DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCC185 and RGPD4

DIOPT Version :9

Sequence 1:	NP_001097755.1	Gene:	GCC185 / 41459	FlyBaseID:	FBgn0037979	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	NP_872394.2	Gene:	RGPD4 / 285190	HGNCID:	32417	Length:	1758	Species:	Homo sapiens

Alignment Length:	1512	Identity:	274/1512 - (18%)
Similarity:	523/1512 - (34%)	Gaps:	497/1512 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PNPIEALSKDEIISKYKGLLNIAKKAKQAKDELTEENHRL-------KDALKRAAE---KQSSLP 67
            |.|...|.|.|   ..:.||.:     .|.|.|::..|.|       :|.||...|   .:|...
Human   328 PRPKIKLIKGE---AGQNLLEM-----MACDRLSQSGHMLLNLSRGKQDFLKVVVETFANKSGQS 384

  Fly    68 AMQEMV---QDFTDKNLILTEEVNNLKRKTKEDADRLTQFEI-----ENESLKR--QLGRLSDEN 122
            |:.:.:   |...|.:.:.::::.|:..:..|..| |.::::     .|.||:.  .|| |...:
Human   385 ALYDALFSSQSPKDTSFLGSDDIGNIDVQEPELED-LARYDVGAIRAHNGSLQHLTWLG-LQWNS 447

  Fly   123 DALLANVDRMEKAM-----QQVNALGNEQRKNLELLEVDIAKIKEAEAENASLRQQVATMEEESS 182
            ...|..:.:..|.:     |:.:.|.....:::.:|::::..:......:..|:::..:......
Human   448 LPALPGIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQ 512

  Fly   183 VLQQKYQNIKELNSEQRKKF---------------NSLKDRFIDVHRKLKNLKE----------- 221
            .|.......|:|.:|::|.:               ||.|.|.: |..::..|:.
Human   513 PLCLPLPVCKQLCTERQKSWWDAVCTLIHRKAVPGNSAKLRLL-VQHEINTLRAQEKHGLQPALL 576

  Fly   222 ---CKCV--------LLETQHEY-AASVSKWQ-----VEIIKASQLLCAKMASLQAENEKLKLNN 269
               .||:        ....|.|| ..||..|:     ::|||
Human   577 VHWAKCLQKMGSGLNSFYDQREYIGRSVHYWKKVLPLLKIIK----------------------- 618

  Fly   270 GKSDNNPQTIDTGIDRKRLLQRVQEMD-RLAKIVKQKQKNQRS-------NLNVE------YLLK 320
             |.::.|:.||.      |.:....:| :.::||:.::....:       |.|:|      ..:|
Human   619 -KKNSIPEPIDP------LFKHFHSVDIQASEIVEYEEDAHVTFAILDAVNGNIEDAMTAFESIK 676

  Fly   321 KITALEELAVIIKQQHRIDKEQLISVTKEQENTKNHAR---------------NLN-VSLFQTKL 369
            .:.:...||:|..::........:| .:|||..||:.|               ||: |......|
Human   677 SVVSYWNLALIFHRKAEDIANDALS-PEEQEECKNYLRKTRGYLIKILDDSDSNLSVVKKLPVPL 740

  Fly   370 DQMQNLVKVIAKERDNQQR-----KLQELEAICIELRQHNEDLLTRYHLKEQEHGELLTE----- 424
            :.::.::|.:.:|.:|...     |...|.....|:: |:....|:|.|...:..:...:
Human   741 ESVKEMLKSVMQELENYSEGDPLYKNGSLRNADSEIK-HSTPSPTKYSLSPSKSYKYSPKTPPRW 804

  Fly   425 MRELNEALKGRGDAISRLQEQHEAEVKRQRDLEAQLSNSQQAAQEKLQKIKQLQSRVEELEQANA 489
            ..:.|..||.....:..::|:.:         |.:|::|:.|:..:..........|.:..|.:.
Human   805 AEDQNSLLKMIRQEVKAIKEEMQ---------ELKLNSSKSASHHRWPTENYGPDSVPDGYQGSQ 860

  Fly   490 DAQSDVLSTSTISRAEELSRLRELDEGYEEKYHKLRAIAAKLKKKLQEQTQQLNEMEQSGALKEE 554
            ......|:.:|...:...|:    ...|..:| .||..|.....|....|:          .|..
Human   861 TFHGAPLTVATTGPSVYYSQ----SPAYNSQY-LLRPAANVTPTKGSSNTE----------FKST 910

  Fly   555 LEAIKLAQAQLQQDLNAARAENQKLKSKEKVKHSSVLNLEIEAAEKS-----LSEVSAKLT---- 610
            .|...:..:........:...||:.:|::.:::.:....:..:.:|:     ..:.|:..|
Human   911 KEGFSIPVSADGFKFGISEPGNQEKESEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADV 975

  Fly   611 AKSSELEAVK-----------------------ESLASKENT----------------------- 629
            |||:..|..:                       ..:|:|.||
Human   976 AKSTSGEGFQFGKKDPNFKGFSGAGEKLFSSQCGKMANKANTSGDFEKDDDAYKTEDSDDIHFEP 1040

