DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCC185 and Golga3

DIOPT Version :9

Sequence 1:	NP_001097755.1	Gene:	GCC185 / 41459	FlyBaseID:	FBgn0037979	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	NP_001334318.1	Gene:	Golga3 / 269682	MGIID:	96958	Length:	1487	Species:	Mus musculus

Alignment Length:	1283	Identity:	281/1283 - (21%)
Similarity:	487/1283 - (37%)	Gaps:	357/1283 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EALSKDEIISKYKGLLNIAKKAKQAKDELTEENHRL---KDALKRAAEKQSSLPAMQ-EMVQDFT 77
            |||.:   ....|.:|..|  |.|.:|:..|.|..:   :|::..:...:|||...| |::|...
Mouse   349 EALGQ---FPSIKDVLQAA--AAQHQDQNQEANGEVRSRRDSICSSVSMESSLAEPQDELLQILK 408

  Fly    78 DKNLILTEEVNNLKRKTKEDADRLTQFEIENESLKRQLGRLSDENDALLANVDRMEKAMQQVNAL 142
            ||.. |..:|..|..    :|.:..|   |...|:.||..||..   |.|.|:....:.|:.::|
Mouse   409 DKRR-LEGQVEALSL----EASQALQ---EKAELQAQLAALSTR---LQAQVEHSHSSQQKQDSL 462

  Fly   143 GNEQRK------NLELLEVDIAKIKEAEAENASLRQQVATMEEESSVLQQKYQNIKELNSEQRKK 201
            .:|...      :||....|:..:  .||:||||    |:...:..|.:::||.:.....:.::.
Mouse   463 SSEVDTLKQSCWDLERAMTDLQSM--LEAKNASL----ASSNNDLQVAEEQYQRLMAKVEDMQRN 521

  Fly   202 FNSLKDRFIDVHRKLKNLKECKCVLLETQHEYAASVSKWQVEIIKASQLLCAKMASLQAENEKLK 266
            ..| ||.  .||...:.:...:..|.:.|.|.....||     ::|||   |::.|||
Mouse   522 ILS-KDN--TVHDLRQQMTALQSQLQQVQLERTTLTSK-----LQASQ---AEITSLQ------- 568

  Fly   267 LNNGKSDNNPQTIDTGIDRKRLLQRVQEMDRLAKIVKQKQKNQRSNLNV---------EYL-LKK 321
                                ...|..|:...||:..:.:.:.:.:::.|         |:| |:.
Mouse   569 --------------------HARQWYQQQLTLAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLEN 613

  Fly   322 ITALEELAVIIKQQHRIDKE------QLISVTKEQENTK------NHARNLNVSLFQTKLDQMQN 374
            ::...:|.   :.|||..||      ||.|:..:..:.:      ..|:.:.....|.:|::.:.
Mouse   614 VSLSHQLT---ETQHRSIKEKERIAVQLQSIEADMLDQEAAFVQIREAKTMVEEDLQRRLEEFEG 675

  Fly   375 LVKVIAKERDNQQRKLQELEAICIELRQHNEDLLTRYHLKEQEHGELLTEMRELNEALKGRGDAI 439
            ..:.:.|..|......|:||.:.:.|.|.::.|..    .:|||.:::.::....|||:.:|.::
Mouse   676 EREQLQKVADAAASLEQQLEQVKLTLFQRDQQLAA----LQQEHLDVIKQLTSTQEALQAKGQSL 736

  Fly   440 SRLQEQHEAEVKRQRDLEAQLSNSQQAAQEKLQKIKQLQSRVEELEQANADAQSDVLSTSTISRA 504
            ..|..:::       :|:|:|...|:.|..:...|..||:....||.|...|:||         .
Mouse   737 DDLHTRYD-------ELQARLEELQREADSREDAIHFLQNEKIVLEVALQSAKSD---------K 785

  Fly   505 EELSR-LRELDEGYEEK---YHKLR---AIAAKLKKKLQEQTQQLNEMEQSGALKEE-------L 555
            |||.| .|.|:|..||.   ..:||   |:.:...:.||::|..|.:..|.  :||:       :
Mouse   786 EELDRGARRLEEDTEETSGLLEQLRQDLAVKSNQVEHLQQETATLRKQMQK--VKEQFVQQKVMV 848

  Fly   556 EAIKLAQAQLQQDLNAARAENQKLKSKEKVKHSSVLNL-------EIEAA--EKSLSEVSAKLTA 611
            ||.:.......|.:|..:|..::|.|:.|.....::.|       |:|.:  :|.:|.|..::..
Mouse   849 EAYRRDATSKDQLINELKATKKRLDSEMKELRQELIKLQGEKKTVEVEHSRLQKDMSLVHQQMAE 913

