DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCC185 and Ranbp2

DIOPT Version :9

Sequence 1:	NP_001097755.1	Gene:	GCC185 / 41459	FlyBaseID:	FBgn0037979	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	XP_038954525.1	Gene:	Ranbp2 / 294429	RGDID:	1560047	Length:	3114	Species:	Rattus norvegicus

Alignment Length:	1107	Identity:	209/1107 - (18%)
Similarity:	383/1107 - (34%)	Gaps:	288/1107 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QKNPNPIEALS--KDEIISKYKGLLNIAKKAKQAKDELTEENHRLKDALKRAAEKQSSLPAMQEM 72
            :|:|| .:..|  .:::.|...|  .:|:||..:..|..::.::.:|:.....|....:|...|:
  Rat  1839 KKDPN-FKGFSGAGEKLFSSQSG--KVAEKANTSDLEKDDDAYKTEDSDDIHFEPVVQMPEKVEL 1900

  Fly    73 VQDFTDKNLILTEEVNNLKRKTKEDADRLTQFEIENESLKRQLGRLSDENDALLANVDRMEKAMQ 137
            |....|:.::.::.|            :|.:|:.|....|                    |:.:.
  Rat  1901 VTGEEDEKVLYSQRV------------KLFRFDAEISQWK--------------------ERGLG 1933

  Fly   138 QVNALGNEQRKNLELLEVDIAKIKEAEAENASLRQQVATMEEESSVLQQKYQNIKELNSEQRKKF 202
            .:..|.||....|.:|      ::..:.........:.|.           .|:|.|:...| .:
  Rat  1934 NLKILKNEVNGKLRML------MRREQVLKVCANHWITTT-----------MNLKPLSGSDR-AW 1980

  Fly   203 NSLKDRFIDVHRKLKNL-----------------KECKCVL----LETQHEYAASVSKWQVEIIK 246
            ..|...|.|...||:.|                 :||:.:|    |:|.|:.        |:..:
  Rat  1981 MWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKL--------VDTGR 2037

  Fly   247 ASQLL--CAKMASLQAENEKLKLNNGKSDNNPQTIDTGIDRKRLLQRVQEMDRLAKIVKQKQKNQ 309
            |::|:  ..:|.|...:.:....|:.......:...:|.|........         |||...|.
  Rat  2038 AAKLIQRAEEMKSGLKDFKTFLTNDQAKVTEEENTSSGADASSASDTT---------VKQNPDNT 2093

  Fly   310 RSNLNVEYLLKKITALEE-------------LAVIIKQQHRIDKEQL---ISVTKEQENTKNHAR 358
            ...|..:....:..||::             .:.:.|...|..:...   .|.......:|:.|:
  Rat  2094 GPALEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKSPAK 2158

  Fly   359 NLNVSLFQTKLDQMQNLVKVIAKERDNQQRK----LQELEAICIELRQHNEDLLTRYHLKEQEHG 419
             ||.|......|:..::.:  .:|||.|..:    |.:|  |.:...:.||.::..:..|...:.
  Rat  2159 -LNQSGTSVGTDEESDVTQ--EEERDGQYFEPVVPLPDL--IEVSSGEENEQVVFSHRAKLYRYD 2218

  Fly   420 ELLTEMRELNEALKGRGDAISRLQEQHEAEVK--RQRDLEAQL-SNSQQAAQEKLQKIKQL---- 477
            :.:.:.:|     :|.|| |..||.....:|:  .:||...:| :|.:......||.:|..
  Rat  2219 KDVGQWKE-----RGIGD-IKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQTMKGTERVW 2277

  Fly   478 ----------QSRVEEL-----------------EQANADAQSDVLSTSTISRAEELSRLRELDE 515
                      :.::|.|                 ::|....:.|.|.|..:|   .||..||...
  Rat  2278 VWTACDFADGERKIEHLAVRFKLQDVADSFKKIFDEAKTAQEKDCLITPHVS---HLSTPRESPC 2339

  Fly   516 GYEEKYHKLRAIAAKLKKKLQEQTQQLNEMEQSGALKEELEAIKLAQAQLQQDLNAARAENQKLK 580
            |      |: |||.     |:|.|::..::.|...:.:.........:..:....|..:..:.:.
  Rat  2340 G------KI-AIAV-----LEETTRERTDLTQGDEVVDTTSEAGETSSTSETTPKAVVSPPKFVF 2392

