DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and AT1G27420

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_174062.1	Gene:	AT1G27420 / 839632	AraportID:	AT1G27420	Length:	346	Species:	Arabidopsis thaliana

Alignment Length:	391	Identity:	97/391 - (24%)
Similarity:	140/391 - (35%)	Gaps:	146/391 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 EVIFEACMKWVKYAEDKRSELFPQVLAAVR-LPLLSPQFLADRVAREELIRSSHQCRDLLDEAKD 265
            ::..:.|.:|       ||.|..|..|||| |.....:||.       ::..|...||:..|..|
plant    32 QITSQVCRRW-------RSFLRSQHFAAVRKLTGTVEEFLC-------VLMESECGRDVYWEVFD 82

  Fly   266 FHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRS 330
                              .||... |||..|.|               ||.:.:
plant    83 ------------------ASGNKL-GQIPPVPG---------------PLKRGF----------- 102

  Fly   331 RVGVAVLN-GKLYAFGGF--------NGTERLSTVEVY--DPRKNKWSQGCAMLCKRSAVGVAAL 384
              |||||: ||:..|||:        |.|...::.:||  ||..|.|.:...|...|.....|.:
plant   103 --GVAVLDGGKIVFFGGYTEVEGSGINSTTVSASADVYEFDPANNSWRKLAGMNIPRYNFAFAEV 165

  Fly   385 DDCIYVCGGYDGVT-SLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFD 448
            :..:||..||...| ||:..|||.||:|.|                               |:..
plant   166 NGLLYVIRGYSTDTYSLSNAEVYNPKTNQW-------------------------------SLMH 199

  Fly   449 SVERYDQAEDVWVKMSPMLNRRCRLGVA-TLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTP 512
            ...|     .||            .|.| ..:.|:|..|.  |:.|   ::.|||:|.||:   .
plant   200 CPNR-----PVW------------RGFAFAFSSKLYAVGN--GSRF---IDIYDPKTQTWE---E 239

  Fly   513 MNCKRSRVALAANM--GKLWAIGGYDGESNL-STVEVYDPETDKWT--FMPPMCAHSGG--VGAG 570
            :|.::|....:..:  .|:     |..:.|: ..:.|:|||.:.|:  |:||   ..||  |..|
plant   240 LNSEQSVSVYSYTVVRNKV-----YFMDRNMPGRLGVFDPEENSWSSVFVPP---REGGFWVRLG 296

  Fly   571 V 571
            |
plant   297 V 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045
		PHA03098	36..510	CDD:222983	79/321 (25%)
		BACK	143..245	CDD:285009	13/43 (30%)
		Kelch	292..339	CDD:128874	11/47 (23%)
		KELCH repeat	329..372	CDD:276965	18/53 (34%)
		Kelch	340..386	CDD:128874	15/55 (27%)
		KELCH repeat	376..417	CDD:276965	16/41 (39%)
		Kelch	387..433	CDD:128874	14/46 (30%)
		KELCH repeat	423..466	CDD:276965	4/42 (10%)
		Kelch	435..480	CDD:128874	6/45 (13%)
		Kelch_1	469..514	CDD:279660	13/45 (29%)
		KELCH repeat	470..514	CDD:276965	13/44 (30%)
		Kelch_1	517..560	CDD:279660	11/47 (23%)
		KELCH repeat	517..560	CDD:276965	11/47 (23%)
AT1G27420	NP_174062.1	F-box	9..50	CDD:395521	6/24 (25%)
		PHA03098	<81..286	CDD:222983	73/312 (23%)
		KELCH repeat	100..153	CDD:276965	18/65 (28%)
		KELCH repeat	157..202	CDD:276965	17/75 (23%)
		KELCH repeat	205..242	CDD:276965	15/56 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960