Protein Alignment GCC185 and Cep164

DIOPT Version :10

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: XP_006510196.1
• Gene: Cep164 / 214552
• MGIID: 2384878
• Length: 2034
• Species: Mus musculus
• Alignment Length: 1327
• Identity: 268/1327 - (20%)
• Similarity: 517/1327 - (38%)
• Gaps: 354/1327 - (26%)

  Fly    29 KGLLNIAKKAKQA------KDELTEENHRLKDALKRAAEKQSSLPAMQEMVQDFTDKNLILT--- 84
            ||||....:.|.|      .:|..||:....|        ..|:.:..|::     |||.|.
Mouse   750 KGLLASVHEGKNALSLLTLGEETNEEDEEESD--------NQSVRSSSELL-----KNLHLDLGA 801

  Fly    85 -------EEVNNLKRKTKE------DADR--------------------------------LTQF 104
                   ||.....:..|:      ||||                                ..|.
Mouse   802 LGGNFEYEESPRTSQPDKKDVSLDSDADRPPTPGKLFSQGADSSVASANGSKSQGRGASPWNPQK 866

  Fly   105 EIENESLKRQLGRLSDENDALLANVDRMEKAMQQVNALGNEQRKNLELLEVDIAKIKEAEAENAS 169
            |.||...|....:::.|.|.......|..|..|..:.:  :..|..|......||    |.:.||
Mouse   867 ENENSDPKASSSQMAPELDPGGDQPSRASKKQQAEDPV--QAGKEGECRRESAAK----EPKEAS 925

  Fly   170 LRQQVATMEEESSVLQQKYQNIKELNSEQR--KKF--------NSLKDRFID----------VHR 214
            ..:..:.:.|||.: ....::.:...||..  |.|        :.:.:..:|          .|.
Mouse   926 ALENTSDVSEESEI-HGHLKDARHSGSEASGPKSFLGLDLGFRSRISEHLLDGDTLSPVLGGGHW 989

  Fly   215 KLKNLKECKCVLLETQHEYAASVSKWQVEIIKASQLLCAKMASLQAENEKLKLNNGKSDNNP-QT 278
            :.:.|.:      |.|.:..:|:::.|.:..:.|          :.|:.:..|::..::..| ||
Mouse   990 EAQGLDQ------EEQDDSKSSIAEPQSKHTQGS----------EREHLQSSLHSQATEEGPLQT 1038

  Fly   279 IDTGIDRKR----------------LLQRVQEMDRLAKIVKQKQKNQRSNLNVEYLLKKITALEE 327
            ::...:.|.                ||||.|.:...|...:.::|:.::              ||
Mouse  1039 LEGQPEWKEAEGPGKDSVASPAPLSLLQREQVLSPPASPERAEEKHSQA--------------EE 1089

  Fly   328 LAVIIKQQHRIDKEQLIS------VTKEQENTKNHARNLNVSLFQTKLDQMQNLVKVIAKERDNQ 386
            |.  ::|....:.|:.::      |:.|.:..:..|..   .||.      :.::|.:..|.|
Mouse  1090 LG--LEQPEAEETEEKVAVCPSSPVSPEVQTAEPAAPQ---KLFS------EAILKGMELEED-- 1141

  Fly   387 QRKLQELEAICIELRQHNEDLLTRYHLKEQEHGELLTEMRELNEALKGRGDAISRLQEQHEAEVK 451
            ||.|.|.:.   |..|..|:.|.|.. :|:|.||  .|.:|..|            :|..|.|.:
Mouse  1142 QRLLLEFQK---EKPQQLEERLWREE-EEKEEGE--EEEKEDEE------------EEGEEEEEE 1188

  Fly   452 RQRDLEAQLSNSQQAAQEKLQKIKQLQSRVEELEQANADAQSDVLSTSTISRAEELSRLRELDEG 516
            .:::.|.:....::..|...||.|.|.....:|::|.|:.:          ..||.:::|
Mouse  1189 EEKEEEEEEEEEEEVCQLYQQKEKSLSLLKAQLQKATAEEK----------EKEEETKIR----- 1238

  Fly   517 YEEKYHKLRAIAAKLKKKLQEQTQQLNEMEQSG--ALKEELEAIKLAQ------------AQLQQ 567
             ||:..:|..:.|:::.:.:....|:...:|:.  .|:||.|.::.|:            .||::
Mouse  1239 -EEESRRLVCLRAQVQSRTEAFENQIRTEQQAALQRLREEAETLQKAERASLEQKSRRALEQLRE 1302

  Fly   568 DLNA-ARAENQKLKS-KEKVKHSSVLNLEIEAAEKSLSEVSAKLTAK-SSELEAVKESLASKENT 629
            .|.| .|:....|:: ||..|.:::|.|. |..|....|..|.|..| |:|||.:..||.:|...
Mouse  1303 QLEAEERSAQAALRAEKEAEKEAALLQLR-EQLEGERKEAVAGLEKKHSAELEQLCSSLEAKHQE 1366

