Protein Alignment GCC185 and Numa1

DIOPT Version :10

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: XP_038969271.1
• Gene: Numa1 / 308870
• RGDID: 1308777
• Length: 2114
• Species: Rattus norvegicus
• Alignment Length: 1299
• Identity: 285/1299 - (21%)
• Similarity: 505/1299 - (38%)
• Gaps: 356/1299 - (27%)

  Fly    39 KQAKDELTEE-NHR------LKDALKRAAEKQSSLPAMQEMVQDFTDKNLILTE----------E 86
            ::.|.:|.:| |:|      |.::||...||.:.:..||:.:    |...:|.|          |
  Rat   215 RRLKKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRI----DHLALLNEKQAASPQEPSE 275

  Fly    87 VNNLKRKTKEDADRLTQ-------FEIENESLKRQLGRLSDENDALLANVDRMEKAMQQVNALGN 144
            :..|:.|.:....||.:       .:.|...:.|::.:||:||..|...|......:||:....|
  Rat   276 LEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFANHLQQLQGAFN 340

  Fly   145 EQRKNLELLEVDIAKIKEAEAENASLRQQVAT-------MEEESSVLQQKYQNIKELNSEQRKKF 202
                  :|:|......:|...:.|.|..:::|       :||:|.:||:|...:::..::.:...
  Rat   341 ------DLIEEHSKASQEWAEKQAHLESELSTALQDKKCLEEKSEILQEKISQLEDRAAQLQGSP 399

  Fly   203 NSLKDRFIDVHRKLKNLK--------------------ECK------CVLLETQH---------- 231
            ...|...:....:|..||                    ||:      .:|.|..|
  Rat   400 APEKGEVLGDALQLDTLKQEAAKLATDNTELQARVETLECERGKQEAQLLAERGHFEEEKRQLAS 464

  Fly   232 ------EYAASVSKWQVEIIKASQL----LCAKMASLQAENEKLKLNNGKSDNNPQTIDTGIDRK 286
                  ...:::|:.:.|:.:|||.    |.|::|||.|.|..|:..:.:..:..:....  ::.
  Rat   465 LVADLQSSVSNLSQAKEELQQASQAQGAQLTAQLASLTALNATLQQQDQELTSLKEQAKK--EQA 527

  Fly   287 RLLQRVQEMDRLAKIVKQKQKNQRSNLNVEYLLKKITALEELAVIIKQQHRIDKEQLISVTKEQE 351
            ::||.:||.::.|:.::|:.:...|:|                       ::.::||....||||
  Rat   528 QMLQTLQEQEQAAQGLRQQVEQLSSSL-----------------------KLKEQQLEEAAKEQE 569

  Fly   352 NTK-NHARNLNVSLFQTK------LDQMQNLVKVIAKERDNQQRKLQELEAICIELRQHNEDLLT 409
            ..: :||:.| .::.:.:      .|..:..::.:.||:|.:...||:......|.|...:..:|
  Rat   570 AARQDHAQQL-ATIVEAREASVRERDAARQQLETLEKEKDAKLESLQQQLQASNEARDTAQTSVT 633

  Fly   410 RYHLKEQEHGELLTEMRELNEALKGRGDAISRLQEQHEAEVKRQRDLEAQLSNSQQAA------- 467
            :   .::|..||..::.||:..:    :|..:.|.|.:|.|   .:|||||...||.|
  Rat   634 Q---AQREKAELSQKIGELHACI----EAAHQEQRQAQAHV---TELEAQLKAEQQKATEREKVV 688

  Fly   468 QEKLQKIKQLQSRVEELEQANADAQ------SDVLSTSTISRAEELSRLRELDEGYEEKYHKLRA 526
            |||:|..:|||:..|.|:......:      :|.|........|..:..|.|.|..|::..:|..
  Rat   689 QEKVQLQEQLQALEETLKIVRGSLEEEKCRAADALKEQQRHATEMEAETRHLMEQREQEQKELEQ 753

  Fly   527 IAAKLKKKLQEQTQQLNEMEQ--SGALKEELEAIKLAQ--------------------------- 562
            ..|: :|.|:.:.|||.|..|  :.||:.||.....||
  Rat   754 EKAE-RKGLEARLQQLEEAHQAETEALRHELAGATAAQHGAESEREQLLREVESWQKRVEARQQE 817

