Protein Alignment GCC185 and RGPD1

DIOPT Version :9

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: XP_016859592.1
• Gene: RGPD1 / 400966
• HGNCID: 32414
• Length: 1805
• Species: Homo sapiens
• Alignment Length: 1622
• Identity: 275/1622 - (16%)
• Similarity: 515/1622 - (31%)
• Gaps: 608/1622 - (37%)

  Fly    44 ELTEENHRLKDALKRAAEKQ-----------------------SSLPAMQEMVQDFTDKNLILTE 85
            ||...|.|||||:.|..|.:                       .||..::....|:...|..|..
Human   217 ELYRSNKRLKDAVARCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLL 281

  Fly    86 EVNNL------KRKTKEDADRLTQFEIENESLKRQLGRLSDENDALLANVDRME----------- 133
            ...||      .|..:|..:.|..|:...:|.|..||    .||.|.|....|:
Human   282 AYANLMLLTLSTRDVQESRELLESFDSALQSAKSSLG----GNDELSATFLEMKGHFYMHAGSLL 342

  Fly   134 ------------KAMQQVNAL-----------------GNEQRKNLELLEVDIAK------IKEA 163
                        :|:.::.||                 |...:..||::..|...      :..:
Human   343 LKMGQHGNNVQWQALSELAALCYVIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLNLS 407

  Fly   164 EAENASLRQQVATMEEES--SVLQQKYQNIKELNSEQRKKFNSLKD-RFIDVHR-KLKNLKECKC 224
            ..:...|::.|.|...:|  |||   |..:....|.:...|....| ..|||.. :|::|.....
Human   408 RGKQDFLKEVVETFANKSGQSVL---YNALFSSQSSKDTSFLGSDDIGNIDVQEPELEDLARYDV 469

  Fly   225 VLLET-----QH-----------EYAASVSKWQVEII------------KASQLLC--------- 252
            ..::.     ||           .....:.||..::.            .|.:.:|
Human   470 GAIQAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLL 534

  Fly   253 --AKMASLQAENEKLKLNNGKSDNNPQTIDTGIDRKRLLQRVQE-MDRLAKIVKQKQ---KNQRS 311
              ...:.||.   |.|.|:..|...|..:...:.::...:|.:. .|.:..::.:|.   .:...
Human   535 GVVYTSHLQL---KEKCNSHHSSYQPLCLPLPVCKRLCTERQKSWWDAVCTLIHRKAVPGNSAEL 596

  Fly   312 NLNVEYLLKKITALEELAVIIKQQHRIDKEQLISVTKEQENTKNHARNLNVSLFQTKL------- 369
            .|.|::.:..:.|        :::|.:....|:...|   ..:...|.||.|..|.:.
Human   597 RLVVQHEINTLRA--------QEKHGLQPALLVHWAK---CLQKMGRGLNSSYDQQEYIGRSVHY 650

  Fly   370 -DQMQNLVKVIAKER-----DNQQRKLQELEAICIELRQHNEDLLTRYHLKEQEHGELLTEMREL 428
             .::..|:|:|.|..     |...:....::....|:.::.||....:.:.:..||.:...:...
Human   651 WKKVLPLLKIIKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVHGNIEDAVTAF 715

  Fly   429 NEALKG------------------RGDAISRLQEQHEAE--VKRQRDLEAQL---SNSQQAAQEK 470
             |::|.                  ..||:.. :||.|.:  :::.||...::   |:|..:..:|
Human   716 -ESIKSVVSYWNLALIFHRKAEDIENDAVFP-EEQEECKNYLRKTRDYLIKIIDDSDSNLSVVKK 778

  Fly   471 ----LQKIKQ-LQSRVEELEQ-------------ANADAQ------------------------- 492
                |:.:|: |:|.::|||.             .|||::
Human   779 LPVPLESVKEMLKSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPKT 843

  Fly   493 ----------------SDVLSTSTISRAEELSRLR---------ELDEGYE--EKYH-------- 522
                            .:|.:.:.::.::..||.|         .:.:||:  :.:|
Human   844 PPRWAEDQNSLRKMICQEVKAITKLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHGAPLTVAT 908

  Fly   523 -----------------KLRAIAAKLKKKLQEQTQQLNEMEQSGALKEELEAIKLAQAQLQQDLN 570
                             .||..|.....|....|:          .|...|...:|.:.......
Human   909 TGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTE----------FKSTKEGFSIAVSADGFKFG 963

