Protein Alignment GCC185 and CEP164

DIOPT Version :10

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: XP_011540976.1
• Gene: CEP164 / 22897
• HGNCID: 29182
• Length: 2042
• Species: Homo sapiens
• Alignment Length: 1143
• Identity: 250/1143 - (21%)
• Similarity: 449/1143 - (39%)
• Gaps: 297/1143 - (25%)

  Fly     2 EAASPRETQKNPNPIEALS--KDEIISKYKGLLNIAKKAKQAKDELTEENHRLKDALKR-----A 59
            :||.|      |.|.:..|  .|..:|...|.......|:....| .|||.:.:..:.|     .
Human   836 DAAGP------PTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPE-KEENEKSEPKICRNLVTPK 893

  Fly    60 AEKQSSLPAM---QEMVQDFTDKNLILTEEVNNLKRKTKE-----------DADRLTQFEIENES 110
            |:...|.||.   :|..:|..|..    ||.:..:...||           .:|...:.||....
Human   894 ADPTGSEPAKASEKEAPEDTVDAG----EEGSRREEAAKEPKKKASALEEGSSDASQELEISEHM 954

  Fly   111 LKRQLGRLSDENDALLANVDRMEKAMQQVNALGNEQRKNLELLEVDIAKIKEAEAENASLRQQVA 175
            .:.||      :|::.::    .|:...:: .|...|.:..||:||:.    :.....:.||...
Human   955 KEPQL------SDSIASD----PKSFHGLD-FGFRSRISEHLLDVDVL----SPVLGGACRQAQQ 1004

  Fly   176 TMEEESSVLQQKYQNIKELNSEQRKKFNSLKDRFIDVHRKLKNLKECKCVLLETQ---------- 230
            .:..|.....|..|:  ||.|:|.                 |.|:|.....|:.:
Human  1005 PLGIEDKDDSQSSQD--ELQSKQS-----------------KGLEESSLPALQMEGPDSAALPGL 1050

  Fly   231 --------HEYAASVSKWQVEIIKASQLLCAKMASLQAENEKLKLNNG-----KSDNNPQTIDTG 282
                    ||..|.                :...||..|.|..:...|     :::...:.....
Human  1051 TRLSPPLPHEERAQ----------------SPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAAS 1099

  Fly   283 IDRKRLLQRVQEMDRLAKIVKQKQKNQRSNLNVEYLLKKITALEELAVIIKQQHRIDKEQLIS-- 345
            :..:..|||.|.....|...|.|:::.::              |||..  .|:...|.|:.::
Human  1100 LSLQLSLQREQAPSPPAACEKGKEQHSQA--------------EELGP--GQEEAEDPEEKVAVS 1148

  Fly   346 ----VTKEQENTKNHARNLNVSLFQTKLDQMQNLV-KVIAKER----DNQQRKLQEL-EAICIEL 400
                |:.|..:|:..|....:|  :..|..|:..| :|:.:::    :::|.|:|:| |.:|
Human  1149 PTPPVSPEVRSTEPVAPPEQLS--EAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLC--- 1208

  Fly   401 RQHNEDLLTRYHLKEQEHGELLTEMRELNEALKGRGDAISRLQEQHEAEVKRQRDLEAQLSNSQQ 465
            ::..|::|..:..|||.    |:.:||             |||:..|.|..|.|
Human  1209 QEEEEEILRLHQQKEQS----LSSLRE-------------RLQKAIEEEEARMR----------- 1245

  Fly   466 AAQEKLQKIKQLQSRVEELEQANADAQSDVLSTSTISRAEELSRLRELDEGYEEKYHKLRAIAAK 530
              :|:.|::..|:::|:...||:.|.          .|||:.:.|::|.|..|.:....||
Human  1246 --EEESQRLSWLRAQVQSSTQADEDQ----------IRAEQEASLQKLREELESQQKAERA---- 1294

  Fly   531 LKKKLQEQTQQLNEMEQSGALKEELEAIKLAQAQLQQDLNAARAEN-QKLKSK-EKVKHSSVLNL 593
               .|:::.:|:  :||   ||||:||.:.::   |..||||:.:. |:|:.: |..:..:|..|
Human  1295 ---SLEQKNRQM--LEQ---LKEEIEASEKSE---QAALNAAKEKALQQLREQLEGERKEAVATL 1348

  Fly   594 EIEAAEKSLSEVSAKLTAKSSELEAVKESLASKENTIV-QLRKEIAILEEAKNGEAAHSLELKEQ 657
            |.|               .|:|||.:..||.:|...:| .|:|:|   :||:..|.|       |
Human  1349 EKE---------------HSAELERLCSSLEAKHREVVSSLQKKI---QEAQQKEEA-------Q 1388

  Fly   658 IDRMQVQVKDAVHSKQ----------QALTQNK------DLEHGVEQAKLEAEQLRLQLSESAQQ 706
            :.:...||:..||.|.          .:|.:.|      :.|..:::.|.|.:|:   ::::.:|
Human  1389 LQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQV---MAKAREQ 1450

  Fly   707 YESKLNTATQQLLSQ-TQELE-MHLAEQKRLETALRNAERALEDLRVEYTEYKLKAQSV-----L 764
            ||::......:||.. |.||| :..|.::.|||..:...:.|||||..:.|.:.|.|.:     .
Human  1451 YEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLET 1515

  Fly   765 RKNQNKGSNREQELEEELVALRESERNLRASNDG--RAARLAQLDSQIEELRQDNTDLQKRSKEL 827
            |....|......|::|| .|.||.::.|......  ::........|:||.::::|.|.:.:::|
Human  1516 RAKDVKARLALLEVQEE-TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQL 1579

  Fly   828 VSLVDELRQQNDLLSLENQRQLQFQHDLMQQHRQQVDELDAGHQLQLTQVQEQLEEAQKMQANVS 892
            ..::|||:.:.  |.||:      |.||:|...||:.:..:..:.:..:.|..|.|....:.|.|
Human  1580 REILDELQARK--LKLES------QVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNAS 1636

  Fly   893 QHTTASAASVDTSPEQAKIDYLLMDHETGLDGHAGDVSLAQLAAQRK-ISTASRRSHDFMPLDEL 956
            .|...                         |.|..|:..:....|.| :|::..:|.:.:.||.|
Human  1637 PHFEP-------------------------DLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSL 1676

  Fly   957 LNTSMNQITSDTVTTISNFGRSVSQQEDEEAEMAARGDFSVQSAQLQATKERLSIQESRVKHLTA 1021
            .:.::..:.|.....:    ||..:...::.....|...::::||.....|..|.||
Human  1677 SSHNVWHLLSAEGVAL----RSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQE-------- 1729

  Fly  1022 LLAENEQDLAKLTQMNDMLKEELRRQERSEEREQHMHN 1059
             :|::...:..|..|...|::|.|..:..:...:..||
Human  1730 -VAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHN 1766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	PRK03918	<33..559	CDD:235175	120/579 (21%)
		Smc	<357..>920	CDD:440809	146/596 (24%)
		Grip	1057..1103	CDD:197860	2/3 (67%)
CEP164	XP_011540976.1	WW	59..89	CDD:238122
		PHA03307	823..>1190	CDD:223039	82/432 (19%)
		Smc	<1167..>1652	CDD:440809	148/606 (24%)