Protein Alignment GCC185 and numa1

DIOPT Version :9

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: NP_001316910.1
• Gene: numa1 / 572344
• ZFINID: ZDB-GENE-110517-1
• Length: 2450
• Species: Danio rerio
• Alignment Length: 1459
• Identity: 308/1459 - (21%)
• Similarity: 564/1459 - (38%)
• Gaps: 458/1459 - (31%)

  Fly    36 KKAKQAKDELTEENHRLKDALKRAAEKQSSLPAM------------------------------- 69
            :|.||...:||.:..:|::::....:|::.:.|:
Zfish   410 EKLKQELADLTLQLAQLQESISHLEKKKAEVEALLAEERCSFEKETARLQLVVFDLEKSINSIRL 474

  Fly    70 -QEMVQDF--TDKNLILTEEVNNLKRKTKEDADRLTQFEIE---NESLKRQLGRLSDENDALLAN 128
             :|.:|:.  |.|.: |:.:::.|:|    |..||.|.|::   ...:...|.:..:|.:..:|:
Zfish   475 ERETLQEALKTQKEM-LSAQISALER----DVSRLQQVEVQLTAEIKISADLRQQREELEGKVAS 534

  Fly   129 VDRM-------------EKAMQQ--VNALGNE---QRKNLELLEVDIAKIKEAEAENASLRQQVA 175
            :|||             |:|.||  :|:|.::   .|..::..|..:.:.::..|||.||:.:..
Zfish   535 LDRMVHSLHAEIQGLEVERASQQDAINSLISDLQIARATVQEYEKKLEEHQKVVAENNSLKNEAC 599

  Fly   176 TMEEE------------SSVLQQKYQNIKELN--SEQRKKFN-------------SLKDRFI--- 210
            ||::|            :.|.:.:::..:|.|  ||...|..             ||||..|
Zfish   600 TMQQELNNHLKAIGDLQAEVNELRFEKTEEENKVSEALVKIESLQTEILHLCEKISLKDEEIRNL 664

  Fly   211 -----DVHRKLKNLK----ECKCVLLETQHEYAASVSKWQVEIIKASQ----------LLCAKMA 256
                 .|..:||.:|    |...::...:.|:..:|.|.|.|:..|:.          :|.|::.
Zfish   665 TKEYESVDNELKLVKEQNVEINAMIKSNRKEHEETVEKLQQELHCAASAASEKQEQMLVLSAEVT 729

  Fly   257 SLQ------AENEK---------------LKLNNGKSDNNPQTIDTGIDRKR-----LLQRVQEM 295
            ||:      :|||.               ||.|.....|......|...:|.     |.|.:...
Zfish   730 SLKEQICRYSENEAQKQQELSILEAQHNVLKENLTSLQNQLAEATTSASQKESEFILLQQELSHQ 794

  Fly   296 DRLAKIVKQKQKNQRSNLN--VEYLLKKI-----TALEELAVIIKQQHRIDKEQLISVTKEQENT 353
            :.|.:..::.:|.:|..|.  |..|..||     .|.|..|.:...|:.: |:||....:.:.:.
Zfish   795 ETLREQTQELEKIKREELEGIVSELQAKIIEVSSIASEREACVSSLQYEM-KDQLSKAKQCEADL 858

  Fly   354 KN-------------------------HARNLNVSLFQTKLDQMQNLVKVIAKERDNQQ------ 387
            :|                         |..:||.||.|.:|...|...::||.::..||
Zfish   859 RNEMKEKVGNLQELLDAANHGIAEKEHHLESLNQSLKQMELLYCQKEEEIIASQQAKQQLENNIA 923

  Fly   388 ---RKLQELEAICIELRQHNEDLLTR-------YHLKEQEHGELLTEMRELNEALKGRGDAISRL 442
               ::|.|::.....||...:.|.||       .|..:|:..:|.|:...|.|.|....|.:.:.
Zfish   924 EQKQQLDEIQQNREILRNERDHLSTRVSSLQEEIHRSQQDFSDLQTDHNVLKEKLVNLQDQVEQA 988

  Fly   443 Q---EQHEAEVKRQRDLEAQLSNSQQAAQEKLQ-----------KIKQLQSRVEELEQANADAQS 493
            .   .|.|:|:..   |:.:||:.:...::.|:           |:|:||.|:.|:....:..::
Zfish   989 MITASQKESELLL---LQQELSHQETLREKALELEAIKREEFEKKVKELQDRILEVSTLASQREA 1050

  Fly   494 DVLSTSTISRAEELSRLR------------------ELD---EGYEEKYHKLRAIAAKL------ 531
            .|:|.....|.::||..:                  |||   ....:|.|:|.::..||
Zfish  1051 QVISLENEMRDQQLSANQSKDNLCREWQEKLGILKGELDVVSRDAADKDHQLESLDQKLKEMEMV 1115

  Fly   532 --------------KKKLQEQTQQLNEMEQS---------------GALKEELEAIKLAQAQLQQ 567
                          |:.|:::..:|.|.:|.               .:||||:.:.:..|.|.||
Zfish  1116 VLQKEKDVMETHQAKEDLEKRIAELEECKQKLEIMRNERDHLSTEVASLKEEIHSYQDTQMQKQQ 1180

