Protein Alignment KLHL18 and ENC1

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_003624.1
• Gene: ENC1 / 8507
• HGNCID: 3345
• Length: 589
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 168/564 - (29%)
• Similarity: 262/564 - (46%)
• Gaps: 49/564 - (8%)

  Fly    18 HDKLFGESFPLFKEIRRMGKL-CDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEIT 81
            |...:.:|......:.|..:| .||.|...::||..||.||||...||.|||:..:.||:..|:.
Human    24 HKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVN 88

  Fly    82 MKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGI 146
            . :::|.|..||.|::|.||.:|.|:.:|.::|:.....|:..::|||||.||....||.|.||:
Human    89 F-DNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 152

  Fly   147 RTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKW 211
            ...:|:..|.:|.:.:.:....||..:.::|:||.|..:.:::|:..:||....|.:::|:.:.|
Human   153 LLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINW 217

  Fly   212 VKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHL-MPERRGL 275
            :.|...||....|::|..|||.||...:|.:.||.||||....:.:::::||....| :.:..|:
Human   218 ISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGV 282

  Fly   276 LQSFRTRQR---------SGE-FFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRS 330
            :.|...|.|         .|: |...::|.|...|.  |.:...:|..|              |.
Human   283 VTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAK--EIIPKADIPSP--------------RK 331

  Fly   331 RVGVAVLNGKLYAFGGFNGTER--LSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGG 393
            ......:..|:|..|| .|:|.  ...|.|||....:||:...||..|...|.|.|..|:||.||
Human   332 EFSACAIGCKVYITGG-RGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGG 395

  Fly   394 YDGVT---------SLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGG----HDGLS 445
            :...|         ||..||.|.|..|.|..||.:.:..|...|......::|.||    ||.|
Human   396 HTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKL- 459

  Fly   446 IFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLV 510
              ..|:.|||.|:.|...:...........|.|..:|::.||....|...:.: ::.:|..|..|
Human   460 --PKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAYK-FNSETYQWTKV 521

  Fly   511 TPMNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKW 554
            ..:..||......|:..||:.:|||.|.....|::.|||..|.|
Human   522 GDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVW 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	42/117 (36%)
		PHA03098	36..510	CDD:222983	149/500 (30%)
		KELCH repeat	329..372	CDD:276965	13/44 (30%)
		KELCH repeat	376..417	CDD:276965	18/49 (37%)
		KELCH repeat	423..466	CDD:276965	14/46 (30%)
		KELCH repeat	470..514	CDD:276965	9/43 (21%)
		Kelch_1	517..560	CDD:396078	14/38 (37%)
		KELCH repeat	517..560	CDD:276965	14/38 (37%)
ENC1	NP_003624.1	BTB_POZ_KLHL37_ENC1	6..152	CDD:349576	47/128 (37%)
		PHA03098	48..566	CDD:222983	163/540 (30%)
		BACK_KLHL37_ENC1	145..242	CDD:350590	29/96 (30%)
		Kelch 1	296..340		9/59 (15%)
		KELCH repeat	330..374	CDD:276965	13/44 (30%)
		Kelch 2	341..388		18/47 (38%)
		KELCH repeat	378..431	CDD:276965	20/52 (38%)
		Kelch 3	389..444		18/54 (33%)
		KELCH repeat	434..480	CDD:276965	14/48 (29%)
		Kelch 4	446..492		14/48 (29%)
		Kelch 5	494..538		10/44 (23%)
		KELCH repeat	528..568	CDD:276965	14/38 (37%)
		Kelch 6	539..585		12/27 (44%)