DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and AT4G25710

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_194301.1	Gene:	AT4G25710 / 828676	AraportID:	AT4G25710	Length:	390	Species:	Arabidopsis thaliana

Alignment Length:	265	Identity:	62/265 - (23%)
Similarity:	98/265 - (36%)	Gaps:	71/265 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 STGESVSTVEI-YDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERL-----STVEVY 359
            |:|..::.:.| :.|||:::.:             |.:...:|..    |..|.     |:|.|.
plant   116 SSGYVLARIPIPHSPLTQRYSL-------------AAVGSNIYNI----GVTRYHHLTSSSVWVL 163

  Fly   360 DPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGY--DGVTSL-NTVEVYYPKSNTWKTVA---- 417
            |.|.:.|.|..::..:...|.|:.||..|||.|.:  ||..|| |:|.|...::.....||
plant   164 DCRSHTWRQAPSLPVELFRVSVSVLDQKIYVAGLHQEDGSDSLKNSVTVLDTETQVSDRVAIPCS 228

  Fly   418 -----QMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVK----MSPMLNRRCRL 473
                 ::....|.||...|         ..|..:.|    |:..|..|.:    |...:..:|
plant   229 VSQGKEIFISTSVGGKVNL---------VTGRKVVD----YNPVEGSWEEVGDTMCEFMFSKC-- 278

  Fly   474 GVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLV-------TPMNCKRSRVALAANMGKL-- 529
             ...:...:|.|      :..|....||.:..||:.:       .|....|:.|:||...|||
plant   279 -FCVVGNVLYSC------AIDRVFRWYDTEVRTWRNLECLIGGRLPKLSPRAFVSLADYGGKLAV 336

  Fly   530 -WAIG 533
             |..|
plant   337 FWNQG 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045
		PHA03098	36..510	CDD:222983	52/230 (23%)
		BACK	143..245	CDD:285009
		Kelch	292..339	CDD:128874	7/38 (18%)
		KELCH repeat	329..372	CDD:276965	11/47 (23%)
		Kelch	340..386	CDD:128874	13/50 (26%)
		KELCH repeat	376..417	CDD:276965	15/43 (35%)
		Kelch	387..433	CDD:128874	17/57 (30%)
		KELCH repeat	423..466	CDD:276965	10/46 (22%)
		Kelch	435..480	CDD:128874	7/48 (15%)
		Kelch_1	469..514	CDD:279660	9/51 (18%)
		KELCH repeat	470..514	CDD:276965	9/50 (18%)
		Kelch_1	517..560	CDD:279660	9/20 (45%)
		KELCH repeat	517..560	CDD:276965	9/20 (45%)
AT4G25710	NP_194301.1	F-box	29..72	CDD:279040
		KELCH repeat	134..176	CDD:276965	11/58 (19%)
		Kelch	<156..189	CDD:128874	9/32 (28%)
		Kelch_2	180..226	CDD:284956	17/45 (38%)
		KELCH repeat	180..221	CDD:276965	15/40 (38%)
		KELCH repeat	222..268	CDD:276965	11/58 (19%)
		KELCH repeat	274..311	CDD:276965	8/45 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910