DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and AT5G28180

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_198170.1	Gene:	AT5G28180 / 832894	AraportID:	AT5G28180	Length:	352	Species:	Arabidopsis thaliana

Alignment Length:	388	Identity:	79/388 - (20%)
Similarity:	145/388 - (37%)	Gaps:	115/388 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 FLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQS-EEFLALDCEQLLELMRRDEL 196
            |::|..:       :||:........:...|:.:....|::|:| ...|:|.|:....|:..:||
plant    19 FVVSLLY-------KTFSRKEKKLTFLSLPDEIVLNCLARISRSYYPKLSLVCKTFRTLLISNEL 76

  Fly   197 NV-----RTEEVIFEACMK------------WVKYAED-----KRSELFPQVLAAVRLP----LL 235
            .|     :|.|..|..|:|            |:|..:.     :::|........|::|    .:
plant    77 TVARVQLKTYESFFHVCLKFPDKPNPSMFTLWIKPGQILTNQLEKNERSTGATRLVQIPSSYCSI 141

  Fly   236 SPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLL------QSFRTRQRSGEFFTGQIY 294
            .|.:|.. |..|....|.|.     |.:.:. .:..:..|.      .:....:..|..:.|::|
plant   142 VPHYLIS-VGSEVYGLSQHN-----DPSSNM-FVRNKEDLFWCNAPNMTVARAKAIGHAYNGKLY 199

  Fly   295 AVGGLASTGESVSTVEIYDPLTKKWKM----GEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLST 355
            .:|| ....|||:..|::||.|:.|:.    |.::.....| .:.|...|||.    :..|::.:
plant   200 VMGG-CRDDESVNWGEVFDPKTQTWEALPDPGSELRFSSIR-KIDVFQEKLYV----SSNEKIDS 258

  Fly   356 VEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYV-CGGYDGVTSLNTVEVYYPKSNTWKTVAQM 419
              ||||::.||:     :.::|.|      .|:.: ||                          |
plant   259 --VYDPKEGKWN-----VAEKSPV------QCMNLGCG--------------------------M 284

  Fly   420 MKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKI 482
            ::..:.||..              |.::|.| ...|.:|:|..:..:..|.   ||..:.|||
plant   285 IEIANYGGKL--------------LILWDKV-GLSQDKDIWCAVIALEKRD---GVDEVWGKI 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	1/1 (100%)
		PHA03098	36..510	CDD:222983	79/388 (20%)
		BACK	143..245	CDD:285009	25/128 (20%)
		Kelch	292..339	CDD:128874	14/50 (28%)
		KELCH repeat	329..372	CDD:276965	12/42 (29%)
		Kelch	340..386	CDD:128874	12/45 (27%)
		KELCH repeat	376..417	CDD:276965	5/41 (12%)
		Kelch	387..433	CDD:128874	6/46 (13%)
		KELCH repeat	423..466	CDD:276965	8/42 (19%)
		Kelch	435..480	CDD:128874	9/44 (20%)
		Kelch_1	469..514	CDD:279660	6/14 (43%)
		KELCH repeat	470..514	CDD:276965	5/13 (38%)
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
AT5G28180	NP_198170.1	F-box	36..78	CDD:279040	10/41 (24%)
		KELCH repeat	186..231	CDD:276965	13/45 (29%)
		Kelch_1	192..230	CDD:279660	12/38 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910