DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and AT2G44030

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_181931.1	Gene:	AT2G44030 / 819008	AraportID:	AT2G44030	Length:	380	Species:	Arabidopsis thaliana

Alignment Length:	262	Identity:	61/262 - (23%)
Similarity:	93/262 - (35%)	Gaps:	76/262 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   347 FNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDD-------------CIYVCGGYDGVT 398
            ||...|:|  ..:||        ...|..:|...:.||.|             |:|||      .
plant    28 FNCLSRVS--RTHDP--------ILSLVSKSFRSLLALPDLEAERFRILKNETCLYVC------L 76

  Fly   399 SLNTVEVYYPKSNTWKTVAQMMKYR--------------SAGGVTQLNGYVYALGGHDGLSIFDS 449
            :||......|   :|..::|..|::              :...|......:|.|||      |.:
plant    77 NLNNNNNPNP---SWFILSQTPKHKLIPLPSLPYPDPHPNCSTVVSTGSEIYLLGG------FVA 132

  Fly   450 VER-------YDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSV---ECYDPQT 504
            .|:       .|.....|.::..|...|.......::|||.|.|| |.:.:..||   |.|||.|
plant   133 KEKRSRRAYVLDCKSHQWRRLPKMRIARKEAAANVIDGKINVYGG-CSSEYHNSVNWGEIYDPMT 196

  Fly   505 DTWKL----------VTPMNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPP 559
            .||:.          |.|....:..:|. .:.|.|.:...|| .:.:.|:: |:...||....|.
plant   197 QTWEPFPEGALNKEGVIPCALIKDGIAF-PDCGLLISGKVYD-TTTMDTLD-YNTPMDKLDLCPN 258

  Fly   560 MC 561
            :|
plant   259 VC 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045
		PHA03098	36..510	CDD:222983	48/209 (23%)
		BACK	143..245	CDD:285009
		Kelch	292..339	CDD:128874
		KELCH repeat	329..372	CDD:276965	6/24 (25%)
		Kelch	340..386	CDD:128874	10/38 (26%)
		KELCH repeat	376..417	CDD:276965	12/53 (23%)
		Kelch	387..433	CDD:128874	11/59 (19%)
		KELCH repeat	423..466	CDD:276965	9/63 (14%)
		Kelch	435..480	CDD:128874	10/51 (20%)
		Kelch_1	469..514	CDD:279660	19/57 (33%)
		KELCH repeat	470..514	CDD:276965	19/56 (34%)
		Kelch_1	517..560	CDD:279660	10/42 (24%)
		KELCH repeat	517..560	CDD:276965	10/42 (24%)
AT2G44030	NP_181931.1	F-box	19..64	CDD:279040	11/45 (24%)
		KELCH repeat	112..157	CDD:276965	9/50 (18%)
		Kelch_6	115..160	CDD:290672	10/50 (20%)
		Kelch_1	159..204	CDD:279660	17/45 (38%)
		KELCH repeat	160..204	CDD:276965	17/44 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910