DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCC185 and Ranbp2

DIOPT Version :9

Sequence 1:	NP_001097755.1	Gene:	GCC185 / 41459	FlyBaseID:	FBgn0037979	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	NP_035370.2	Gene:	Ranbp2 / 19386	MGIID:	894323	Length:	3053	Species:	Mus musculus

Alignment Length:	1165	Identity:	203/1165 - (17%)
Similarity:	392/1165 - (33%)	Gaps:	363/1165 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QKNPNPIEALS--KDEIISKYKGLLNIAKKAKQAKD-ELTEENHRLKDALKRAAEKQSSLPAMQE 71
            :|:|| .:..|  .:::.|...|  .:|:||..:.| |..::.::.:|:.....|....:|...|
Mouse  1800 KKDPN-FKGFSGAGEKLFSSQSG--KVAEKANTSSDLEKDDDAYKTEDSDDIHFEPVVQMPEKVE 1861

  Fly    72 MVQDFTDKNLILTEEVNNLKRKTKEDADRLTQFEIENESLKRQLGRLSDENDALLANVDRMEKAM 136
            :|....|:.::.::.|            :|.:|:.|....|                    |:.:
Mouse  1862 LVTGEEDEKVLYSQRV------------KLFRFDAEISQWK--------------------ERGL 1894

  Fly   137 QQVNALGNEQRKNLELLEVDIAKIKEAEAENASLRQQVATMEEESSVLQQKYQNIKELNSEQRKK 201
            ..:..|.||....|.:|      ::..:.........:.|.           .|:|.|:...| .
Mouse  1895 GNLKILKNEVNGKLRML------MRREQVLKVCANHWITTT-----------MNLKPLSGSDR-A 1941

  Fly   202 FNSLKDRFIDVHRKLKNL-----------------KECKCVL----LETQHEYAASVSKWQVEII 245
            :..|...|.|...||:.|                 :||:.:|    |:|.|:.        |:..
Mouse  1942 WMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKL--------VDTG 1998

  Fly   246 KASQLL--CAKMASLQAE------NEKLKL----NNGKSDNNPQTIDTGIDRKRLLQRVQEMDRL 298
            :|::|:  ..:|.|...:      |:::|:    |.....:.|...||
Mouse  1999 RAAKLIQRAEEMKSGLKDFKTFLTNDQVKVTDEENASSGADAPSASDT----------------- 2046

  Fly   299 AKIVKQKQKNQRSNLNVEYLLKKITALEE-------------LAVIIKQQHRIDKEQL---ISVT 347
              ..||...|....|..:....:..||::             .:.:.|...|..:...   .|..
Mouse  2047 --TAKQNPDNTGPALEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFK 2109

  Fly   348 KEQENTKNHARNLNVSLFQTKLDQMQNLVKVIAKERDNQQRK----LQELEAICIELRQHNEDLL 408
            .....:|:.|: ||.|......|:..::.:  .:|||.|..:    |.:|  :.:...:.||.::
Mouse  2110 SALSPSKSPAK-LNQSGASVGTDEESDVTQ--EEERDGQYFEPVVPLPDL--VEVSSGEENEQVV 2169

  Fly   409 TRYHLKEQEHGELLTEMRELNEALKGRGDAISRLQEQHEAEVK--RQRDLEAQL-SNSQQAAQEK 470
            ..:..|...:.:.:.:.:|     :|.|| |..||.....:|:  .:||...:| :|.:......
Mouse  2170 FSHRAKLYRYDKDVGQWKE-----RGIGD-IKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMT 2228

  Fly   471 LQKIKQL--------------QSRVEEL-----------------EQANADAQSDVLSTSTISR- 503
            ||.:|..              :.::|.|                 ::|....:.|.|.|..:|.
Mouse  2229 LQTMKGTERVWVWTACDFADGERKIEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSHL 2293

  Fly   504 ---------------AEELSRLR-ELDEGYE-------------------------EKY----HK 523
                           .||.:|.| :|.:|.|                         .|:    ..
Mouse  2294 STPRESPCGKIAIAVLEETTRERTDLTQGDEVIDTTSEAGETSSTSETTPKAVVSPPKFVFGSES 2358

  Fly   524 LRAIAAKLKKK---------------------LQEQTQQLNEMEQSGALKEELEAIKLAQAQLQQ 567
            :::|.:..|.|                     |:....::....|||:..:    :|..:.:|.|
Mouse  2359 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKNSNSEMTSRVQSGSEGK----VKPDKCELPQ 2419

  Fly   568 DLNAARAENQKLK-----SKEKVKHSSVLNLEIEAAEKSLSE---------VSAKLTAKSSELEA 618
            :.:..::.:.|:|     |||....|.......:|.|||..|         :..:|| .:.|.:|
Mouse  2420 NSDIKQSSDGKVKNLSAFSKENSSTSYTFKTPEKAQEKSKPEDLPSDNDILIVYELT-PTPEQKA 2483

