DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and AT1G16250

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001321591.1	Gene:	AT1G16250 / 838194	AraportID:	AT1G16250	Length:	383	Species:	Arabidopsis thaliana

Alignment Length:	365	Identity:	86/365 - (23%)
Similarity:	133/365 - (36%)	Gaps:	94/365 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 RSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGES-------VST 308
            ||.:|......||..:|.:|..|.:...:.....:....:..:..:||..:...|       |.|
plant    68 RSKNQWVAYDPEADRWHPLPRTRAVQDGWHHSGFACVCVSNCLLVIGGCYAPSVSSFPHQKPVVT 132

  Fly   309 VEI--YDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTER--LSTVEVYDPRKNKWSQG 369
            .::  :||..|:|||...|...|:......::||:|..||.|.|..  :.:.|||||..::|.:.
plant   133 KDVMRFDPFKKQWKMVASMRTPRTHFACTSVSGKVYVAGGRNLTHSRGIPSAEVYDPVADRWEEL 197

  Fly   370 CAMLCKRSAVGVAALD--DCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLN 432
            .||  .|..:..:.|.  .|.:|.....|....|:.||:.|:..||.||
plant   198 PAM--PRPQMDCSGLSYRGCFHVLSDQVGFAEQNSSEVFNPRDMTWSTV---------------- 244

  Fly   433 GYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATL-NGKIYVCGGYCGNSFLRS 496
                                    ||||     ..:|..:..|..: |.::|....: |.|.:::
plant   245 ------------------------EDVW-----PFSRAMQFAVQVMKNDRVYTIVDW-GESLIKT 279

  Fly   497 VECYDPQTDTW-------KLVTPMNCKRSRVA----LAANMGKLWAIGG------------YDGE 538
               .|.....|       .:|.| |..|...|    .||...:|:.|||            :| .
plant   280 ---RDTDEGEWYNVGSVPSVVLP-NHPRELEAFGYGFAALRNELYVIGGKVLKWEESGAGRFD-I 339

  Fly   539 SNLSTVEVYDPETDK---WTFMPPMCAHSGGVGAGVIRIE 575
            ..|..|.|.:| .|:   |....|||..:||...|.:.:|
plant   340 VRLPVVRVCNP-LDRPLNWRETKPMCIPAGGSIIGCVSLE 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045
		PHA03098	36..510	CDD:222983	61/279 (22%)
		BACK	143..245	CDD:285009
		Kelch	292..339	CDD:128874	13/55 (24%)
		KELCH repeat	329..372	CDD:276965	14/44 (32%)
		Kelch	340..386	CDD:128874	16/49 (33%)
		KELCH repeat	376..417	CDD:276965	12/42 (29%)
		Kelch	387..433	CDD:128874	11/45 (24%)
		KELCH repeat	423..466	CDD:276965	4/42 (10%)
		Kelch	435..480	CDD:128874	6/45 (13%)
		Kelch_1	469..514	CDD:279660	10/52 (19%)
		KELCH repeat	470..514	CDD:276965	9/51 (18%)
		Kelch_1	517..560	CDD:279660	15/61 (25%)
		KELCH repeat	517..560	CDD:276965	15/61 (25%)
AT1G16250	NP_001321591.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960