  Fly   571 AARAENQKLKSKEKVKHSSVLNLEIEAAEKS-----LSEVSAKLT----AKSSELEAVK------ 620
            .:...||:.||::.:::.:....:..:.:|:     ..:.|:..|    |||:..|..:
Human   964 ISEPGNQEKKSEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQFGKKDP 1028

  Fly   621 -----------------ESLASKENT-----------------------IVQLRKEIAILEEAKN 645
                             ..:|:|.||                       :||:.:::.::...:.
Human  1029 NFKGFSGAGEKLFSSQCGKMANKANTSGDFEKDDDACKTEDSDDIHFEPVVQMPEKVELVTGEEG 1093

  Fly   646 GEAAHSLELKEQIDRMQVQV--------------KDAVHSKQQAL-----------------TQN 679
            .:..:|..:|  :.|...::              |:.|:.|.:.|                 |.|
Human  1094 EKVLYSQGVK--LFRFDAEISQWKERGLGNLKILKNEVNGKPRMLMRRDQVLKVCANHWITTTMN 1156

  Fly   680 ---------------KDLEHGVEQAKLEAEQLRLQLSESAQQYESKLNTATQQLLSQTQELEMHL 729
                           .|...|  .||||....:.:..|.|::::.|.....:.||....:....|
Human  1157 LKPLSGSDRAWMWLASDFSDG--DAKLERLAAQFKTPELAEEFKQKFEECQRLLLDIPLQTPHKL 1219

  Fly   730 AEQKRLETALRNAERALEDLRVEYTEYKLKAQSVLRKNQNKGS-----------------NREQE 777
            .:..|....::.||.....|: ::..:....|:.:.:.:||||                 |....
Human  1220 VDTGRAAKLIQRAEEMKSGLK-DFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGPT 1283

  Fly   778 LEEELVALRES--ERNLRASN-----------------------------------DGRAARLAQ 805
            ||.:...|||.  :.|:.:|:                                   ....|:|.|
Human  1284 LEWDNYDLREDALDDNVSSSSVHDSPLASSPVRKNIFRFDESTTGFNFSFKSALSLSKSPAKLNQ 1348

  Fly   806 LDSQI---EELRQDNTDLQKRSKELVSLVDELRQQNDLLSLENQRQLQFQH-------------- 853
            ..:.:   ||  .|.|..::|..:....|..|....::.|.|...|:.|.|
Human  1349 SGTSVGTDEE--SDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAELYRYDKDVGQW 1411

  Fly   854 --------DLMQQH----------RQQVDELDAGHQL---------------------------- 872
                    .::|.:          |.||.:|.|.|::
Human  1412 KERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGER 1476

  Fly   873 ----------------QLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPEQA---KIDYLLMDH 918
                            ...::.::.:.||:..:.::.|.:.|     ::|.::   ||...:::.
Human  1477 KVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRS-----STPRESPCGKIAVAVLEE 1536

  Fly   919 ET--GLDGHAGDVSLAQLAAQRKIST--------------------------ASRRSHDF----- 950
            .|  ..|...|| .:|..|::.::|:                          :|.:|:.|
Human  1537 TTRERTDVIQGD-DVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKSNPFAFGNS 1600

  Fly   951 MPLDELLNTSMNQ--ITSDTVTTISNFGRSVSQQEDEEAEMAARGD---------------FSVQ 998
            .....|...|.|.  .::|:.|:......|.|:.|.::.|::...|               |.::
Human  1601 SATGSLFGFSFNAPLKSNDSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFPME 1665

  Fly   999 SAQL----------------QATKE----RLSIQESRVKHLTALLAENEQDLAKLTQMNDMLKEE 1043
            .:.:                :.|||    :||........|..||.|.|...|.|.:...:||.|
Human  1666 ESSINYTFKTPEKEPPLWHAEFTKEELVQKLSSTTKSADQLNGLLRETEATSAVLMEQIKLLKSE 1730

  Fly  1044 LRRQERSEEREQHMHNSEYLKNVFLKFLTLNNVDERQRLVPVLNTILRLSRNEMEMLNCVAK 1105
            :||.||::  |:...|.|:||||.|:|:.|....||:.|:||:||:|:||..|...|..||:
Human  1731 IRRLERNQ--EESAANVEHLKNVLLQFIFLKPGSERESLLPVINTMLQLSPEEKGKLAAVAQ 1790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	186/1179 (16%)
		TMPIT	458..>548	CDD:285135	25/187 (13%)
		GRIP	1058..1100	CDD:279767	20/41 (49%)
RGPD1	XP_016859592.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12111
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41740
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000