Protein Alignment GCC185 and gcc-2

DIOPT Version :10

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: NP_001022748.1
• Gene: gcc-2 / 176378
• WormBaseID: WBGene00011503
• Length: 660
• Species: Caenorhabditis elegans
• Alignment Length: 765
• Identity: 175/765 - (22%)
• Similarity: 313/765 - (40%)
• Gaps: 191/765 - (24%)

  Fly   434 GRGDAISRLQEQHEAE-VKRQRDLEAQLSNSQQAAQEKLQKIKQLQSRVEELEQANADAQSDVLS 497
            |.|..:..|.::...: .|:|....|::..:|.|..||      |::::.||||...||::
 Worm    19 GGGKKLDSLPKEDLVKFAKKQVAHVAEMKKNQTALMEK------LKAKMSELEQVKKDAEN---- 73

  Fly   498 TSTISRAEELSRLRELDEGYEEKYHKLRAIAAKLKKKLQEQTQQLNE-MEQSGALKEELEAIKLA 561
                        |:.::|       ||...:|   ||::....:..| :.:||||.|
 Worm    74 ------------LKLINE-------KLTTESA---KKVENNPTECTECLSKSGALIE-------- 108

  Fly   562 QAQLQQDLNAARAENQKLKSKEKVKHSSVLNLEIEAAEKSLSEVSAKLTAKSSELEAVKESLASK 626
                        .|.:..:.|||...:.:::||:...|..:.:::..|..|:..|...:|.:...
 Worm   109 ------------LEKEVFEWKEKATRADMISLELRDLESKVDQLNRALRDKTEALIKAQEVITEN 161

  Fly   627 ENTIVQLRKEIAILEEAKNGEAAHSLELKEQIDRMQVQVKDAVHSKQQALTQNKDLEHGVEQAKL 691
            :..:..::||       ||...:...:|.|:..|:           .:|| |::.::....:|:|
 Worm   162 DLEVNNMKKE-------KNNTKSSIEKLTEENTRL-----------TKAL-QDEKIKSADFEARL 207

  Fly   692 EAEQLRL-QLSESAQQYESKLNTATQQLLSQTQ-------------ELEMHLAEQKRLETALRNA 742
            .:.:.|: :||:  ||...||..|.:...|:.:             |.|..||:.:.....|.::
 Worm   208 RSAECRIVELSD--QQGNEKLGLARKMAESENRGRILEEAVDVLKSENEKLLAKNEEFSAKLVSS 270

  Fly   743 ERALEDLRVEYTEYKLKAQSVLRKNQNKGSNREQELEEELVALRESERNLRASNDGRAARLAQLD 807
            |:       |:.|:|.|:..||.|   || .:|.|..:.:..|.:|:           ..:.:|:
 Worm   271 EK-------EFAEFKKKSHFVLEK---KG-KQEDETRKAIEKLEKSK-----------VTITELE 313

  Fly   808 SQIEELRQDNTDLQKRSKELVSLVDELRQQNDLLSLENQRQLQFQHDLMQQHRQQVDELDAGHQL 872
            .|.::.||::.   |..::|.|..|:..:....|.:......:.:    :.|...:|||.:....
 Worm   314 QQADQTRQEHF---KTVEDLASSRDKAERLEKTLKVLKSELTESE----KAHTTAIDELQSSSSK 371

  Fly   873 QLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPEQAKIDYLLMDHETGLDGHAGDVSLAQLAAQ 937
            .:.::.|:|...:      |...||.....|....:.|:|:||.:.....:...|.:       :
 Worm   372 LIQRLDEELRLMR------SSRDTAEQKIKDIEIAKEKVDHLLQNERQRSENENGSL-------K 423

  Fly   938 RKISTASRRSHDF-MPLDELLN------TSMNQ-------------------------------- 963
            .|:|:|:::.|.. ..|.||.|      ...||
 Worm   424 SKLSSATKQIHSLEKELQELRNDFETRRIQSNQHQQQKAIAAVVPQPIQLPEHPIPPLHYQRPAV 488

  Fly   964 ITSDTVTTISNFGRSVSQQEDEEAEMAARGD----FSVQSAQLQATKERLSI-QESRVK----HL 1019
            ..||:|:....     ..|.|...|....||    :.|:|.:|...|.::.: |...:|    |:
 Worm   489 APSDSVSCYDE-----PTQPDRSLEDVLYGDLGDEYRVESDELSEEKFKVILDQLENLKKTNHHV 548

  Fly  1020 TALLAENEQDLAKLTQMNDMLKEELRRQERSEEREQHMHNS---EYLKNVFLKFLTLNNVD-ERQ 1080
            ..||::.|....:||..|.:||:|:||.||.|:||..:.|.   |||||||::||...:|. ||.
 Worm   549 AELLSDAETANGRLTTQNSLLKDEIRRLEREEKREAELSNEKNMEYLKNVFVQFLKPESVPAERD 613

  Fly  1081 RLVPVLNTILRLSRNEMEMLNCVAKGQKVSADGSSRSWTGFLTAWSGGGS 1130
            :||.||..:|.||..|:|:|...:.....:..|   ||:.:.:.|||..:
 Worm   614 QLVIVLQRVLHLSPKEVEILKAASAHMATAQAG---SWSSYFSGWSGAAT 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	PRK03918	<33..559	CDD:235175	30/126 (24%)
		Smc	<357..>920	CDD:440809	104/501 (21%)
		Grip	1057..1103	CDD:197860	23/49 (47%)
gcc-2	NP_001022748.1	PRK05771	22..>212	CDD:235600	51/260 (20%)
		SMC_prok_B	<179..>464	CDD:274008	70/340 (21%)
		Grip	589..636	CDD:197860	22/46 (48%)