Protein Alignment KLHL18 and KLHL13

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001161771.1
• Gene: KLHL13 / 90293
• HGNCID: 22931
• Length: 658
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 175/572 - (30%)
• Similarity: 287/572 - (50%)
• Gaps: 43/572 - (7%)

  Fly    29 FKEIRRMGKLCDVTLKV--EDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSA 91
            |.::|..|.||||||..  .|..|..|||::|:...||.||||..|.|..:  :.:|...:....
Human    85 FDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL--MCIKLHGVSKVG 147

  Fly    92 LESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICR 156
            |..:|:::|:.::.::..|:|:.:..|||||:..|.|.|..||||.....|.:.:...|::....
Human   148 LRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLT 212

  Fly   157 QLIDAADKYID----QNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAED 217
            ::    |||::    :||..:..:.|||.|..|:|..::..:.|...||..:|:|..:|:: .|:
Human   213 EV----DKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR-LEE 272

  Fly   218 KRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTR 282
            .|.:...:::..:|.||::||.|.:.|...:.:|:.:.|.:||.||.::.:||..:.::||.||.
Human   273 PRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTA 337

  Fly   283 QRSGEFFTGQIYAVGGLASTGESVS-TVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGG 346
            .||.   |..:..:||:......|| .:.:||....:||....|...|.:.|:||:...||..||
Human   338 IRSD---TTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGG 399

  Fly   347 -----FNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVY 406
                 ..|...:.||..:|||.|||.|..::..||:...::||...:|..||.:....|.|||.|
Human   400 QSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECY 464

  Fly   407 YPKSNTWKTVAQMMK--YRSAGGVTQLNGYVYALGG--HDGLSIFDSVERYDQAEDVWVKMSPML 467
            .|::|.|..||:|.:  |..||  |...|.:|..||  ||  :....:..:|...|.|::.:||.
Human   465 NPRTNEWTYVAKMSEPHYGHAG--TVYGGVMYISGGITHD--TFQKELMCFDPDTDKWIQKAPMT 525

  Fly   468 NRRCRLGVATLNGKIYVCGGYCGNSF--------LRSVECYDPQTDTWKLVTPMNCKRSRVALAA 524
            ..|....:.|:..::||.|   ||.|        :.|.|.|.|..|.|..:..|...:|.|.:|.
Human   526 TVRGLHCMCTVGERLYVIG---GNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAV 587

  Fly   525 NMGKLWAIGGYDGESN--LSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRI 574
            ...|::.:|||...:.  :..|:.|||:.|:|..:..:....||:.|..:.:
Human   588 FENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTV 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	40/109 (37%)
		PHA03098	36..510	CDD:222983	156/497 (31%)
		KELCH repeat	329..372	CDD:276965	18/47 (38%)
		KELCH repeat	376..417	CDD:276965	14/40 (35%)
		KELCH repeat	423..466	CDD:276965	12/44 (27%)
		KELCH repeat	470..514	CDD:276965	14/51 (27%)
		Kelch_1	517..560	CDD:396078	13/44 (30%)
		KELCH repeat	517..560	CDD:276965	13/44 (30%)
KLHL13	NP_001161771.1	BTB_POZ_KLHL9_13	72..199	CDD:349548	41/115 (36%)
		PHA03098	95..638	CDD:222983	171/559 (31%)
		KELCH repeat	382..430	CDD:276965	18/47 (38%)
		KELCH repeat	434..478	CDD:276965	16/43 (37%)
		KELCH repeat	481..526	CDD:276965	15/48 (31%)
		KELCH repeat	528..577	CDD:276965	14/51 (27%)
		KELCH repeat	580..627	CDD:276965	13/46 (28%)