KLQELEAICIELRQHNEDLLTRYHLKEQEHGELLTE----- 424
            :.::.::|.:.:|.:|...     |...|.....|:: |:....|:|.|...:..:...:
Human   749 ESVKEMLKSVMQELENYSEGGPLYKNGSLRNADSEIK-HSTPSPTKYSLSPSKSYKYSPKTPPRW 812

  Fly   425 MRELNEALKGRGDAISRLQEQHEAEVKRQRDLEAQLSNSQQAAQEKLQKIKQLQSRVEELEQANA 489
            ..:.|..||.....:..::|:.:         |.:|::|:.|:..:..........|.:..|.:.
Human   813 AEDQNSLLKMIRQEVKAIKEEMQ---------ELKLNSSKSASHHRWPTENYGPDSVPDGYQGSQ 868

  Fly   490 DAQSDVLSTSTISRAEELSRLRELDEGYEEKYHKLRAIAAKLKKKLQEQTQQLNEMEQSGALKEE 554
            ......|:.:|...:...|:    ...|..:| .||..|.....|....|:          .|..
Human   869 TFHGAPLTVATTGPSVYYSQ----SPAYNSQY-LLRPAANVTPTKGSSNTE----------FKST 918

  Fly   555 LEAIKLAQAQLQQDLNAARAENQKLKSKEKVKHSSVLNLEIEAAEKS-----LSEVSAKLT---- 610
            .|...:..:........:...||:.||::.:::.:.|..:..:..|.     ..:.|:..|
Human   919 KEGFSIPVSADGFKFGISEPGNQEKKSEKPLENDTGLQAQDISGRKKGRGVIFGQTSSTFTFADV 983

  Fly   611 AKSSELEAVK-----------------------ESLASKENT----------------------- 629
            |||:..|..:                       ..:|:|.||
Human   984 AKSTSGEGFQFGKKDLNFKGFSGAGEKLFSSQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEP 1048

  Fly   630 IVQLRKEIAILEEAKNGEAAHSLELKEQIDRMQVQV--------------KDAVHSKQQALTQNK 680
            :||:.:::.::...:..:..:|..:|  :.|...:|              |:.|:.|.:.|.|.:
Human  1049 VVQMPEKVELVTGEEGEKVLYSQGVK--LFRFDAEVSQWKERGLGNLKILKNEVNGKVRMLMQRE 1111

  Fly   681 DL-----EHGVE-------------------------QAKLEAEQLRLQLSESAQQYESKLNTAT 715
            .:     .|.:.                         .||||....:.:..|.|::::.|.....
Human  1112 QVLKVCANHWITTTMNLKPLSGSDRAWMWSASDFSDGDAKLERLAAKFKTPELAEEFKQKFEECQ 1176

  Fly   716 QQLLSQTQELEMHLAEQKRLETALRNAERALEDLRVEYTEYKLKAQSVLRKNQNKGSN------- 773
            :.||....:....|.:..|....::.||.....|: ::..:....|:.:.:.:||||.
Human  1177 RLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLK-DFKTFLTNDQTKVAEEENKGSGTGAAGAS 1240

  Fly   774 ----------------------REQELEEEL---------VALRESERNL-------RASN---- 796
                                  ||..|::.:         :|.....:||       ..||
Human  1241 DTTIKPNAENTGPTLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFHFDESTTGSNFSFK 1305

  Fly   797 -----DGRAARLAQLDSQI---EELRQDNTDLQKRSKELVSLVDELRQQNDLLSLENQRQLQFQH 853
                 ....|:|.|..:.:   ||  .|.|..::|..:....|..|....::.|.|...|:.|.|
Human  1306 SALSLSKSPAKLNQSGTSVGTDEE--SDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSH 1368

  Fly   854 ----------------------DLMQQH----------RQQVDELDAGHQL-------------- 872
                                  .::|.:          |.||.:|.|.|::
Human  1369 RAEFYRYDKDVGQWKERGIGDIKILQNYDNKHVRILMRRDQVLKLCANHRITPDMSLQNMKGTER 1433

  Fly   873 ------------------------------QLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPE 907
                                          ...::.::.:.||:..:.::.|.:.|     ::|.
Human  1434 VWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRS-----STPR 1493

  Fly   908 QA---KIDYLLMDHET--GLDGHAGDVSLAQLAAQRKIST------------------------- 942
            ::   ||...:::..|  ..|...|| .:|..|::.::|:
Human  1494 ESPCGKIAVAVLEETTRERTDVIQGD-DVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRI 1557

  Fly   943 -ASRRSHDF-----MPLDELLNTSMN---QITSDTVTTISNFGRSVSQQEDEEAEMAARGD---- 994
             :|.:|..|     .....|...|.|   :..:...::::..| |.|:.|.::.|::...|
Human  1558 FSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSG-SESKVEPKKCELSKNSDIEQS 1621

  Fly   995 -----------FSVQSAQL----------------QATKE----RLSIQESRVKHLTALLAENEQ 1028
                       |..:.:.:                :.|||    :||.......||..||.|.|.
Human  1622 SDSKVKNLSASFPTEESSINYTFKTPEKEPPLWYAEFTKEELVQKLSSTTKSADHLNGLLREIEA 1686

  Fly  1029 DLAKLTQMNDMLKEELRRQERSEEREQHMHNSEYLKNVFLKFLTLNNVDERQRLVPVLNTILRLS 1093
            ..|.|.:...:||.|:||.||::|:|....|.|:||||.|:|:.|....||:||:||:||:|:||
Human  1687 TNAVLMEQIKLLKSEIRRLERNQEQEVSAANVEHLKNVLLQFIFLKPGSERERLLPVINTMLQLS 1751

  Fly  1094 RNEMEMLNCVAKGQK 1108
            ..|...|..||:|::
Human  1752 LEEKGKLAAVAQGEE 1766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	168/1041 (16%)
		TMPIT	458..>548	CDD:285135	15/89 (17%)
		GRIP	1058..1100	CDD:279767	21/41 (51%)
RGPD3	XP_016860227.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12111
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41740
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.900