  Fly   630 IVQL--RKEIAILEEAKNGEAAHSLEL----------KEQ-IDRMQVQVKDAVHSKQQAL----- 676
            :||:  :.|:.|.||.:....:..::|          ||: :..::: :|:.|:.|.:.|
Human  1041 VVQMPEKVELVIGEEGEKVLYSQGVKLFRFDAEVRQWKERGLGNLKI-LKNEVNGKPRMLMRREQ 1104

  Fly   677 ------------TQN---------------KDLEHGVEQAKLEAEQLRLQLSESAQQYESKLNTA 714
                        |.|               .|...|  .||||....:.:..|.|::::.|....
Human  1105 VLKVCANHWITTTMNLKPLSGSDRAWMWSASDFSDG--DAKLERLAAKFKTPELAEEFKQKFEEC 1167

  Fly   715 TQQLLSQTQELEMHLAEQKRLETALRNAERALEDLRVEYTEYKLKAQSVLRKNQNKGS------- 772
            .|.||....:....|.:..|....::.||.....|: ::..:....|:.:.:.:||||
Human  1168 QQLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLK-DFKTFLTNDQTKVTEEENKGSGTGAAGA 1231

  Fly   773 ----------NREQELEEELVALRE-------SERNLRAS------------NDGRA-------- 800
                      |....||.:...|||       |..::.||            :.|.:
Human  1232 SDTTIKPNPENTGPTLEWDNCDLREDALDDSVSSSSVHASPLASSPVRKNLFHFGESTTGSNFSF 1296

  Fly   801 ----------ARLAQLDSQI---EELRQDNTDLQKRSKELVSLVDELRQQNDLLSLENQRQLQFQ 852
                      |:|.|..:.:   ||  .|.|..::|..:....|..|....::.|.|...::.|.
Human  1297 KSALSPSKSPAKLNQSGTSVGTDEE--SDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEKVVFS 1359

  Fly   853 H----------------------DLMQQH----------RQQVDELDAGHQL------------- 872
            |                      .::|.:          |.||.:|.|.|.:
Human  1360 HRAELYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHTITPDMSLQNMKGTE 1424

  Fly   873 -------------------------------QLTQVQEQLEEAQKMQANVSQHTTASAASVDTSP 906
                                           ...::.::.:.||:..:.::.|.:.|     ::|
Human  1425 RVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRS-----STP 1484

  Fly   907 EQA---KIDYLLMDHET--GLDGHAGDVSLAQLAAQRKIST------------------------ 942
            .::   ||...:::..|  ..|...|| .:|..|::.::|:
Human  1485 RESPCGKIAVAVLEETTRERTDVIQGD-DVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKR 1548

  Fly   943 --ASRRSHDF-----MPLDEL----LNTSMNQITSDTVTTISNFGRSVSQQEDEEAEMAARGD-- 994
              :|.:|..|     .....|    .|.|:....|:| ::::..| |.|:.|.::.|::...|
Human  1549 IFSSEKSKPFAFGNSSATGSLFGFSFNASLKSNNSET-SSVAQSG-SESKVEPKKCELSKNSDIE 1611

  Fly   995 -------------FSVQSAQL----------------QATKE----RLSIQESRVKHLTALLAEN 1026
                         |.::.:.:                :.|||    :||.......||..||.|.
Human  1612 QSSDSKVKNLSASFPMEESSINYTFKTPEKEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLREA 1676

  Fly  1027 EQDLAKLTQMNDMLKEELRRQERSEEREQHMHNSEYLKNVFLKFLTLNNVDERQRLVPVLNTILR 1091
            |...|.|.:...:||.|:||.||::|:|:...|.|:||||.|:|:.|....||:||:||:||:|:
Human  1677 EATSAVLMEQIKLLKSEIRRLERNQEQEESAANVEHLKNVLLQFIFLKPGSERERLLPVINTMLQ 1741

  Fly  1092 LSRNEMEMLNCVAKGQK 1108
            ||..|...|..||:|::
Human  1742 LSPEEKGKLAAVAQGEE 1758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	174/1042 (17%)
		TMPIT	458..>548	CDD:285135	15/89 (17%)
		GRIP	1058..1100	CDD:279767	21/41 (51%)
RGPD4	NP_872394.2	TPR_11	59..126	CDD:290150
		TPR repeat	59..89	CDD:276809
		TPR 1	60..93
		TPR	60..92	CDD:197478
		TPR 2	584..617		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..805		7/44 (16%)
		YRB1	976..1169	CDD:227499	32/195 (16%)
		RanBD2_RanBP2-like	1053..1168	CDD:269998	20/117 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1213..1249		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1295..1332		8/38 (21%)
		RanBD3_RanBP2-like	1349..1465	CDD:270204	11/115 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1583..1621		8/39 (21%)
		Rab_bind	1642..1706	CDD:293309	22/63 (35%)
		GRIP	1708..1750	CDD:279767	21/41 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12111
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41740
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.900