DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and AT5G48980

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_199709.1	Gene:	AT5G48980 / 834957	AraportID:	AT5G48980	Length:	399	Species:	Arabidopsis thaliana

Alignment Length:	295	Identity:	67/295 - (22%)
Similarity:	97/295 - (32%)	Gaps:	96/295 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 KKWKMGEQMSMMRSRVGVAVLNGK-------------LYAFGGFNGTERLSTVEVYDPRKNKWSQ 368
            ||.|..|:.|.:.....:::||..             |||..........|.|...|.|.:.|::
plant   119 KKKKKKEEKSSVNLLAPISILNSHPVEWSAIISVDHYLYAISADIEKAPYSNVPYLDCRTHTWNE 183

  Fly   369 GCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTV---AQMMKYRSAGGVTQ 430
            ...|   |.|...:..:..:|:.|.::...|||.||||...:.|||.|   .:|.|      :..
plant   184 APRM---RLAHTNSEFEGIVYLPGSFESPDSLNCVEVYNTMTQTWKPVPPEKRMFK------LEN 239

  Fly   431 LNGYVYALGGH-------------------DGLSIFDSVERYDQAEDVWVKMSPMLN------RR 470
            |...:|....|                   .||.:.|:|:.|       ::.|.|:.      |:
plant   240 LEKKIYYKSFHLDSRAGKGLSLSYKSKHLTCGLVVLDTVDSY-------LRSSCMIENIAYFYRK 297

  Fly   471 CRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGK---LW-- 530
            .......|:|||.|.|...|...|                 |...:.|.|.||...||   ||
plant   298 GNFIWRGLDGKILVYGKIEGLEGL-----------------PKFSRYSSVQLAEYGGKLVVLWDK 345

  Fly   531 --AIGGY---------------DGESNLSTVEVYD 548
              ...||               :|:.....||.:|
plant   346 YVPASGYKEKMIWCAEISLEKRNGKEIWGNVEWFD 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045
		PHA03098	36..510	CDD:222983	52/233 (22%)
		BACK	143..245	CDD:285009
		Kelch	292..339	CDD:128874	6/21 (29%)
		KELCH repeat	329..372	CDD:276965	10/55 (18%)
		Kelch	340..386	CDD:128874	11/58 (19%)
		KELCH repeat	376..417	CDD:276965	15/43 (35%)
		Kelch	387..433	CDD:128874	16/48 (33%)
		KELCH repeat	423..466	CDD:276965	9/61 (15%)
		Kelch	435..480	CDD:128874	11/69 (16%)
		Kelch_1	469..514	CDD:279660	10/44 (23%)
		KELCH repeat	470..514	CDD:276965	9/43 (21%)
		Kelch_1	517..560	CDD:279660	14/54 (26%)
		KELCH repeat	517..560	CDD:276965	14/54 (26%)
AT5G48980	NP_199709.1	F-box	34..75	CDD:279040
		KELCH repeat	148..187	CDD:276965	8/38 (21%)
		Kelch_1	187..230	CDD:279660	16/45 (36%)
		KELCH repeat	188..230	CDD:276965	15/41 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910