DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and KBTBD8

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_115894.2	Gene:	KBTBD8 / 84541	HGNCID:	30691	Length:	601	Species:	Homo sapiens

Alignment Length:	566	Identity:	151/566 - (26%)
Similarity:	249/566 - (43%)	Gaps:	128/566 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LFKEIRRM---GKLCDVTLKVE-DQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIE 88
            :.|:::.|   |:|.|:.::|: .:|||.||.||||..|||.:|||:.:.||..||:.:  ..:|
Human    35 ILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI--VGVE 97

  Fly    89 PSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSM 153
            ..:::.::||.|:.:|.:...|||.|...||..|:.:::|.||.::||...|.|.:|:..|||..
Human    98 AESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHY 162

  Fly   154 ICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDK 218
            ..::|.|.:.:||.:.|..|::.:|||.|..:||:.::..|:|||..||.::|:.::|.::.:::
Human   163 GHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNE 227

  Fly   219 RSELFPQVLA-AVRLPLLS--------PQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRG 274
            |....|::.| .:|.||:.        ||| |..:|:        .|.:              :|
Human   228 REVHLPEIFAKCIRFPLMEDTFIEKIPPQF-AQAIAK--------SCVE--------------KG 269

  Fly   275 LLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNG 339
            ...:....||.|...:..|..............||...|                      ::.|
Human   270 PSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLD----------------------IVTG 312

  Fly   340 KLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCK----RSAVGV-AALDDCIYVCGGYDGVTS 399
            :::                             .|||    ...||: .:.|:.||:.|||...:|
Human   313 RVF-----------------------------KLCKPPNDLREVGILVSPDNDIYIAGGYRPSSS 348

  Fly   400 LNTVE--------VYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGH----DGLSIFDSVER 452
            ..:::        :|...:|.|.:...:::.|....:....|.:||:||.    ||.:...|||.
Human   349 EVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVEC 413

  Fly   453 YDQAEDVWVKMSPMLNRRCRLGVA-------TLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLV 510
            ||..|:.|..:       |.:.||       ....||||..   |..||    .|:||.|.|..:
Human   414 YDSRENCWTTV-------CAMPVAMEFHNAVEYKEKIYVLQ---GEFFL----FYEPQKDYWGFL 464

  Fly   511 TPMNCKRSRVALAANMGKLWAIGGYDG-ESNLSTVEVYDPETDKWT 555
            |||...|.:...|.....::.|.|..| ...:.|||.||.|.:|||
Human   465 TPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWT 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	40/109 (37%)
		PHA03098	36..510	CDD:222983	132/507 (26%)
		BACK	143..245	CDD:285009	34/110 (31%)
		Kelch	292..339	CDD:128874	4/46 (9%)
		KELCH repeat	329..372	CDD:276965	1/42 (2%)
		Kelch	340..386	CDD:128874	5/50 (10%)
		KELCH repeat	376..417	CDD:276965	12/49 (24%)
		Kelch	387..433	CDD:128874	10/53 (19%)
		KELCH repeat	423..466	CDD:276965	15/46 (33%)
		Kelch	435..480	CDD:128874	16/55 (29%)
		Kelch_1	469..514	CDD:279660	17/51 (33%)
		KELCH repeat	470..514	CDD:276965	17/50 (34%)
		Kelch_1	517..560	CDD:279660	14/40 (35%)
		KELCH repeat	517..560	CDD:276965	14/40 (35%)
KBTBD8	NP_115894.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		BTB	39..144	CDD:279045	39/106 (37%)
		PHA03098	50..516	CDD:222983	147/551 (27%)
		BACK	153..250	CDD:285009	30/96 (31%)
		KELCH repeat	330..376	CDD:276965	10/45 (22%)
		Kelch 1. /evidence=ECO:0000255	336..390		10/53 (19%)
		Kelch	337..388	CDD:128874	10/50 (20%)
		Kelch_1	379..428	CDD:279660	16/55 (29%)
		KELCH repeat	380..428	CDD:276965	16/54 (30%)
		Kelch 2. /evidence=ECO:0000255	391..441		16/56 (29%)
		KELCH repeat	431..467	CDD:276965	13/42 (31%)
		Kelch 3. /evidence=ECO:0000255	443..481		16/44 (36%)
		Kelch_1	470..516	CDD:279660	14/41 (34%)
		Kelch 4. /evidence=ECO:0000255	483..532		12/28 (43%)
		KELCH repeat	519..571	CDD:276965
		Kelch 5. /evidence=ECO:0000255	542..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810