Protein Alignment GCC185 and NUMA1

DIOPT Version :10

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: XP_011543356.1
• Gene: NUMA1 / 4926
• HGNCID: 8059
• Length: 2133
• Species: Homo sapiens
• Alignment Length: 1265
• Identity: 292/1265 - (23%)
• Similarity: 528/1265 - (41%)
• Gaps: 298/1265 - (23%)

  Fly     2 EAASPRETQKNPNPIEAL-SKDEIISKYKGLLNIAKKAKQAKD-------------ELTEENHRL 52
            :||||.|    |..:|.| .|:|.::     :.:.:..||.:|             :|:|||..|
Human   268 QAASPLE----PKELEELRDKNESLT-----MRLHETLKQCQDLKTEKSQMDRKINQLSEENGDL 323

  Fly    53 KDALKRAAEKQSSLPAMQEMVQDFTDKNLILTEEVNNLKRKTKEDADRLTQFEIENESLKRQLGR 117
            ...|:..|   |.|..:|:.:.:.|:::          .:.|:|..::..|.|.|..:..:....
Human   324 SFKLREFA---SHLQQLQDALNELTEEH----------SKATQEWLEKQAQLEKELSAALQDKKC 375

  Fly   118 LSDENDALLANVDRMEKAMQQVNALGNEQRKNLELLEVDIAKIKEAEAENASLRQQVATMEEESS 182
            |.::|:.|...:.::|:.:.|:.  .|..::..|:|. |:.:::       :|:|:.||:...::
Human   376 LEEKNEILQGKLSQLEEHLSQLQ--DNPPQEKGEVLG-DVLQLE-------TLKQEAATLAANNT 430

  Fly   183 VLQQKYQNIKELNSEQRKKFNSLKDRFIDVHRKLKNLKECKCVLLETQHEYAASVSKWQVEIIKA 247
            .||.:.:.::....:|..|..:.:..|.:..::|.:|      :.:.|.. .:::|:.:.|:.:|
Human   431 QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSL------ITDLQSS-ISNLSQAKEELEQA 488

  Fly   248 SQL----LCAKMASLQAENEKLKLNNGKSDNNPQTIDTGIDRKRLLQRVQEMDRLAKIVKQKQKN 308
            ||.    |.|::|||.:|...|.....:.|.         :...|.|:.:|  :.|::.:..|:.
Human   489 SQAHGARLTAQVASLTSELTTLNATIQQQDQ---------ELAGLKQQAKE--KQAQLAQTLQQQ 542

  Fly   309 QRSNLNVEYLLKKITALEELAVIIKQQHRIDKEQLISVTKEQENTK-NHARNLNVSLFQTK---- 368
            ::::..:.:      .:|:|:..:||:    ::||..|.::||.|: :||:.|..:..:.:
Human   543 EQASQGLRH------QVEQLSSSLKQK----EQQLKEVAEKQEATRQDHAQQLATAAEEREASLR 597

  Fly   369 -----LDQMQNLVKVIAKERDNQQRKLQELEAICIELRQHNEDLLTRYHLKEQEHGELLTEMREL 428
                 |.|::.|.|..|.:.:..|::||    :..|.|...:..:|:   .::|..||..::.||
Human   598 ERDAALKQLEALEKEKAAKLEILQQQLQ----VANEARDSAQTSVTQ---AQREKAELSRKVEEL 655

  Fly   429 NEALKGRGDAISRLQEQHEAEVKRQRDLEAQLSNSQQAA-------------QEKLQKIKQ---- 476
            ...::      :..||||||:. :..:||.||.:.||.|             ||:||.:|:
Human   656 QACVE------TARQEQHEAQA-QVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKV 713

  Fly   477 LQSRVEELEQANADAQSD------VLSTSTISRAEELSRLR-ELDE------GYEEKYHKL---- 524
            .:..:||.::..|||..:      .|...|.|..|:..|.| ||:|      |.|.:..:|
Human   714 TKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAH 778

  Fly   525 RAIAAKLKKKLQE----------QTQQLNEMEQSGALKEELEAIKLAQAQ-----------LQQD 568
            :|....|:::|.|          :.:||  :::..|.:|..|..:..:||           |:::
Human   779 QAETEVLRRELAEAMAAQHTAESECEQL--VKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEE 841

