Protein Alignment GCC185 and GOLGA3

DIOPT Version :10

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: NP_005886.2
• Gene: GOLGA3 / 2802
• HGNCID: 4426
• Length: 1498
• Species: Homo sapiens
• Alignment Length: 1260
• Identity: 274/1260 - (21%)
• Similarity: 496/1260 - (39%)
• Gaps: 340/1260 - (26%)

  Fly     4 ASPRETQKNPNPIEALSKDEIISKYKGLLNIAKKAKQAKDELTEENHRLKDALKRAAEKQSSLPA 68
            :|..|||:.                  :|.:.|:..:.:.:|...:.....|||..||.|:.|.|
Human   398 SSAAETQEE------------------MLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAA 444

  Fly    69 MQEMVQDFTDKNLILTEEVNNLKRKTKEDADRLTQFEIENESLKRQLGRLSDENDALLANVDRME 133
            :...:|                           .|.|..:.|.:|| ..||.|.|.|..:...:|
Human   445 LSTKLQ---------------------------AQVECSHSSQQRQ-DSLSSEVDTLKQSCWDLE 481

  Fly   134 KAMQQVNALGNEQRKNLELLEVDIAKIKEAEAENASLRQQVATMEEESSVLQQKYQNIKELNSEQ 198
            :||..:..:                    .||:||||    |:...:..|.:::||.:.....:.
Human   482 RAMTDLQNM--------------------LEAKNASL----ASSNNDLQVAEEQYQRLMAKVEDM 522

  Fly   199 RKKFNSLKDRFIDVHRKLKNLKECKCVLLETQHEYAASVSKWQVEIIKASQLLCAKMASLQAENE 263
            ::...| ||.  .||...:.:...:..|.:.|.|.....||     :||||   |:::|||:
Human   523 QRSMLS-KDN--TVHDLRQQMTALQSQLQQVQLERTTLTSK-----LKASQ---AEISSLQS--- 573

  Fly   264 KLKLNNGKSDNNPQTIDTGIDRKRLLQRVQEMDRLAKIVKQKQKNQRSNLNV---------EYL- 318
                                    :.|..|:...||:..:.:.:.:.:::.|         |:|
Human   574 ------------------------VRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLK 614

  Fly   319 LKKITALEELAVIIKQQHRIDKE------QLISVTKEQENTKNHARNLNVSLFQTKLDQ-MQNLV 376
            |:.::..::|.   :.|||..||      ||..:  |.:.....|..:.:...:|.::: :|..:
Human   615 LENVSLSQQLT---ETQHRSMKEKGRIAAQLQGI--EADMLDQEAAFMQIQEAKTMVEEDLQRRL 674

  Fly   377 KVIAKERDNQQRKL-------QELEAICIELRQHNEDLLTRYHLKEQEHGELLTEMRELNEALKG 434
            :....||:..||..       |:||.:.:.|.|.::.|    ...:|||.:|:.::....|||:.
Human   675 EEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQL----EALQQEHLDLMKQLTLTQEALQS 735

  Fly   435 RGDAISRLQEQHEAEVKRQRDLEAQLSNSQQAAQEKLQKIKQLQSRVEELEQANADAQSDVLSTS 499
            |..::..||..::       :|:|:|...|..|..:...|..||:....||.|...|:|.
Human   736 REQSLDALQTHYD-------ELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSG----- 788

  Fly   500 TISRAEELSR-LRELDEGYEEKYHKLRAIAAKLKKKLQEQTQQLNEMEQ-SGALKEELEAIKLAQ 562
                .|||.| .|.|:||.||....|.    ||:::|..::.|:..::| :.|||::::.||  :
Human   789 ----KEELDRGARRLEEGTEETSETLE----KLREELAIKSGQVEHLQQETAALKKQMQKIK--E 843