  Fly   630 IV-QLRKEIAILEEAKNGEAAHSLELKEQIDRMQVQVKDAVHSKQQALTQNK----DLEHGVEQA 689
            :: .|:|:|...::.:..:...||...||....:|........:..:|.::|    :.||..:..
Mouse  1367 VISSLQKKIEGAQQKEEAQLQESLGWAEQRAHQKVHQVTEYEQELSSLLRDKRQEVEREHERKMD 1431

  Fly   690 KLEAEQLRLQLSESAQQYESKLNTATQQLLSQ-TQELE-MHLAEQKRLETALRNAERALEDLRVE 752
            |::.|..: :::::.::||::.......||.. |.||| :..|.::.||:..:..::.|||||..
Mouse  1432 KMKEEHWQ-EMADARERYEAEERKQRADLLGHLTGELERLRRAHERELESMRQEQDQQLEDLRRR 1495

  Fly   753 YTEYKLKAQSVLRKNQNKGSNREQELEEELVALRESERNLRASN----DGRAARLAQLDSQ---- 809
            :.:::.|.|.:    :.:.|:|.::::..|..|...|.|:|...    |  |.|.|.|:.:
Mouse  1496 HRDHERKLQDL----EVELSSRTKDVKARLAQLNVQEENIRKEKQLLLD--AQRQAALEREEATA 1554

  Fly   810 ----IEELRQDNTDLQKRSKELVSLVDELR-------QQNDLLSLENQR----------QLQFQH 853
                :||.::::|.|.:..::|...:|:||       .|.|||..::||          ::|.:.
Mouse  1555 THQHLEEAKKEHTHLLETKQQLRRTIDDLRVRRVELESQVDLLQAQSQRLQKHLSSLEAEVQRKQ 1619

  Fly   854 DLMQQHRQQVDELDAGHQ----LQLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPEQAKIDYL 914
            |::   ::...|::|...    |.:..:::.|:..:..:  ||...:.|...:|.|.|..:   .
Mouse  1620 DVL---KEMAAEMNASPHPEPGLHIEDLRKSLDTNKNQE--VSSSLSLSKEEIDLSMESVR---Q 1676

  Fly   915 LMDHETGLDGHAGDVSLAQLAAQRKISTASRRS-----HDF---------MPLDELLNT---SMN 962
            .:..|.....:|.:..:.|..:.|:..||.:.:     |:.         :|..|:|..   ::|
Mouse  1677 FLSAEGVAVRNAKEFLVRQTRSMRRRQTALKAAQQHWRHELASAQEVDEDLPGTEVLGNMRKNLN 1741

  Fly   963 QITS--DTVTTISNFGRSVSQQEDEEAEMAARGDFSVQSAQLQATKERLSIQESRVKHLTALLAE 1025
            :.|.  |.:.:....|..:.::::|:.       ..::|:..:...:..:::.|.:|.:|
Mouse  1742 EETRHLDEMKSAMRKGHDLLKKKEEKL-------IQLESSLQEEVSDEDTLKGSSIKKVT----- 1794

  Fly  1026 NEQDLAKLTQMNDMLKEELRRQ---------ERSEEREQHMHNSEYLK-----NVFLKFL-TLNN 1075
                 ..|:.|:|:..|.|...         ..::..:.|..:|...:     |..|..| :||:
Mouse  1795 -----FDLSDMDDLSSESLESSPVLHITPTPTSADPNKIHYLSSSLQRISSELNGVLNVLGSLNS 1854

  Fly  1076 VDERQRL-----VPVLNTILRLSRN----------EMEMLNCV-----------AKGQKVSADGS 1114
            ....|.|     .|:..:.||.|:|          ::..|:.:           .:|.|:::..|
Mouse  1855 QPPPQGLGSQPPPPLFTSSLRSSKNVLDPAYSSQAKLSSLSSITPMSTQWAWDPGQGTKLTSSSS 1919

  Fly  1115 SRSWTGF-LTAW-----SG----GGSP 1131
            |::...| |..|     ||    .|||
Mouse  1920 SQTVDDFLLEKWRKYFPSGIPLLSGSP 1946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	PRK03918	<33..559	CDD:235175	118/624 (19%)
		Smc	<357..>920	CDD:440809	142/619 (23%)
		Grip	1057..1103	CDD:197860	14/66 (21%)
Cep164	XP_006510196.1	WW	58..87	CDD:459800
		PHA03247	<325..740	CDD:223021
		Smc	1263..>1619	CDD:440809	89/363 (25%)
		EnvC	1541..>1789	CDD:443969	46/262 (18%)