  Fly   581 SKEKVKHSSVLNLEIEAAEKSLSEVSAKLTAKSS----ELEAVKESLASKENTIVQLRKEIAILE 641
            ..|.||       .|.::|||........:|..|    ...|..::..|:.::|||...|..:
  Rat  2393 GSESVK-------SIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKNSNSEISSIVQSGSEGKV-- 2448

  Fly   642 EAKNGEAAHSLELKEQIDRMQVQVKDAVHSKQQALTQNKDLEHGVEQAKLEAEQLRLQLSESAQQ 706
            :...||...:.::|:..|.   :||:.:...::..:..|..|.|...:..::..:....|....|
  Rat  2449 DPDKGELPPNSDIKQSSDG---KVKNLIAFSKETSSTFKTPEKGFNFSLFKSNPMAFWTSIPTSQ 2510

  Fly   707 YESKL--NTATQQLLSQTQELEMH----LAEQKRLETALRNAERALEDLRVEYTEYKLKAQSVLR 765
            .|||.  ....:...|.|..|.::    ..|||.|      ||:.|           |.:.....
  Rat  2511 PESKAREKNKPEDPPSDTDILIVYELTPTPEQKAL------AEKLL-----------LPSTFFCY 2558

  Fly   766 KNQNKGSNREQELEEEL-VALRESERNLRASNDGRAARLAQLDSQIEELRQDNTDLQKRSKELVS 829
            ||:....:.|:|.:|:. :|:::....|...:.         :..:||...||      .||.|.
  Rat  2559 KNRPGYVSEEEEDDEDFEMAVKKLNGKLYVDDS---------EKPLEENLADN------DKECVI 2608

  Fly   830 LVD-----ELRQQNDLLSL--------------ENQRQLQFQHDLMQ-QHRQQVDELDAGHQLQL 874
            :.:     |.|.:.|.|.|              :|.....||.:|.: |..|:.......:.:.:
  Rat  2609 VWEKKPTVEERAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELRKVQEAQKSQSEKVTNTVGI 2673

  Fly   875 TQVQEQLEEAQKMQANVSQHTTASAASVDTSPEQAKIDY---LLMDHETGLD------------- 923
            .|..|  .||.....:.|:...:......:||....:|.   |....||.::
  Rat  2674 EQTGE--TEATNPDGSKSEEPDSDTKHSSSSPVPGTMDKPVDLSTKKETDMEFPSQGESKTVLFG 2736

  Fly   924 -GHAGDVSLAQLAAQRKISTASRRSHDFM--PLDELLNTSMNQITSDTVTTISNFG-RSVSQQED 984
             |....:|.|.|        ||..|.||.  |.|:      |...::|...:  || :|.|:..|
  Rat  2737 FGSGTGLSFADL--------ASSNSGDFAFGPKDK------NFQWANTGAAV--FGTQSTSKDGD 2785

  Fly   985 EE 986
            :|
  Rat  2786 DE 2787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	156/865 (18%)
		TMPIT	458..>548	CDD:285135	24/121 (20%)
		GRIP	1058..1100	CDD:279767
Ranbp2	XP_038954525.1	TPR	<18..126	CDD:223533
		TPR repeat	59..89	CDD:276809
		RanBD1_RanBP2-like	1180..1296	CDD:270203
		zf-RanBP	1345..1374	CDD:395516
		RanBP2-type Zn finger	1350..1369	CDD:275375
		zf-RanBP	1410..1438	CDD:395516
		RanBP2-type Zn finger	1414..1433	CDD:275375
		zf-RanBP	1473..1502	CDD:395516
		RanBP2-type Zn finger	1477..1496	CDD:275375
		zf-RanBP	1533..1563	CDD:395516
		RanBP2-type Zn finger	1537..1556	CDD:275375
		zf-RanBP	1596..1625	CDD:395516
		RanBP2-type Zn finger	1600..1619	CDD:275375
		zf-RanBP	1655..1683	CDD:395516
		RanBP2-type Zn finger	1659..1678	CDD:275375
		RanBD2_RanBP2-like	1902..2018	CDD:269998	24/165 (15%)
		RanBD3_RanBP2-like	2199..2315	CDD:270204	20/121 (17%)
		IR1-M	2529..2590	CDD:403422	16/77 (21%)
		IR1-M	2605..2663	CDD:403422	13/57 (23%)
		RanBD4_RanBP2-like	2815..2931	CDD:269999
		cyclophilin_ABH_like	2954..3112	CDD:238907
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900