  Fly   563 AQLQQDLNAARAENQKLKSKEKVKHSSVLNLEIEAAEK----SLSEVSAKLTAKSSELEAVKESL 623
            ..|||.: ...|..:...||::      |..|::|..|    .|.|:..:|.....|....:..|
Human   844 QFLQQKV-MVEAYRRDATSKDQ------LISELKATRKRLDSELKELRQELMQVHGEKRTAEAEL 901

  Fly   624 ASKENTIVQLRKEIAILEEAKNGEAAHSLELKEQIDRMQVQVKDAVHSKQQ--ALTQ-NKDLEHG 685
            :.....:.|:|:.:|.||       .|....:::.|.|:..::.....|:|  |:|: |:.|:..
Human   902 SRLHREVAQVRQHMADLE-------GHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQ 959

  Fly   686 VEQAKLEAEQLRLQLSESAQQYESKLNTATQQLLSQTQELEMHLA-EQKRLETALRNAERALEDL 749
            :|:.:.||.:...:..:..::..|.|.:|.:::.::.:..|..:. ..:||:.||...|.|..:|
Human   960 IEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAEL 1024

  Fly   750 ------------------RVEYTEYKLKA----QSVLRK---------NQNKGSNREQ--ELEEE 781
                              |::..|.:|:|    :::|.|         :|....:||:  |||:|
Human  1025 GQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDE 1089

  Fly   782 L----------VALRESERNLRASNDGRAARLAQLDSQIEELRQDN----TDLQKRSKELVSL-- 830
            |          ..|.||.:.|....:....:|..|......||:.|    |.|.||..:||.|
Human  1090 LQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNL 1154

  Fly   831 -VDELRQQNDLLSLENQRQL----QFQHDLMQQHRQQVDEL---------DAGH--------QLQ 873
             |..:.|:.:    |..||:    |.....:::.:::|:.|         :|||        .|:
Human  1155 QVQAVLQRKE----EEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLE 1215

  Fly   874 LTQVQEQLEE----AQKMQANVSQHTTASAASVDTSPEQAKIDYLLMDHETGLDGHAGDVS---- 930
            |::|:::|:.    .||:||...          |....:.|              |:.:::
Human  1216 LSEVKKELQAKEHLVQKLQAEAD----------DLQIREGK--------------HSQEIAQFQA 1256

  Fly   931 -LAQLAAQRKISTASRRSHDFMPLDELLNTSM--NQITSDTVTTISNFGRSVSQQEDEEAEMAAR 992
             ||:..||.::....        |||.|:...  ||       .:.|....|.|:|.|...:..:
Human  1257 ELAEARAQLQLLQKQ--------LDEQLSKQPVGNQ-------EMENLKWEVDQKEREIQSLKQQ 1306

  Fly   993 GDFSVQ----------------SAQLQATKERLSIQESRVKHLTALLAENEQDLAKLTQMNDMLK 1041
            .|.:.|                .::|:..:|.||:.:.....|.|.::|.:.::..|.|.|..||
Human  1307 LDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLK 1371

  Fly  1042 EELRRQERSEEREQHMHNSEYLKNVFLKF----LTLNNVDERQRLVPV--------LNTILRLSR 1094
            .:|||......:|.....|.......:|.    :..:.::|..|..|.        ||:.|:..:
Human  1372 LDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLK 1436

  Fly  1095 NEMEMLNCVAKGQKVSADGSSRSWT 1119
            .||:.|....:...::...|..|||
Human  1437 QEMDSLQRQMEEHALTVHESLSSWT 1461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	PRK03918	<33..559	CDD:235175	124/551 (23%)
		Smc	<357..>920	CDD:440809	151/655 (23%)
		Grip	1057..1103	CDD:197860	11/57 (19%)
GOLGA3	NP_005886.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		Interaction with GOPC. /evidence=ECO:0000269|PubMed:15951434	121..141
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..195
		Golgi-targeting domain	172..257
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..325
		SMC_prok_B	<345..982	CDD:274008	163/736 (22%)
		SMC_prok_B	668..1339	CDD:274008	169/753 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	789..809		10/19 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	974..993		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1376..1400		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1440..1498		5/22 (23%)