DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and KBTBD7

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_115514.2	Gene:	KBTBD7 / 84078	HGNCID:	25266	Length:	684	Species:	Homo sapiens

Alignment Length:	573	Identity:	151/573 - (26%)
Similarity:	242/573 - (42%)	Gaps:	95/573 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LCDVTLKV--------EDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALES 94
            |||||::|        ..:.||.:|.||||..|||.:|||..|.||:...:||.:  ::..:.|.
Human    62 LCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHD--VDAESFEV 124

  Fly    95 LINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLI 159
            |::|.|:|:|.:...|||.|...:..|||..||:||||||..|....|...|..|||:....:|.
Human   125 LVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLR 189

  Fly   160 DAADKYIDQNFAKVSQ----SEEFLA-LDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKR 219
            ..|..||..||.::|:    .||.|| |...|||.::|.|.|::.:|..:....::|::.|..:|
Human   190 SQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKER 254

  Fly   220 SELFPQVLAAVRLPLLSPQFLADRVAREELIRS---SHQCRDLLDEAKDFHLMPERRGLLQSFRT 281
            .....:|...||....:.:   |:...|.|:..   ...|.|:::            |.||
Human   255 GPSAAEVFKCVRWMHFTEE---DQDYLEGLLTKPIVKKYCLDVIE------------GALQ---- 300

  Fly   282 RQRSGEFFTGQIYAVGGLASTGES----VSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVL----- 337
             .|.|:.....:..|...:|:..|    ||..|  :|..:.....::|.:.........|
Human   301 -MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAE--NPPQRLGMCAKEMVIFFGHPRDPFLCYDPY 362

  Fly   338 NGKLYA----FGGFNGTERLST--------------------VEVYDPRKNKWSQGCAMLCKRSA 378
            :|.:|.    ...|..|:.:::                    :.||.|.:|.|.|....|..|..
Human   363 SGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREG 427

  Fly   379 VGVAALDDCIYVCGGYDGVT--SLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGH 441
            :.||.|:..||:.||.|.:|  .|..||.|..:.|.|..||.:.....:..:..:..|:||:...
Human   428 MDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSK 492

  Fly   442 DGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIY-VCGGYCGNSFLRSVECYDPQTD 505
            ..|.       ||.:.::|:..: .|.|.........|.:|| :|.       :..::.|:|...
Human   493 RMLC-------YDPSHNMWLNCA-SLKRSDFQEACVFNDEIYCICD-------IPVMKVYNPARG 542

  Fly   506 TWKLVT--PMNCKRSRVALAANMGKLWAIGGY--DGESNLSTVEVYDPETDKW 554
            .|:.::  |::.:.....:..:..||..|...  ..:.|..||..||...|:|
Human   543 EWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQW 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	44/104 (42%)
		PHA03098	36..510	CDD:222983	140/523 (27%)
		BACK	143..245	CDD:285009	30/106 (28%)
		Kelch	292..339	CDD:128874	9/55 (16%)
		KELCH repeat	329..372	CDD:276965	11/71 (15%)
		Kelch	340..386	CDD:128874	14/69 (20%)
		KELCH repeat	376..417	CDD:276965	16/42 (38%)
		Kelch	387..433	CDD:128874	14/47 (30%)
		KELCH repeat	423..466	CDD:276965	7/42 (17%)
		Kelch	435..480	CDD:128874	8/44 (18%)
		Kelch_1	469..514	CDD:279660	9/47 (19%)
		KELCH repeat	470..514	CDD:276965	8/46 (17%)
		Kelch_1	517..560	CDD:279660	10/40 (25%)
		KELCH repeat	517..560	CDD:276965	10/40 (25%)
KBTBD7	NP_115514.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		BTB_POZ_KBTBD6_7	37..178	CDD:349582	48/117 (41%)
		PHA03098	55..544	CDD:222983	139/520 (27%)
		BACK_KBTBD6_7	168..270	CDD:350557	30/101 (30%)
		KELCH repeat	384..421	CDD:276965	6/36 (17%)
		Kelch 1	386..435		11/48 (23%)
		KELCH repeat	425..471	CDD:276965	18/45 (40%)
		Kelch 2	436..484		14/47 (30%)
		KELCH repeat	474..511	CDD:276965	7/44 (16%)
		Kelch 3	486..523		8/44 (18%)
		KELCH repeat	512..551	CDD:276965	8/45 (18%)
		Kelch 4	524..564		7/46 (15%)
		Kelch 5	567..616		10/29 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..666
		ATG8 interaction motif (AIM). /evidence=ECO:0000269\|PubMed:25684205	668..671
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910