DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and AT1G55270

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_564684.1	Gene:	AT1G55270 / 841972	AraportID:	AT1G55270	Length:	434	Species:	Arabidopsis thaliana

Alignment Length:	452	Identity:	111/452 - (24%)
Similarity:	172/452 - (38%)	Gaps:	106/452 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 RFHPHNVLGIRTFADSMICRQLIDAADKY--IDQNFAKVSQSEEFLALDCEQLLELMRRDELNVR 199
            |..|:...|.|..|      .|:|:...|  :|.....|.::.:|:...     :|..:.::|..
plant     7 RQSPNGSRGFRLQA------PLVDSVSCYCRVDSGLKTVVEARKFVPGS-----KLCIQPDINPN 60

  Fly   200 TEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAK 264
            ...         .|.::.:|:.:.|.:|..          |.|.:|...|||....      |.:
plant    61 AHR---------RKNSKRERTRIQPPLLPG----------LPDDLAVACLIRVPRA------EHR 100

  Fly   265 DFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVE----------IYDPLTKKW 319
            ...|:.:|       ..|..||.||..|...:|   .:.|.|...:          .:||:::.|
plant   101 KLRLVCKR-------WYRLASGNFFYSQRKLLG---MSEEWVYVFKRDRDGKISWNTFDPISQLW 155

  Fly   320 KMGEQMSMMRSRV---GVAVLNG-KLYAFGG---FNGTERLSTVEVYDPRKNKWSQGCAMLCKRS 377
            :....:....|..   |.|||:| .||.|||   ..|:.|  .|..|:.|.|||.:...||.||.
plant   156 QPLPPVPREYSEAVGFGCAVLSGCHLYLFGGKDPLRGSMR--RVIFYNARTNKWHRAPDMLRKRH 218

  Fly   378 AVGVAALDDCIYVCGG-YDGV-TSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVY---- 436
            ..|...:::|:||.|| .:|: .:|.:.|||.|..|.|..:|.|     :..:..|.|.||
plant   219 FFGCCVINNCLYVAGGECEGIQRTLRSAEVYDPNKNRWSFIADM-----STAMVPLIGVVYDKKW 278

  Fly   437 ---ALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIY--VCGGYCGNSFLRS 496
               .||.|.    ....|.||...:.|..:|..:....|....:|||::|  .|...|      .
plant   279 FLKGLGSHQ----LVMSEAYDPEVNSWSPVSDGMVAGWRNPCTSLNGRLYGLDCRDGC------K 333

  Fly   497 VECYDPQTDTWKLVTPMNCKR--------SRVALAANMGKLWAIGGYDGESNLSTVEVYDPE 550
            :..:|..||:|...  |:.|.        ...||.....||..|   ....::|.|:|.:|:
plant   334 LRVFDESTDSWNKF--MDSKAHLGNSKSLEAAALVPLHNKLCII---RNNMSMSLVDVSNPD 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045
		PHA03098	36..510	CDD:222983	100/402 (25%)
		BACK	143..245	CDD:285009	17/103 (17%)
		Kelch	292..339	CDD:128874	12/59 (20%)
		KELCH repeat	329..372	CDD:276965	19/49 (39%)
		Kelch	340..386	CDD:128874	18/48 (38%)
		KELCH repeat	376..417	CDD:276965	15/42 (36%)
		Kelch	387..433	CDD:128874	16/47 (34%)
		KELCH repeat	423..466	CDD:276965	12/49 (24%)
		Kelch	435..480	CDD:128874	12/51 (24%)
		Kelch_1	469..514	CDD:279660	11/46 (24%)
		KELCH repeat	470..514	CDD:276965	11/45 (24%)
		Kelch_1	517..560	CDD:279660	9/42 (21%)
		KELCH repeat	517..560	CDD:276965	9/42 (21%)
AT1G55270	NP_564684.1	F-box	77..119	CDD:395521	14/64 (22%)
		KELCH repeat	170..213	CDD:276965	18/44 (41%)
		PHA03098	<171..356	CDD:222983	63/203 (31%)
		KELCH repeat	217..263	CDD:276965	17/50 (34%)
		KELCH repeat	266..306	CDD:276965	11/43 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960