DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and AT4G02310

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_192140.1	Gene:	AT4G02310 / 828070	AraportID:	AT4G02310	Length:	349	Species:	Arabidopsis thaliana

Alignment Length:	339	Identity:	64/339 - (18%)
Similarity:	111/339 - (32%)	Gaps:	113/339 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 VSQSEEFLALDCEQLL--ELMRRDELNVRTEEVIFEACMK------------WVKYAEDKRSELF 223
            ||::..||....|..:  .|:.:|.         |..|.:            |..:.|::|
plant    39 VSKNLRFLVSSSELKITRSLLEKDR---------FYVCFQEHSNSPSLTTYHWFSFTENRR---- 90

  Fly   224 PQVLAAVRLPLLSP--QFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSG 286
                ..|.:|..||  .:.|                       ...|.||
plant    91 ----CLVSIPFTSPVEPYFA-----------------------TLTLGPE--------------- 113

  Fly   287 EFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTE 351
                  ||.||...|       :.|.|..:.|.:.|.:..:...:..|.::|.|:|.|||.:...
plant   114 ------IYFVGKSRS-------MWILDSRSGKLRQGPRPLVACDQAAVGLVNDKIYVFGGIDDMN 165

  Fly   352 RL----STVEVYDPRKNKWSQG----CAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYP 408
            :.    ...:|:|.:...|..|    ..:.|...:|...:|...|||.|....||      :|..
plant   166 KRYYEGIHAQVFDLKTQTWHVGPNLSVKLACLNRSVVTPSLGRKIYVRGTDRDVT------IYDI 224

  Fly   409 KSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVW-----VKMSPMLN 468
            |......:.....: |:|.:..::..:|....:.||..::|.|:.      |     ::.:.:.|
plant   225 KDGKCDKIIPADDF-SSGDMCVVDNVIYMYYHNVGLMWYESKEKQ------WSVVHGLEFNGVFN 282

  Fly   469 RRCRLGVATLNGKI 482
               .:.:|..|||:
plant   283 ---SIAIAEYNGKL 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045
		PHA03098	36..510	CDD:222983	64/339 (19%)
		BACK	143..245	CDD:285009	17/87 (20%)
		Kelch	292..339	CDD:128874	10/46 (22%)
		KELCH repeat	329..372	CDD:276965	11/50 (22%)
		Kelch	340..386	CDD:128874	12/53 (23%)
		KELCH repeat	376..417	CDD:276965	10/40 (25%)
		Kelch	387..433	CDD:128874	10/45 (22%)
		KELCH repeat	423..466	CDD:276965	8/47 (17%)
		Kelch	435..480	CDD:128874	8/49 (16%)
		Kelch_1	469..514	CDD:279660	4/14 (29%)
		KELCH repeat	470..514	CDD:276965	4/13 (31%)
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
AT4G02310	NP_192140.1	F-box	11..58	CDD:279040	5/18 (28%)
		KELCH repeat	104..139	CDD:276965	13/85 (15%)
		KELCH repeat	143..191	CDD:276965	11/47 (23%)
		Kelch_1	146..191	CDD:279660	11/44 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910