  Fly   569 LNAARAENQKLKSKEKV----KHSSVLNLEIEAAEKSLSEVSAKLT-----AKSSELEAVK--ES 622
            ...||.|.|  ::||||    .||   .|:|...:..|:|:.|.|.     .:..|:.|.|  :.
Human   842 CEKARQELQ--EAKEKVAGIESHS---ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADD 901

  Fly   623 LASKENTIVQLRKEIAILEE--AKNGE----AAHSLELKE-------QIDRMQVQVKDAVHSKQQ 674
            |::.:..:....||:|.||.  .|.||    |:..| :||       |.:.::.|......|.|.
Human   902 LSTLQEKMAATSKEVARLETLVRKAGEQQETASREL-VKEPARAGDRQPEWLEEQQGRQFCSTQA 965

  Fly   675 ALTQNKDLEHGVEQAKLEAEQLRLQLSESAQQYESKLNTATQQLLSQTQE-------LEMHLAEQ 732
            ||   :.:|...||...|.|:||..|.||..|.:.:.....:::...|||       |.:..|.:
Human   966 AL---QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027

  Fly   733 KRLETALRNAERALEDLRVEYTEYKLKAQSVLRKNQNKGSNREQELEEELVALRESERNLRASND 797
            ..||..|:|   ||.:.|||:...:......|.:.:.|        ::||..||..|
Human  1028 AELEMRLQN---ALNEQRVEFATLQEALAHALTEKEGK--------DQELAKLRGLE-------- 1073

  Fly   798 GRAARLAQLDSQIEELRQDNTDLQKRSKELVS-----------------LVDELRQQNDLLSLEN 845
              ||::.:|:...:.::|....|.|:.||..|                 .::.||.:...|..:.
Human  1074 --AAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQC 1136

  Fly   846 QRQLQFQHDLMQQHRQQVDELDAGHQLQLTQVQEQLEE-AQKMQANVSQHTTASAASVDTSPEQA 909
            |:| |.|.|.:::..:......|.....|..:|.|||| ||::  ..||...|||     ..|.|
Human  1137 QKQ-QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQEL--GHSQSALASA-----QRELA 1193

  Fly   910 KIDYLLMDHETGLDGHAGDVSLAQLAAQRKISTASRRSHDFMPLDELLNTSMNQITSDTVTTISN 974
            .....:.||....|.....|:..:..|:||                      |.:.|.....:|.
Human  1194 AFRTKVQDHSKAEDEWKAQVARGRQEAERK----------------------NSLISSLEEEVSI 1236

  Fly   975 FGRSVSQQEDEEAEMAARGDFSVQSAQLQATKERLSI-------QESRVKHLTALLAENEQDLAK 1032
            ..|.|.::|.|..|:  :.....:|.:.|..:|||.:       ..:|....::.|.|..|.|.:
Human  1237 LNRQVLEKEGESKEL--KRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLRE 1299

  Fly  1033 LTQMNDMLKEELRRQ-----ERSEEREQHM---HNSEYLKNVFLKFLTLNNVDER---QRLVPVL 1086
            ..:...:..|.||::     ||:||..|.:   ....:.|...|..|.|.:...:   ..|:|..
Human  1300 EAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAK 1364

  Fly  1087 NTILRLS----------RNEMEMLNCVAKG 1106
            :...:|.          |.|:|.....|.|
Human  1365 HLCQQLQAEQAAAEKRHREELEQSKQAAGG 1394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	PRK03918	<33..559	CDD:235175	131/596 (22%)
		Smc	<357..>920	CDD:440809	170/675 (25%)
		Grip	1057..1103	CDD:197860	10/61 (16%)
NUMA1	XP_011543356.1	HkD_NuMA	6..152	CDD:411795
		SMC_prok_B	<215..911	CDD:274008	164/723 (23%)
		EnvC	832..>1042	CDD:443969	61/221 (28%)
		Smc	<1023..>1656	CDD:440809	95/425 (22%)
		PHA03307	1764..>2034	CDD:223039
		NuMA_LGNBD	1888..1946	CDD:412093