DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and KBTBD6

DIOPT Version :10

Sequence 1:NP_650143.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_690867.3 Gene:KBTBD6 / 89890 HGNCID:25340 Length:674 Species:Homo sapiens


Alignment Length:603 Identity:159/603 - (26%)
Similarity:239/603 - (39%) Gaps:155/603 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 LCDVTLKV--------EDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALES 94
            |||||::|        ..:.|..:|.||||..|||.:|||..|.||:...:||.:  ::..:.|.
Human    62 LCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHD--VDAESFEV 124

  Fly    95 LINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLI 159
            |::|.|:|:|.:...||:.|...:..|||..||:||||||..|....|...|..|||:...|:|.
Human   125 LVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFGHRKLR 189

  Fly   160 DAADKYIDQNFAKVSQ----SEEFLA-LDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKR 219
            ..|..||.|||.::|.    .||.|| |...|||.::|.|.|:|.:|:.:....::|::.|..:|
Human   190 SQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKER 254

  Fly   220 SELFPQVLAAVRLPLLSPQFLADRVAREELIRS---SHQCRDLLDEAKDFH--------LMPERR 273
            .....:|...||....:.:   |:...|.|:..   ...|.|:::.|....        |:|...
Human   255 GPSAAEVFKCVRWMHFTEE---DQDYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPN 316

  Fly   274 GLLQSFRTR----------QRSG--------------------EFFTGQIYAVGG----LASTGE 304
            ....|..:.          ||.|                    :.::|.:|.|..    ||.| .
Human   317 SSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHT-R 380

  Fly   305 SVSTV--------EIY---DPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEV 358
            :|:|:        :||   .|.|..|                                      |
Human   381 TVTTLAVCISPDHDIYLAAQPRTDLW--------------------------------------V 407

  Fly   359 YDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVT--SLNTVEVYYPKSNTWKTVAQMMK 421
            |.|.:|.|.|....|..|..:.||.|:..||:.||.|.:|  .|..||.|..|.|.|..||.:..
Human   408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPH 472

  Fly   422 YRSAGGVTQLNGYVYALGGHDGLSIFDSVER---YDQAEDVWVKMSPMLNRRCRLGVATLNGKIY 483
            ...:..:..:..|:|||..          :|   ||.:.::|:| ...|.|.........|.:||
Human   473 SFLSFDLMVIRDYLYALNS----------KRMFCYDPSHNMWLK-CVSLKRNDFQEACVFNEEIY 526

  Fly   484 -VCGGYCGNSFLRSVECYDPQTDTWK------LVTPMNCKR-----SRVALAANMGKLWAIGGYD 536
             :|.       :..::.|:|....|:      ||:..|..|     .::.|..:....|      
Human   527 CICD-------IPVMKVYNPVRAEWRQMNNIPLVSETNNYRIIKHGQKLLLITSRTPQW------ 578

  Fly   537 GESNLSTVEVYDPETDKW 554
             :.|..||..||...|:|
Human   579 -KKNRVTVYEYDIRGDQW 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_650143.1 BTB_POZ_KLHL18 20..137 CDD:349556 43/106 (41%)
PHA03098 36..510 CDD:222983 146/552 (26%)
KELCH repeat 329..372 CDD:276965 6/42 (14%)
KELCH repeat 376..417 CDD:276965 17/42 (40%)
KELCH repeat 423..466 CDD:276965 9/45 (20%)
KELCH repeat 470..514 CDD:276965 9/50 (18%)
Kelch_1 517..560 CDD:396078 10/43 (23%)
KELCH repeat 517..560 CDD:276965 10/43 (23%)
KBTBD6NP_690867.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
BTB_POZ_KBTBD6_7 37..178 CDD:349582 46/117 (39%)
PHA03098 55..553 CDD:222983 146/552 (26%)
BACK_KBTBD6_7 168..270 CDD:350557 33/101 (33%)
Kelch 1 386..435 16/86 (19%)
KELCH repeat 425..471 CDD:276965 19/45 (42%)
Kelch 2 436..484 15/47 (32%)
Kelch 3 486..523 10/47 (21%)
KELCH repeat 512..551 CDD:276965 8/45 (18%)
Kelch 4 524..564 10/46 (22%)
Kelch 5 567..616 9/36 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..674
ATG8 interaction motif (AIM). /evidence=ECO:0000269|PubMed:25684205 668..671
Blue background indicates that the domain is not in the aligned region.

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