  Fly   568 DLNAARAENQKLKSKEKVKHSSVLNLEIEAAEKSLSEVSAKLTAKSSELEAVKESLASKENTIVQ 632
            .::....||..||.            .:.|.||.|:|.....:.|:|||:.             :
Zfish  1181 TISVLEVENNALKE------------NMAALEKQLAEEITTASQKNSELQN-------------K 1220

  Fly   633 LRKEIAILEEAKNGEAAHSLELKEQIDRMQVQV---------KDAV-HSKQQALTQNKDLEHGVE 687
            |.::.::.|:|:..|.....|.:.::..:|.:|         |:|| :|.|:.||       |..
Zfish  1221 LHQQESLHEKAQELEIGRHEEFERRVRELQAKVQEVSTLASEKEAVAYSLQEELT-------GHL 1278

  Fly   688 QAKLEAEQLRLQLSESAQQYESKLNTAT----------QQLLSQTQELEMHLAEQKRLETALRNA 742
            :||:..:.||..|.|..:..:.::.||:          |.|..:.:::|| |.:||  |.|:...
Zfish  1279 KAKVSEDDLRRVLEEKVETLQREIETASCDATSKDGLLQTLDQKLRQMEM-LCQQK--EDAVFEI 1340

  Fly   743 ERALEDLRVEYTEYKLKAQ---------SVLRKNQNKGSNREQELEEELVALRESERNLRASNDG 798
            :.:.|||:.|..|...|.|         .:::|.::..||....|:|::     ::::|||....
Zfish  1341 QNSKEDLQKEMNELVSKNQELEGCLQHLEMVKKEKDLLSNEVTSLKEQI-----NDQSLRAKQSE 1400

  Fly   799 R------AARLAQLDSQIEELRQDNTDLQKRSKEL---VSLVDELRQQ--NDLLSLENQRQ-LQF 851
            .      ..::..|..|:|....|.:|.:|..:.|   ||.:|.|.||  |.:|.::|.:: ||.
Zfish  1401 ADLCIVFEEKIETLQGQLESSSCDVSDKEKHLQTLHQKVSQMDLLCQQKENAVLEMQNAKEDLQK 1465

  Fly   852 QHDLMQQHRQQVD-----------ELDAGHQLQLTQVQEQLEEAQKMQANVSQ------------ 893
            :.|.:...:||::           |.|. ...::|.:::||.: |.::|..|:
Zfish  1466 KIDELVSEKQQLEGCLQNLEMVKSERDL-LSTEVTSLKDQLND-QDLKAKQSEDDLRKVLEEKIK 1528

  Fly   894 --HTTASAASVDTSPEQ----------AKIDYL----------LMDHETGLDGHAGDVSL--AQL 934
              ......||.|.|.:.          .::|.|          |:..:..|:...|::::  .||
Zfish  1529 NLQGQLETASRDVSEKDQLLQTLDQKVTQMDQLCKQKEKYALDLLQVKENLEKRIGEITVEKQQL 1593

  Fly   935 -AAQRKISTASRRSHDFMPLDELLNTSMNQITSDTVTTISNFGRSVSQQEDEEAEMAARGDFSVQ 998
             ..|:.:.|.|:..      |.||    |::|.          ..|..|..:|.|:..:.:.||.
Zfish  1594 EGCQQNLETVSKDK------DNLL----NELTF----------LKVEIQSYQEKEVQMKHELSVL 1638

  Fly   999 SAQLQATKERLSIQESRVKHLTALLAENEQDLAKLTQMNDMLKEELRRQER-------------- 1049
            ..:....:|.|...:.:|..|||..::.|.:|.......:.|:|:.::.|:
Zfish  1639 ENEHNILQENLDTLQKQVVELTASASQKESELQNEVCKQEKLQEKAQKLEKDAGDLQAKILEIST 1703

  Fly  1050 -SEEREQHMH------NSEYLK---------NVF----------LKFLTLNNVDERQRLVPVLNT 1088
             :.|||..:.      ||::||         .||          |:...| :|.::.:|:..||.
Zfish  1704 LASEREAQISSLKDEINSQHLKAKQSEDDLLRVFEEKIENLQGQLEIARL-DVSDKDQLLQTLNQ 1767

  Fly  1089 ILRLSRNEMEML-----NCVAKGQKVSAD 1112
            .|:    :||.|     .||.:..:...|
Zfish  1768 KLK----QMEELCKQKETCVLEMHQTKED 1792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	224/1059 (21%)
		TMPIT	458..>548	CDD:285135	26/141 (18%)
		GRIP	1058..1100	CDD:279767	15/66 (23%)
numa1	NP_001316910.1	SCP-1	176..919	CDD:114219	107/514 (21%)
		Myosin_tail_1	840..1772	CDD:279860	212/1002 (21%)
		DUF4515	1707..1913	CDD:291649	22/91 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930