DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and SKIP4

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001327045.1	Gene:	SKIP4 / 825307	AraportID:	AT3G61350	Length:	358	Species:	Arabidopsis thaliana

Alignment Length:	230	Identity:	59/230 - (25%)
Similarity:	92/230 - (40%)	Gaps:	26/230 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 PRKNKWSQGCA------MLCK------RSAVGVAALDDCIY-VCGGYDGVTSLNTVEVYYPKSNT 412
            ||:...:..|.      .:|.      |:...:|  :..|| :|....|...|:.:..:..: .:
plant    38 PREYHMAMKCVSRRWRDFVCSDEMCDYRNEFNLA--ESWIYALCRDISGGVFLHMLNPFSSR-RS 99

  Fly   413 WKTVAQ--MMKYRSAGGVTQLNGYVYALGGHDGL-SIFDSVERYDQAEDVWVKMSPMLN-RRCRL 473
            ||.:..  .:..|...|...|...::.|||...| ...|.:..||.|.:.|..:.|.|: :||..
plant   100 WKRINDYPYIPMREGMGFAVLGKRLFVLGGCGWLEDATDEIYCYDAAMNTWFDVVPPLSTKRCYF 164

  Fly   474 GVATLNGKIYVCGGYCGN-SFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDG 537
            ...||:|||...||...| :..|:.:.|||.|.|.|..:.:|............|:::..||..|
plant   165 ACETLDGKIIAIGGLGLNPNAKRTWDIYDPLTRTCKSCSDVNIVPEMEDSFVMDGRIYIRGGVGG 229

  Fly   538 ESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVI 572
                |:..||...:..|..|....| ||..|..|:
plant   230 ----SSTAVYSASSGIWERMDDDMA-SGWRGPAVV 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045
		PHA03098	36..510	CDD:222983	44/166 (27%)
		BACK	143..245	CDD:285009
		Kelch	292..339	CDD:128874
		KELCH repeat	329..372	CDD:276965	3/16 (19%)
		Kelch	340..386	CDD:128874	6/36 (17%)
		KELCH repeat	376..417	CDD:276965	9/41 (22%)
		Kelch	387..433	CDD:128874	10/48 (21%)
		KELCH repeat	423..466	CDD:276965	12/43 (28%)
		Kelch	435..480	CDD:128874	15/46 (33%)
		Kelch_1	469..514	CDD:279660	17/45 (38%)
		KELCH repeat	470..514	CDD:276965	17/44 (39%)
		Kelch_1	517..560	CDD:279660	9/42 (21%)
		KELCH repeat	517..560	CDD:276965	9/42 (21%)
SKIP4	NP_001327045.1	F-box	22..60	CDD:395521	4/21 (19%)
		PRK14131	83..>150	CDD:237617	15/67 (22%)
		PHA03098	<100..322	CDD:222983	48/165 (29%)
		KELCH repeat	112..157	CDD:276965	13/44 (30%)
		KELCH repeat	161..212	CDD:276965	18/50 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960