DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCC185 and numa1

DIOPT Version :9

Sequence 1:	NP_001097755.1	Gene:	GCC185 / 41459	FlyBaseID:	FBgn0037979	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	XP_031753275.1	Gene:	numa1 / 100145664	XenbaseID:	XB-GENE-6259084	Length:	2302	Species:	Xenopus tropicalis

Alignment Length:	1283	Identity:	292/1283 - (22%)
Similarity:	524/1283 - (40%)	Gaps:	316/1283 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DELTEENH----RLKDALKRAAEKQSSLPAMQEMVQDFTDKNLILTEEVNNLKRKTKEDADRLTQ 103
            :||.|:|.    ||:|.||:..:.::....::.       ||..|.||...|..|.::.::||.|
Frog   285 EELREKNESLMIRLRDTLKQCQDMKTDKKQLER-------KNDQLAEENGELSYKVRDLSNRLAQ 342

  Fly   104 FEIENESLKRQLGRLSDENDALLANVDRMEKAMQQ--VNALGNEQRKNLE-----------LLEV 155
                   |:..|...::|::..|:|.::.:..::.  ..|:|  ::|.||           :||.
Frog   343 -------LQEALYETTEEHELSLSNWEQKQSQLESELSGAVG--EKKYLEEHHLILQGKISMLED 398

  Fly   156 DIAKIKEAEAEN-------------------------ASLRQQVATMEEESSVLQQKYQNIKELN 195
            .:.|:.|.|.|.                         .||.:|:..:|||.|.        .|::
Frog   399 QLKKMGEREVEEKGDCMGDILKLEDLKQEVTALSTQCLSLTEQIHQLEEEKST--------TEID 455

  Fly   196 SE-QRKKFNSLKDRFIDVHRKLKN-------LKECKCVLLETQHEY-AASVSKWQVEIIKASQLL 251
            .| ||.:|.|.|.:..::...|:.       .||.:......|.|: ...::..::||.|....|
Frog   456 MEAQRSRFESEKSQLQEIVTNLQTSLSEITFQKERQDNEARAQQEHLTCQITTLKLEISKLKSSL 520

  Fly   252 CAKMASL-----QAENEK---------LKLNNGKSDNNPQTIDTGIDR---------KRLLQRVQ 293
            ..|...|     |.|.||         .|:....|..|.|.:...:::         ..|:...|
Frog   521 VHKEEELKGIHHQVEEEKREKNQLLENFKILEESSKQNIQELVNQVEQISSSLKVSEGNLVGLTQ 585

  Fly   294 EMDRLAKIVKQKQKNQR----------SNLNVEYLLKKITALEELAVI------IKQQHRIDKEQ 342
            :::..||.|...::.|:          |..| ||..||.   ||.:|:      ::|.|:.....
Frog   586 QLESKAKEVDYLREEQQKVACERDSTLSTFN-EYKCKKD---EEFSVLNMTMKTLEQDHQASLSV 646

  Fly   343 LISVTKEQENTKNHARNLNVSLFQTKLDQMQNL-----------------VKVIAKERDNQ---- 386
            :..:.:|:....:..:.|:.::... |.:.|||                 :|....|:::|
Frog   647 IEELKREKAELASKLQELDATILDL-LAKCQNLDSENASQSKSHAAAVESLKAQLSEQESQLKIY 710

  Fly   387 QRKLQELEAICIELRQHNEDLLTR----YHLKEQEHGELLTEMRELNEALKGRGDAISRLQEQHE 447
            |:|:...|.:..|..|..|.||:.    .||:|    .|..|..:...:|...|..||.|:|:.:
Frog   711 QKKVSSCELVSEENSQLKEQLLSMDESLRHLRE----HLEKEKMKFAASLDSDGKRISHLEEEMK 771

  Fly   448 AEVKRQRDLEAQLSN--SQQAAQEKLQ-KIKQLQSRVEELEQANADAQSDVLSTSTISRAEELSR 509
             ::...||  |.|||  .::||.:|:: ::|.||   ||...||...|:.:..:|...:..|..|
Frog   772 -KLSESRD--AALSNLAEERAAGQKIESQLKHLQ---EEYHTANETLQAKMAESSAAIKQREAER 830

  Fly   510 LRELDEGYEEKYHKLRAIAAKLKKKLQEQTQQLNEMEQSGALKEELEAIKLAQAQLQQDLNAARA 574
                ||        |..:....|.|.:|..|::  ::.|..::|:::.:|.|...:.|.|...::
Frog   831 ----DE--------LSKVVDIWKAKYEESQQKI--VQNSCQMEEQIQHLKKAHTDVCQQLEGEKS 881