  Fly   619 VKESLASKENTIVQLRKEIAILEEAKNGE----AAHSLELKEQIDRMQVQVKD--AVHSKQQALT 677
            :.|.|...........:...:.||.::.|    |...|..|..:|..:..:::  |.:.|:..:.
Mouse  2484 LAEKLLLPSTFFCYKNRPGYVSEEEEDDEDYEMAVKKLNGKLYLDDSEKPLEENLADNDKECVIV 2548

  Fly   678 QNKDLEHGVEQAKLEAEQLRL-------------QLSESAQQYESKLNTATQQLLSQTQELEMHL 729
            ..|  :..||: :.:|:.|:|             :.:.:.:.::|:|....:...||.:::...:
Mouse  2549 WEK--KPTVEE-RAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELRKVCEAQKSQNEKVTDRV 2610

  Fly   730 AEQKRLETALRN-----AERALEDLR--------------VEYTEYKLKAQSVLRKNQNK----- 770
            ..:...||.:.|     :|....|.:              |:.:..|........|.:||
Mouse  2611 GIEHIGETEVTNPVGCKSEEPDSDTKHSSSSPVSGTMDKPVDLSTRKETDMEFPSKGENKPVLFG 2675

  Fly   771 -GSNREQELEEEL------VALRESERNLRASNDGRAARLAQLDSQIEELRQDNTDLQKRSKE-- 826
             ||.......:..      .|....::|.:.:|.|.|....|..|:..| .:|.:|......|
Mouse  2676 FGSGTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQTTSKGGE-DEDGSDEDVVHNEDI 2739

  Fly   827 ----LVSL----VDELRQQNDLLSLENQRQLQFQHDLMQ-----------------------QHR 860
                :|||    |....:..::|..|..:..::..|:.|                       ..|
Mouse  2740 HFEPIVSLPEVEVKSGEEDEEVLFKERAKLYRWDRDVSQWKERGIGDIKILWHTMKKYYRILMRR 2804

  Fly   861 QQVDELDAGHQLQLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPEQAKIDYLLMDHET 920
            .||.::.|.|.:......:.|        |||.:.....|| |.:..:||::.|.:..:|
Mouse  2805 DQVFKVCANHVITKAMELKPL--------NVSNNALVWTAS-DYADGEAKVEQLAVRFKT 2855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	169/996 (17%)
		TMPIT	458..>548	CDD:285135	24/188 (13%)
		GRIP	1058..1100	CDD:279767
Ranbp2	NP_035370.2	TPR 1	26..59
		TPR_11	59..126	CDD:290150
		TPR repeat	59..89	CDD:276809
		TPR 2	60..93
		TPR_1	60..92	CDD:278916
		TPR 3	94..128
		TPR 4	165..201
		TPR 5	288..319
		TPR 6	583..616
		TPR 7	648..681
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	773..802
		RCR	<839..925	CDD:304939
		20 X 2 AA repeats of F-G. /evidence=ECO:0000305	1000..3035		203/1165 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1171
		RanBD1_RanBP2-like	1180..1296	CDD:270203
		zf-RanBP	1345..1374	CDD:279035
		RanBP2-type Zn finger	1350..1369	CDD:275375
		zf-RanBP	1410..1438	CDD:279035
		RanBP2-type Zn finger	1414..1433	CDD:275375
		zf-RanBP	1469..1498	CDD:279035
		RanBP2-type Zn finger	1473..1492	CDD:275375
		zf-RanBP	1499..1524	CDD:279035
		RanBP2-type Zn finger	1502..1521	CDD:275375
		zf-RanBP	1558..1587	CDD:279035
		RanBP2-type Zn finger	1562..1581	CDD:275375
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1587..1609
		zf-RanBP	1617..1645	CDD:279035
		RanBP2-type Zn finger	1621..1640	CDD:275375
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1648..1675
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1772
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1819..1846		7/28 (25%)
		RanBD2_RanBP2-like	1864..1980	CDD:269998	24/165 (15%)
		Interaction with BICD2. /evidence=ECO:0000250\|UniProtKB:P49792	1984..2124		27/167 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2030..2060		7/48 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2111..2144		8/35 (23%)
		RanBD3_RanBP2-like	2161..2277	CDD:270204	20/121 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2316..2348		4/31 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2394..2430		6/39 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2443..2463		6/19 (32%)
		IR1-M	2468..2529	CDD:288995	12/61 (20%)
		Interaction with sumoylated RANGAP1. /evidence=ECO:0000250	2468..2472		0/3 (0%)
		2 X 50 AA approximate repeats	2470..2596		23/129 (18%)
		Required for E3 SUMO-ligase activity. /evidence=ECO:0000250	2470..2545		15/75 (20%)
		Interaction with UBE2I. /evidence=ECO:0000250	2470..2522		10/52 (19%)
		Interaction with SUMO1. /evidence=ECO:0000250	2523..2596		12/75 (16%)
		IR1-M	2544..2602	CDD:288995	8/60 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2598..2666		9/67 (13%)
		RanBD4_RanBP2-like	2754..2870	CDD:269999	20/111 (18%)
		cyclophilin_ABH_like	2893..3051	CDD:238907
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900