DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and SKIP6

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_565522.1	Gene:	SKIP6 / 816731	AraportID:	AT2G21950	Length:	372	Species:	Arabidopsis thaliana

Alignment Length:	355	Identity:	81/355 - (22%)
Similarity:	126/355 - (35%)	Gaps:	73/355 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 LPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAV 296
            :||||.......:||  :.|..:....|:  :|.|..:|.                  :..:||.
plant    21 IPLLSEDVALSCLAR--VPRCHYPILSLV--SKTFRSLPT------------------SPLLYAT 63

  Fly   297 GGLASTGESVSTVEIYDP----------LTKKWKMGEQMSMM--------RSRVGVA--VLNGKL 341
            ..|....|::..|.|..|          |.:.........|:        .|.||.|  |::.::
plant    64 RALVGATENILYVAIRIPPESGACWFTLLHRTLSNSTNSKMLVPIPSCPSPSLVGSAYVVVDSEI 128

  Fly   342 YAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGY---DGVTSLNTV 403
            |..||.......|:|.|.|.|.:.|.:...|...|.......:|..|||.||.   :...|:|..
plant   129 YVIGGSIRDVPSSSVWVLDCRFHTWRRVSNMRVGREFAAAGVIDGKIYVIGGCVVDNWARSINWA 193

  Fly   404 EVYYPKSNTWKTVAQ-----MMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKM 463
            |::..|:.||:.||.     ..|:..|..|  :.|.|||:...:|:.       |:..|..|...
plant   194 EMFDIKTQTWEPVASPGMEVREKWMHASAV--MEGKVYAMADRNGVV-------YEPKEKKWEMP 249

  Fly   464 SPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMN------CKRSRVAL 522
            ...|:...| |.|.:...|..|..|.|     .:..|||:...|:.:..:.      |..:....
plant   250 EKRLDLGWR-GRACVIENILYCYDYLG-----KIRGYDPKERIWRELKGVESLPKFLCGATMANR 308

  Fly   523 AANMGKLWAIGGYDGESNLSTVEVYDPETD 552
            ...:..||.  |..|......:|::..|.|
plant   309 GGKLTVLWE--GKAGSGGSRRMEIWCAEID 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045
		PHA03098	36..510	CDD:222983	73/305 (24%)
		BACK	143..245	CDD:285009	4/12 (33%)
		Kelch	292..339	CDD:128874	14/66 (21%)
		KELCH repeat	329..372	CDD:276965	14/44 (32%)
		Kelch	340..386	CDD:128874	11/45 (24%)
		KELCH repeat	376..417	CDD:276965	13/43 (30%)
		Kelch	387..433	CDD:128874	16/53 (30%)
		KELCH repeat	423..466	CDD:276965	10/42 (24%)
		Kelch	435..480	CDD:128874	11/44 (25%)
		Kelch_1	469..514	CDD:279660	11/44 (25%)
		KELCH repeat	470..514	CDD:276965	11/43 (26%)
		Kelch_1	517..560	CDD:279660	7/36 (19%)
		KELCH repeat	517..560	CDD:276965	7/36 (19%)
SKIP6	NP_565522.1	F-box	21..64	CDD:279040	13/64 (20%)
		Kelch_1	117..160	CDD:279660	13/42 (31%)
		KELCH repeat	122..159	CDD:276965	10/36 (28%)
		muta_rot_YjhT	153..>352	CDD:274641	48/201 (24%)
		KELCH repeat	163..212	CDD:276965	15/48 (31%)
		Kelch_1	163..210	CDD:279660	15/46 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960