DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and GAN

DIOPT Version :10

Sequence 1:NP_650143.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_071324.1 Gene:GAN / 8139 HGNCID:4137 Length:597 Species:Homo sapiens


Alignment Length:593 Identity:154/593 - (25%)
Similarity:257/593 - (43%) Gaps:68/593 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 LSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAM 67
            :::.|.|.|.    :|......:...|:|..|   .||..|.::.:.....:.:|||..||....
Human     1 MAEGSAVSDP----QHAARLLRALSSFREESR---FCDAHLVLDGEEIPVQKNILAAASPYIRTK 58

  Fly    68 FTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACAS 132
            ...|..:.......::...|....:..:::|::|||:|::...:|:::..|..|.|::::..|..
Human    59 LNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCE 123

  Fly   133 FLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELN 197
            ||.......|.:|||.||.......:...|.:|::.:|..||.:||||.|..::|.|::..::||
Human   124 FLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLN 188

  Fly   198 VRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDE 262
            |..|..:|||.::|:.:..:.|......|::|:.:..|...:|.:::..|.|:      |:::.|
Human   189 VGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLV------REIVKE 247

  Fly   263 AKDFHLMPERRG--LLQSFRTRQRSGEFFTGQIYAVGGLASTGESVS---------TVEIYDPLT 316
            ..:..|...::|  :|.:|:.|.     ::..|..|||    .|.||         ...:|||..
Human   248 CSNIPLSQPQQGEAMLANFKPRG-----YSECIVTVGG----EERVSRKPTAAMRCMCPLYDPNR 303

  Fly   317 KKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFN-GTERLSTVEVYDPRKNKWSQGCAMLCKRSAVG 380
            :.|.....:||.|...||....|.|:.|||.: ..:.||:.|.|||..|.|:....|...|...|
Human   304 QLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFG 368

  Fly   381 VAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLS 445
            :..:|..:|:.||.||...|.::|.|...|.||.....:...|..|....:...:||:||.....
Human   369 IVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGK 433

  Fly   446 IFDSVERYDQAEDVWVKMSPMLNRR-----CRLGVATLNGKIYVCGGY-------------CGNS 492
            :|:|||.||.....|..:.|:..||     |  |||.   ::||.||.             |.:.
Human   434 LFESVECYDPRTQQWTAICPLKERRFGAVAC--GVAM---ELYVFGGVRSREDAQGSEMVTCKSE 493

  Fly   493 FLRSVECYDPQTDTWKLVTPMN----CKRSRVALAANMG-KLWAIGGYDGESNLSTVEVYDPETD 552
            |      |..:...|..:...|    ...|.|..|..:| .::.||..|..:|...|..:...|.
Human   494 F------YHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTG 552

  Fly   553 KWTFMPPM 560
            .|....|:
Human   553 TWHHTKPL 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_650143.1 BTB_POZ_KLHL18 20..137 CDD:349556 25/116 (22%)
PHA03098 36..510 CDD:222983 134/503 (27%)
KELCH repeat 329..372 CDD:276965 16/43 (37%)
KELCH repeat 376..417 CDD:276965 14/40 (35%)
KELCH repeat 423..466 CDD:276965 13/42 (31%)
KELCH repeat 470..514 CDD:276965 13/61 (21%)
Kelch_1 517..560 CDD:396078 11/43 (26%)
KELCH repeat 517..560 CDD:276965 11/43 (26%)
GANNP_071324.1 BTB_POZ_KLHL16_gigaxonin 16..126 CDD:349554 24/112 (21%)
PHA03098 27..502 CDD:222983 134/503 (27%)
BACK_KLHL16_gigaxonin 130..226 CDD:350530 29/95 (31%)
Kelch 1 274..326 16/55 (29%)
KELCH repeat 316..360 CDD:276965 16/43 (37%)
Kelch 2 327..374 15/46 (33%)
KELCH repeat 364..408 CDD:276965 14/43 (33%)
Kelch 3 376..421 13/44 (30%)
KELCH repeat 411..456 CDD:276965 14/44 (32%)
Kelch 4 422..468 17/47 (36%)
KELCH repeat 458..511 CDD:276965 14/63 (22%)
Kelch 5 470..522 11/57 (19%)
KELCH repeat 514..561 CDD:276965 12/47 (26%)
Kelch 6 528..574 8/33 (24%)

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