Protein Alignment GCC185 and Numa1

DIOPT Version :10

• Sequence 1: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: NP_001390473.1
• Gene: Numa1 / 101706
• MGIID: 2443665
• Length: 2108
• Species: Mus musculus
• Alignment Length: 353
• Identity: 79/353 - (22%)
• Similarity: 134/353 - (37%)
• Gaps: 71/353 - (20%)

  Fly    27 AKSQRNQFRQWLL-----TAVLPNSINDQRKEAFASLELTEQPQ-----QVEKVKKSEKKKAQKQ 81
            |..:|::.||.::     ||.:..|:..::.....|.|...|.|     :.:|:.:::|.:..:.
Mouse   513 ALEKRHKIRQMMIEEYNKTATMLKSVLQEQDGNILSKENVIQEQRGKLGEKDKMLQNQKNEIDRL 577

  Fly    82 IAKDHEAEQKVNAKKAA------EKEARRAEAEAKKRAAQEEEHKQWKAEQERIQKEQEKKEADL 140
            ..|....|.|::..:..      :|.:.:.|.|::::..|.|     .:|:.||:...:...:|
Mouse   578 EKKSKMLEYKIDILQKTTNIYEEDKRSLQNELESREQRLQRE-----MSEKRRIEARMQGMVSD- 636

  Fly   141 KKLQAEKKKEKAVKAEKAE-------KAEKTK---------KASTPAPVEEEIVVKKVANDRSAA 189
            .||:.||:.|:.|.|::.|       |.||.|         |.....|........||...|||:
Mouse   637 TKLKWEKECERRVNAKQLEMQNKLWVKDEKLKQLKAIVTEGKTENRQPQRPSREKDKVPPKRSAS 701

  Fly   190 PAPEPKTPTNTPAEPAEQVQEITGKKNKKNKKKSESEATAAPASVE-QVVEQPKVVTEEPHQQAA 253
            |:|   .||..|..|..:.....|.:...:.|.:        .:|: ..|.||
Mouse   702 PSP---APTGPPVRPLHRRSHSAGGERWVDHKPT--------TNVDLDTVMQP------------ 743

  Fly   254 PQEKKNKKNKRKSESENVPAASETPVEPVVENE-SPESEPVAKLI--TVSNTEASAVNVMGFSDI 315
                 |..|..|..:.|..|.|:.....:...| :.:.|...|||  .|..|.....:|. |:||
Mouse   744 -----NIPNAIKVNAPNEKALSKCDKYVLTHQEVASDGEIQTKLIKGEVFKTRGGGQSVQ-FTDI 802

  Fly   316 VTPKADEVITQDPVSAKQEVLPEHVPSE 343
            .|.|.:..:.........|..|:..|.|
Mouse   803 ETLKQETPVAASRKRRSSESGPDSEPME 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	PRK03918	<33..559	CDD:235175	77/347 (22%)
		Smc	<357..>920	CDD:440809
		Grip	1057..1103	CDD:197860
Numa1	NP_001390473.1	Head (Globular). /evidence=ECO:0000250|UniProtKB:Q14980	1..210
		HkD_NuMA	6..151	CDD:411795
		Smc	<213..>814	CDD:440809	75/335 (22%)
		SMC_prok_B	554..1323	CDD:274008	70/312 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	617..636		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	723..759		9/60 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	921..1000
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1081..1143
		Smc	<1117..>1652	CDD:440809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1173..1223
		PRK06975	<1566..1754	CDD:235899
		Membrane-binding domain 1. /evidence=ECO:0000250|UniProtKB:Q14980	1695..1872
		Tail (Globular). /evidence=ECO:0000250|UniProtKB:Q14980	1696..2108
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1732..1757
		Tankyrase-binding domain. /evidence=ECO:0000250|UniProtKB:Q14980	1738..1744
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1774..1809
		4.1-binding domain. /evidence=ECO:0000250|UniProtKB:Q14980	1784..1806
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1821..1897
		NuMA_LGNBD	1866..1924	CDD:412093
		Tubulin-binding domain. /evidence=ECO:0000250|UniProtKB:Q14980	1878..1981
		GPSM2-binding domain. /evidence=ECO:0000250|UniProtKB:Q14980	1888..1922
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1951..2108
		Membrane-binding domain 2. /evidence=ECO:0000250|UniProtKB:Q14980	1977..2056
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q14980	1980..1985