  Fly   575 ENQKLKSKEKVKHSSVLNLEIEAAEKSLSEVSAKLTAKSSELEAVKESLASKENTIVQLRKEIAI 639
            :...|::|.|..:||.|. :|...|..|||..:::..:.:|.:.:..:|.|.|       ::..|
Frog   882 KVLMLEAKIKETNSSQLE-QINRLECELSEAYSRIKEREAEEKKLLSALHSSE-------EKFQI 938

  Fly   640 LEEAKNGEAAHSLE-----LKEQIDRMQVQVKDAVHSKQQALTQNKDL----------------- 682
            ..:.::...:| ||     .|.::|.:..:|.|..|.|::.....|:|
Frog   939 AHQGESERLSH-LETALSNAKSELDCLVREVSDEKHKKEELEALVKELKEQKSERIQSLESEVKT 1002

  Fly   683 ------EHGVEQAKL--EAEQLRLQLSESAQQYESKL---NTATQQLLSQTQELEMHLAE----- 731
                  |...|.|||  |.:.|..||.|..|:::.:|   ||..:||:...::..:.||.
Frog  1003 SLAAVKERESETAKLSEEVKDLNRQLEEIGQKHKEELAQKNTEIEQLIEAKEKAALDLASKTEMG 1067

  Fly   732 ---QKRLET------ALRN-AERALEDLRVEYTE----YKLKA--QSVLRKNQNKGSNREQELE- 779
               ||.|:|      ||:| ..|:|:.:..:.:|    :|..|  |..:||.|.......:||.
Frog  1068 AQLQKLLDTHKGELSALQNELSRSLDLISQKESEVERLHKEAAVTQEEIRKQQQTMGKLTEELTA 1132

  Fly   780 ----EELVALRESE--RNLRASNDGRAARLAQLDSQIEELRQD----NTDLQKRSKELVSLVDEL 834
                :|..||:|.|  :::||:. |..|.:|.|.:.|.|..::    ..|::.:..:|..:.::.
Frog  1133 LVALKEQAALQEKEIAQHVRATK-GAEAEMANLKAIISEKTKNIESLEHDIKNQKGDLACIQEQY 1196

  Fly   835 R-QQNDLLSLENQ-----RQLQFQHDLMQQHRQQVDELDAGHQLQLTQVQEQLEEAQKMQANV-- 891
            | :|.:...|:.|     |:.:.|.:|:.|.::|..|.:.....:::..:.|||..|.::..:
Frog  1197 RSKQEEARGLQGQIVDLERECKEQKELICQAQKQAAEAETLASEKVSTSERQLEGIQALEGEIHK 1261

  Fly   892 -SQHTTASAASVDTS-PEQAKIDYLLMDHETGLDGHAGDV--SLAQLAAQRKISTASRRSHDFMP 952
             .|.|......::.| ..||       |.||.|.....::  .:.:|...:|.||.|.|.
Frog  1262 ERQKTCDLLKQLEASQAAQA-------DKETELQALKKELFHKVQELEQSQKSSTESSRE----- 1314

  Fly   953 LDELLNTSMNQITSDTVTTISNFGRSVSQQEDEEAEMAARGDFSVQSAQLQATKERLSIQESRVK 1017
            |..:|:.:..:..:.|.      .:..::|..:|.||.::     :...|.|..:.||   |:|:
Frog  1315 LSSMLSAAQERQRALTE------AKQQAEQYQKEIEMKSK-----EVGSLHAEVKSLS---SKVE 1365

  Fly  1018 HLTALLAENEQDLAKLTQMNDMLKEELRRQERSEEREQHMHNSEYLKNVFLKFLTLNNVDERQRL 1082
                :.||.||.|.|.|..:..|:|:|::.....|..    :.|.|              |:.|.
Frog  1366 ----VSAEFEQRLLKETNRSTKLEEKLKKLHGDVEAS----SKELL--------------EKNRA 1408

  Fly  1083 VPVLNTILRLSRNEMEMLNCVAKG--QKVSADGSS--------RSWTG 1120
            :..|.|..:..|.|.:......:|  |.:|:...:        |||.|
Frog  1409 MDSLKTEAQTCRQEADKQRMAVEGLQQSLSSQAETNDRLQQEIRSWQG 1456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	221/948 (23%)
		TMPIT	458..>548	CDD:285135	25/92 (27%)
		GRIP	1058..1100	CDD:279767	8/41 (20%)
numa1	XP_031753275.1	HkD_SF	5..155	CDD:425405
		Smc	220..1063	CDD:224117	191/839 (23%)
		Smc	763..1629	CDD:224117	183/772 (24%)
		Smc	<1595..>1822	CDD:224117
		NuMA_LGNBD	2024..2075	CDD:412093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000