DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GCC185 and RANBP1

DIOPT Version :9

Sequence 1:	NP_001097755.1	Gene:	GCC185 / 41459	FlyBaseID:	FBgn0037979	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	NP_001265568.1	Gene:	RANBP1 / 5902	HGNCID:	9847	Length:	278	Species:	Homo sapiens

Alignment Length:	211	Identity:	48/211 - (22%)
Similarity:	93/211 - (44%)	Gaps:	44/211 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 EELEQANADAQSDVLSTSTISRAEELSRLRELDEGYEEKYHKLRAIAAKLKKKLQEQTQQLNEME 546
            |..:::|.|.|.:.:    :|..|:  .::.|:|. ||:..|:|   |||.:...|  ..|.|.:
Human    93 ENTDESNHDPQFEPI----VSLPEQ--EIKTLEED-EEELFKMR---AKLFRFASE--NDLPEWK 145

  Fly   547 QSGA-----LK-EELEAIKLAQAQLQQDLNAARAENQKLKSKEKVKHSS------VLNLEIEAAE 599
            :.|.     || :|..||:|.   :::|.......|..:....::|.::      |.|...:.|:
Human   146 ERGTGDVKLLKHKEKGAIRLL---MRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFAD 207

  Fly   600 KSLSEVSAKLTAKSSELEAVK----ESLASKENTIVQLRKEIAILE-EAKNGEAAHSLELKEQID 659
            :          ....||.|::    |:....:....:.||||...| :|.:|:..|:.::.|:::
Human   208 E----------CPKPELLAIRFLNAENAQKFKTKFEECRKEIEEREKKAGSGKNDHAEKVAEKLE 262

  Fly   660 RMQV--QVKDAVHSKQ 673
            .:.|  :.|:....||
Human   263 ALSVKEETKEDAEEKQ 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	48/211 (23%)
		TMPIT	458..>548	CDD:285135	18/65 (28%)
		GRIP	1058..1100	CDD:279767
RANBP1	NP_001265568.1	RanBD_RanBP1	101..237	CDD:270000	33/160 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900