Protein Alignment GCC185 and gcc1

DIOPT Version :10

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: NP_001003599.1
• Gene: gcc1 / 445205
• ZFINID: ZDB-GENE-040801-118
• Length: 802
• Species: Danio rerio
• Alignment Length: 1061
• Identity: 228/1061 - (21%)
• Similarity: 401/1061 - (37%)
• Gaps: 346/1061 - (32%)

  Fly   143 GNEQRKNLELLEV-------------DIAK-----IKEAEAENASLRQQVATMEEESSVLQQKYQ 189
            |..:::.||.:||             |:.:     :||.||..|||:  |.|:.:|..:     .
Zfish    11 GPSKKELLETIEVQKKQLVKYQTRFKDVVRAYQSLLKEKEALEASLK--VLTISQEVDL-----S 68

  Fly   190 NIKELNSEQRKKFNSLKDRFIDVHRKLKNLKECKCVL-----LET--QHEYAASVSKWQVEIIKA 247
            .:..|:..:.....:|.          .:|.:.:|.|     |:|  ..|.|.||:.   ...|.
Zfish    69 RVDNLSFGEASGSRALP----------SDLGDDRCSLHSEDSLDTAASAETATSVTS---NSTKG 120

  Fly   248 SQL----LCA-------------KMASLQAENEKLKL---NNGKSDNNPQTIDTGIDRKRLLQRV 292
            .|:    .||             ...|.:|...:..:   ::|.|:..||..||  || |::|
Zfish   121 DQIEDDQSCAVDGATAGAVVHTSPQQSEEASGSESGVSTSSSGCSEPTPQVADT--DR-RVIQ-- 180

  Fly   293 QEMDRLAKIVKQKQKNQRSNLNVEYLLKKITALEELAVIIKQQHRIDKEQLISVTKEQENTKNHA 357
                         .|.|.|.|.           ..||.:.:::.|::    .|...::...|...
Zfish   181 -------------LKTQLSTLT-----------SSLATVTQEKSRME----ASFQADKRKMKQEL 217

  Fly   358 RNLNVSLFQTKLDQMQNLVKVIAKERDNQQRKLQELEAICIELRQHNEDLLTRYHLKEQEHGELL 422
            ..|     |.:|::          ::...|.:||.|:.   :..:....::|:.|.:|||.|:..
Zfish   218 EEL-----QARLEE----------DKKQHQAELQNLQE---QFAESKARVITQQHEREQEQGDHA 264

  Fly   423 TEMRELNEALKGRGDAISRLQEQ----HEAEVKRQRDLEAQLSNSQQAAQEKLQKIKQLQSRVEE 483
            ..:|||.:.          |||:    .:||:|.: |..|.|:.:.|||...|....||:..::|
Zfish   265 LMLRELQKL----------LQEERGLRQDAELKLE-DARATLAEAMQAADRGLDYESQLKEIIQE 318

  Fly   484 LEQANADAQSDVLSTSTISRAEELSRLRELDEGYEEKYHKLRAIAAKLKKKLQEQTQQLNEMEQS 548
            .|:....     |..:.:..::...|:.||.:.           .|.||....:|.||
Zfish   319 REELKKS-----LKAAAVENSKPDPRVEELQQE-----------NADLKAHFNQQLQQ------- 360

  Fly   549 GALKEELEAIKLAQAQLQQDLNAARAENQKLKSKEKVKHSSVLNLEIEAAEKSLSEVSAKLTAKS 613
                   |..|:|||.                                           :|..:.
Zfish   361 -------EIRKVAQAD-------------------------------------------ELLREQ 375

  Fly   614 SELEAVKESLASKENTIVQLRKEIAILEEAKNGEAAHSLELKEQIDRMQVQVKD----AVHSKQQ 674
            :::|.::  :||.|..:.:|.:.:...|:|:..:..::..|:|:|.::..:.|.    ||:....
Zfish   376 AKMEEIR--VASLEERVSELSELLGACEKARQKDQQNTQRLRERILQLDTENKTLAMAAVNRTTS 438

  Fly   675 ALTQNKDLEHGVEQAKLEAEQLRLQLSESAQQYESKLNTATQQLLSQTQELEM----------HL 729
            :.....|:...|:..|.:.|:::..|..:||:             ||.|.|::          |.
Zfish   439 SDLNMDDMNLNVDALKDKLEKVKKLLLLAAQR-------------SQDQSLDIEKLLEGGEKDHE 490

  Fly   730 AEQKRLETALRNAERALEDLRVEYTEYKLKAQSVLRKNQNKGSNREQELEE---ELVALRESERN 791
            ..:....:|| :.::.|..::.|:..||::||.||:....|..|:.:||||   :|..|:|...|
Zfish   491 VSESEKASAL-HYQQELRQIKEEFERYKMRAQGVLKNKNTKDGNQAKELEEARDQLAELKEKYIN 554

  Fly   792 LRASNDGRAARLAQLDSQIEELRQDNTDLQKRSKELVSLVDELRQQNDLLSLENQRQLQFQHDLM 856
            ||..:|         :::::..|    ||::|.:.|.:                         |.
Zfish   555 LRIQSD---------EAEVKHKR----DLEERQQGLAA-------------------------LQ 581

  Fly   857 QQHRQQVDELDAGHQLQLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPEQAKIDYLLMDHETG 921
            |.|:|:|::|:|.|:....:::|:|.:.:       ..|.|..|..|...|:.:...::     |
Zfish   582 QTHKQEVEKLEAQHRENFMRLEEELHKQR-------DRTMALLAEKDLELERLRASAVM-----G 634

  Fly   922 LDGHAGDVSLAQLAAQRKI--STASRRSHDFMPLDELLNTSMNQITSDTVTTISNFGRSVSQQED 984
            ...|           ||.|  |:.:....|   |||:   ...|..||.:      .:::.....
Zfish   635 FGSH-----------QRHIINSSTALEGGD---LDEV---DPEQEESDII------AQALKLAGP 676

  Fly   985 EE------AEMAARGDFSVQSAQLQATKERLSIQESRVKHLTA-LLAENEQDLAKLTQMNDMLKE 1042
            .|      ||..||.:  |:.|.|:..|.||   |..:..|.. |:|..|:...:|.::...|.:
Zfish   677 NEPTLLLYAEQLARKE--VEVAALRKQKHRL---EEDLHQLQGKLIANGERHEEELVELRGQLDK 736

  Fly  1043 ELRRQERSEEREQHMHNSEYLKNVFLKFLTLNNVDERQRLVPVLNTILRLSRNEMEMLNCVAKGQ 1107
            .:|.:.|...      |.||||||..|||||.:...||:.:..:.|||..|..|.::   |.|.|
Zfish   737 RIRDKGRDGA------NLEYLKNVIYKFLTLQDTRGRQQTLTAILTILHFSPQEKQV---VLKQQ 792

  Fly  1108 KVSADGSSRSWTGFLTAWSGG 1128
            :       .||      |:.|
Zfish   793 Q-------HSW------WTAG 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	PRK03918	<33..559	CDD:235175	96/464 (21%)
		Smc	<357..>920	CDD:440809	117/583 (20%)
		Grip	1057..1103	CDD:197860	19/45 (42%)
gcc1	NP_001003599.1	Smc	<215..>752	CDD:440809	153/738 (21%)
		GRIP	745..788	CDD:460221	19/51 (37%)