DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and AT5G60570

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001331512.1	Gene:	AT5G60570 / 836178	AraportID:	AT5G60570	Length:	393	Species:	Arabidopsis thaliana

Alignment Length:	277	Identity:	71/277 - (25%)
Similarity:	103/277 - (37%)	Gaps:	52/277 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 MSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVE-----VYDPR--------KNKWSQGCAMLC-- 374
            :|.:..:....:.:|.|:|.     .:.|..||     |.|||        |.||.....|.|
plant    73 LSCVNKKYNKLINSGHLFAL-----RKELGIVEYLVFMVCDPRGWLMFSPMKKKWMVLPKMPCDE 132

  Fly   375 ------KRSAVGVAALDDCIYVCGGYDGVTSLNTVEV--YYPKSNTWKTVAQMMKYRSAGGVTQL 431
                  |.|    .|:||.:.|.|     ..|....:  |..:|..|.....|.:.|.......|
plant   133 CFNHADKES----LAVDDELLVFG-----RELFQFAIWKYSLRSRCWVKCEGMHRPRCLFASGSL 188

  Fly   432 NGYVYALGGHD-GLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCG-NSFL 494
            .|.....||.| ..:|..|.|.||.:...|..:..|.:.|.......::||.||.||... |..:
plant   189 GGIAIVAGGTDMNGNILASAELYDSSSGRWEMLPNMHSPRRLCSGFFMDGKFYVIGGMSSPNVSV 253

  Fly   495 RSVECYDPQTDTWKLVTPMNCKRSRVALAANM-----GKLWAIGGYDGESNLSTVEVYDPETDKW 554
            ...|.:|.:|..|:.:..|....:|.|.|..:     .:|:.:     |.:.:.|:.||...:||
plant   254 TFGEEFDLETRKWRKIEGMYPNVNRAAQAPPLVVVVNNELFTL-----EYSTNMVKKYDKVKNKW 313

  Fly   555 TFM---PPMCAHSGGVG 568
            ..|   |||...|.|.|
plant   314 EVMGRLPPMVDSSNGWG 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045
		PHA03098	36..510	CDD:222983	53/209 (25%)
		BACK	143..245	CDD:285009
		Kelch	292..339	CDD:128874	1/13 (8%)
		KELCH repeat	329..372	CDD:276965	13/55 (24%)
		Kelch	340..386	CDD:128874	17/66 (26%)
		KELCH repeat	376..417	CDD:276965	10/42 (24%)
		Kelch	387..433	CDD:128874	9/47 (19%)
		KELCH repeat	423..466	CDD:276965	12/43 (28%)
		Kelch	435..480	CDD:128874	11/45 (24%)
		Kelch_1	469..514	CDD:279660	12/45 (27%)
		KELCH repeat	470..514	CDD:276965	12/44 (27%)
		Kelch_1	517..560	CDD:279660	12/50 (24%)
		KELCH repeat	517..560	CDD:276965	12/50 (24%)
AT5G60570	NP_001331512.1	F-box	50..93	CDD:366220	4/24 (17%)
		PHA03098	<120..325	CDD:222983	56/218 (26%)
		KELCH repeat	180..225	CDD:276965	12/44 (27%)
		KELCH repeat	228..272	CDD:276965	12/43 (28%)
		KELCH repeat	278..320	CDD:276965	11/46 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960