  Fly   563 -----AQLQQDLNAARAENQKLKSKEKVKHSSV---------------LNLEIEAAEKSLSEVSA 607
                 |..|:.|.|.:.|:.|:..:|:.:...:               |:..:..|.:.:.|..|
  Rat   818 EARYGAMFQEQLMALKGEHGKIGQEEQKEAGEIHGEGQTGQQQSQLAQLHACLAKALQQVQEKEA 882

  Fly   608 KLTAKSSELEAVKESLASKENTIVQLRKEIAILEEAKNGEAAHSLELKE-------QIDRMQVQV 665
            :......:|.|::|.:|:....:..|:   |::.:|...:||.|.||||       :.|..:.|.
  Rat   883 RAQKLLDDLSALREKMAATNKEVACLK---ALVLKAGEQQAAASHELKEPPRAGNQESDWEEEQA 944

  Fly   666 KDAVHSKQQALTQNKDLEHGVEQAKLEAEQLRLQLSESAQQYESKLNTATQQLLSQTQE---LEM 727
            : .:.|.|.||   |.::...||...|.|:||..|.:|..|.:.......:::...|||   .:.
  Rat   945 R-PLGSTQAAL---KAVQREAEQMGGELERLRAALMQSQGQQQEVRGQQEREVARLTQERGQAQA 1005

  Fly   728 HLAEQK----RLETALRNAERALEDLRVEYTEYKLKAQSVLRKNQNKGSNREQELEEELVALRES 788
            .||::|    .||..|:|   .|.:.|||:...:......:.:.:.|        ::||..|||.
  Rat  1006 DLAQEKAAKAELEMRLQN---TLNEQRVEFAALQEALTHAMTEKEGK--------DQELAKLREQ 1059

  Fly   789 ERNLRASNDGRAARLAQLDSQIEELRQDNTDLQKRSKELVS------------------------ 829
            |          ||::    |:::.|:|...:|:|:.||..:
  Rat  1060 E----------AAQI----SELKALQQTLEELKKKEKEHPTGGARGEDASGDGPGSQLHTPGKTE 1110

  Fly   830 ----LVDELRQQNDLLSLENQRQLQFQHDLMQQHRQQVDELDAGHQLQ------------LTQVQ 878
                .|:.||.  ::..||.|         .||.:|||:.|.  |.|:            |..:|
  Rat  1111 APGPEVEALRA--EISKLERQ---------WQQQQQQVEGLT--HSLESERACRAEQDKALETLQ 1162

  Fly   879 EQLEEAQKMQANVSQHTTASAASVDTSPEQAKIDYL---LMDHETGLDGHAGDVSLAQLAAQRKI 940
            .||||    :|....|..|::||.     |.::..|   ..||....:.....|:..|..|:||.
  Rat  1163 GQLEE----KARELGHNQAASASA-----QRELQALRAKAQDHSKAEEEWKAQVARGQQEAERKS 1218

  Fly   941 STASRRSHDFMPLDELLNTSMNQITSDTVTTISNFGRSVSQQEDEEAEMAARGDFSVQSAQLQAT 1005
            |..|       .|:|               .:|...|.|.::|.|..|:  :.....:|.:.|..
  Rat  1219 SLIS-------SLEE---------------EVSILNRQVLEKEGESKEL--KRLVVAESEKSQKL 1259

  Fly  1006 KERLSI-------QESRVKHLTALLAENEQDLAKLTQMNDMLKEELRRQ-----ERSEEREQHM- 1057
            :|||.:       ..:|....::.|.|..|.|.:..:...::.|.||::     ||:||..|.:
  Rat  1260 EERLRLLQVETASSSARAAERSSALREEVQSLREEVEKQRVVSENLRQELASQAERAEESGQELK 1324

  Fly  1058 --HNSEYLKNVFLKFLTLNNVDER---QRLVPVLNTILRLS----------RNEMEMLNCVAKG 1106
              ....:.|...|..|.|.:...:   ..|:|..:...:|.          |.|:|.....|.|
  Rat  1325 AWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRFREEIEQSKQAAGG 1388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	PRK03918	<33..559	CDD:235175	138/618 (22%)
		Smc	<357..>920	CDD:440809	160/687 (23%)
		Grip	1057..1103	CDD:197860	10/61 (16%)
Numa1	XP_038969271.1	HkD_NuMA	6..151	CDD:411795
		PRK02224	<243..738	CDD:179385	113/540 (21%)
		SMC_prok_B	530..1321	CDD:274008	207/903 (23%)
		Smc	<1115..>1633	CDD:440809	74/320 (23%)
		MreC	<1613..>1674	CDD:480808
		PHA03307	1735..>2018	CDD:223039
		NuMA_LGNBD	1872..1930	CDD:412093