  Fly   612 KSSELEAVKESLASKENTIVQL---RKEIAILEEAKNGEAAHSLELKEQIDRMQVQVKDAVHSKQ 673
            ....|::|::.....|..:..|   ::::..|.||..       .||:||:.:|.:.|.|:..::
Mouse   914 LEGHLQSVQKERDEMEIHLQSLKFDKEQMIALTEANE-------TLKKQIEELQQEAKKAITEQK 971

  Fly   674 QAL---------------TQNKDLEHGV--------------EQAKLEAEQLRLQ---------L 700
            |.:               |::|..|:.|              |....|..|||.|         |
Mouse   972 QKMKRLGSDLSSAQKEMKTKHKAYENAVSILSRRLQEALASKEATDAELNQLRAQSTGGSSDPVL 1036

  Fly   701 SESAQQYESKLNTATQQLLSQTQEL---------EMHLAEQKRLETALRNAERALEDLRVEYTEY 756
            .|..:..|.:|....|..:...:||         |:..:.:|.||         |||...|...:
Mouse  1037 HEKIRALEVELQNVGQSKILLEKELQEVITMTSQELEESREKVLE---------LEDELQESRGF 1092

  Fly   757 KLKAQSVLRKNQNKGSNREQE------LEEELVALRESERNLRASNDGRAARLAQLDSQIEELRQ 815
            :.|.:.:...|:......|.|      |.:...||||....|..:...|.|.|.||:.|::.:.|
Mouse  1093 RRKIKRLEESNKKLALELEHERGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQ 1157

  Fly   816 DNTDLQKRSKEL-----VSLVDELRQQNDL----------------------LSL-ENQRQLQFQ 852
            ...:..::.|:|     |||..|..:.|.|                      |.| |.:::||.:
Mouse  1158 RKEEEDRQMKQLVQALQVSLEKEKMEVNSLKEQMAAARIEAGHNRRHFKAATLELSEVKKELQAK 1222

  Fly   853 HDLMQQHRQQVDEL---DAGHQLQLTQVQEQLEEA--------QKMQANVSQHTTASAASVDTSP 906
            ..|:|..:.:||||   |..|..::.|.|.:|.||        :|:...:||..|.|....|...
Mouse  1223 EHLVQTLQAEVDELQIQDGKHSQEIAQFQTELAEARTQLQLLQKKLDEQMSQQPTGSQEMEDLKW 1287

  Fly   907 EQAKIDYLLMDHETGLDGHAGDVSLAQLAAQRKISTASRRSHDFMPLDELLNTSMNQITSDTVTT 971
            |        :|.:                 :|:|.:..::    :.|.|.......:.|..|:.|
Mouse  1288 E--------LDQK-----------------EREIQSLKQQ----LDLTEQQGKKELEGTQQTLQT 1323

  Fly   972 ISNFGRSVSQQEDEEAEMAARGDFSVQSAQLQATKERLSIQESRVKHLTALLAENEQDLAKLTQM 1036
            |.:           |.||       ||....:..|::..:|        |.::|.:.::..|.|.
Mouse  1324 IKS-----------ELEM-------VQEDLSETQKDKFMLQ--------AKVSELKNNMKTLLQQ 1362

  Fly  1037 NDMLKEELRRQERSEEREQHMHNS-------------------------------EYLKNVFLKF 1070
            |..||.:|||....::..:...||                               |.|||
Mouse  1363 NQQLKLDLRRGAAKKKEPKGESNSSSPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKN----- 1422

  Fly  1071 LTLNNVDERQRLVPVLNTILRLSRNEMEMLNCVAKGQKVSADGSSRSW 1118
                           ||..|:..:.||:.|....:...::...|..||
Mouse  1423 ---------------LNNCLQQLKQEMDSLQRQMEEHTITVHESLSSW 1455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	201/888 (23%)
		TMPIT	458..>548	CDD:285135	29/96 (30%)
		GRIP	1058..1100	CDD:279767	11/72 (15%)
Golga3	NP_001334318.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118
		Interaction with GOPC. /evidence=ECO:0000250	121..141
		Golgi-targeting domain. /evidence=ECO:0000250	172..257
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..321
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..394		6/28 (21%)
		SMC_prok_A	<431..771	CDD:274009	85/400 (21%)
		Smc	622..1357	CDD:224117	182/827 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	785..804		9/18 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1372..1396		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1487
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839831
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930