DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and AT3G06570

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_566286.1	Gene:	AT3G06570 / 819836	AraportID:	AT3G06570	Length:	390	Species:	Arabidopsis thaliana

Alignment Length:	451	Identity:	82/451 - (18%)
Similarity:	151/451 - (33%)	Gaps:	131/451 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 QNLMVGASFLQLSNVRDACASFL--ISRFHPHNVLGIRTFADSMIC---RQLIDAADKYIDQNFA 171
            |:....|||..|.:  |...|.:  :.|.:...|        |::|   |.|:.:.:.|..::.:
plant    18 QSQSASASFQSLPD--DLILSIVARVPRLYHRTV--------SLVCKSFRSLLVSPELYKARSVS 72

  Fly   172 KVSQSEEFLALDC---EQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLP 233
            ..::|..:|::.|   .::..|.|:.:..:.|.|             |:::.:.....||.|..|
plant    73 GHTESCLYLSIACYPDYRMFTLCRKPDQTLTTSE-------------EEEKKKSNGYYLAPVPDP 124

  Fly   234 LLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGG 298
            ...|.:.:..|.                                           ....||.:.|
plant   125 DSHPVYFSSLVT-------------------------------------------VGSDIYNIAG 146

  Fly   299 LASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLST----VEVY 359
                ..:.|.|.|.|..:..|:...::.:..:.|..:||:.|::..|.:...|...:    .||.
plant   147 ----SHASSNVSILDCRSNTWREAPRLGVELTSVSASVLDRKIFVVGMYADDEESESKNDFFEVL 207

  Fly   360 DPRKNKWSQ---GCA------MLCKRSAV-GVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWK 414
            |...:.|..   .|:      :.|:.:.: |...:...|     :.||.:.|:      |.:.|:
plant   208 DTETHTWDPQPFNCSETKDKFLNCRTAFIDGKFLVKPWI-----HRGVVAYNS------KESRWE 261

  Fly   415 TV-AQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATL 478
            .| .:|..........|::..:|       |:....:..||.|.:.|..:..:|    .||....
plant   262 PVQTKMAMSMFNDSYCQIHNVIY-------LAFDGRIRWYDDALNCWGDVQGLL----ELGNIPH 315

  Fly   479 NGKIYVCGGYCGN---SFLRSVECYDPQTD--TWKLVTPMNCKRSRVALAANMGKLWAIGG 534
            .........|.||   .:.|    |.|..|  .||::.   |  :.:||.....  |.|.|
plant   316 GPSCVRLADYRGNIAVFWFR----YLPDNDDYKWKMIW---C--AEIALERRTS--WEIWG 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	7/24 (29%)
		PHA03098	36..510	CDD:222983	76/425 (18%)
		BACK	143..245	CDD:285009	19/107 (18%)
		Kelch	292..339	CDD:128874	11/46 (24%)
		KELCH repeat	329..372	CDD:276965	11/55 (20%)
		Kelch	340..386	CDD:128874	10/59 (17%)
		KELCH repeat	376..417	CDD:276965	8/42 (19%)
		Kelch	387..433	CDD:128874	9/46 (20%)
		KELCH repeat	423..466	CDD:276965	7/42 (17%)
		Kelch	435..480	CDD:128874	9/44 (20%)
		Kelch_1	469..514	CDD:279660	11/49 (22%)
		KELCH repeat	470..514	CDD:276965	11/48 (23%)
		Kelch_1	517..560	CDD:279660	5/18 (28%)
		KELCH repeat	517..560	CDD:276965	5/18 (28%)
AT3G06570	NP_566286.1	F-box	29..67	CDD:395521	9/47 (19%)
		PHA03098	<126..313	CDD:222983	41/255 (16%)
		KELCH repeat	130..169	CDD:276965	9/85 (11%)
		KELCH repeat	173..218	CDD:276965	10/44 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910