Protein Alignment KLHL18 and KLHL15

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_085127.2
• Gene: KLHL15 / 80311
• HGNCID: 29347
• Length: 604
• Species: Homo sapiens
• Alignment Length: 586
• Identity: 155/586 - (26%)
• Similarity: 259/586 - (44%)
• Gaps: 77/586 - (13%)

  Fly    18 HDKLFGESF-PLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEIT 81
            ||......| .|::|    |.|.||||.:||..|.||:.:||....||..|||.:|.|....:|.
Human    13 HDTSVSAGFRALYEE----GLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIH 73

  Fly    82 MKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGI 146
            :|  .:..:....::.::|.|.:.:....|..::..|.::||..|...|.|||:::....|...|
Human    74 LK--GLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEI 136

  Fly   147 RTFAD--SMICRQLIDAADKYIDQNFAKVSQSEEFLA-LDCEQLLELMRRDELNVRTEEVIFEAC 208
            ....|  .:....:.:..|.::..||..:....:||: |..|:|:..:..|.|:...|..::||.
Human   137 MRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAV 201

  Fly   209 MKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERR 273
            ..|::: :.:|......::..:|..|::|..:.::|...|..|.|.|.|..:|:|.::.....::
Human   202 QSWLRH-DRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQ 265

  Fly   274 GLLQSFRTRQRSGE----FFTGQIYAVGGLASTGESVSTVEIYDPLTKK----WKM-GEQMSMMR 329
            .||....:|.||.:    .|.|.|         |.|:...:|.  |.||    |:: |.|:.:..
Human   266 PLLDMKSSRIRSAKPQTTVFRGMI---------GHSMVNSKIL--LLKKPRVWWELEGPQVPLRP 319

  Fly   330 SRVGVAVLNGKLYAFGG--------FNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDD 386
            .  .:|::|..::..||        |:.:   |.|..||||:|.|.|...|...||...|..:..
Human   320 D--CLAIVNNFVFLLGGEELGPDGEFHAS---SKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGK 379

  Fly   387 CIYVCGGYDGVTSLNTVEVYYPKSNTWKTV--AQMMKYRSAGGVTQLNGYVYALGGHDGLS---- 445
            .||...|.....:..:.|.|...::.|:.|  ..:.||...|  |.||..::..||....|
Human   380 FIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEG--TVLNNKLFITGGITSSSTSKQ 442

  Fly   446 --IFD-----SVERYDQAEDV----WVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLR---- 495
              :||     ::|:..:...|    |...|.|...||...:.:.|||:||.||.|  ..||
Human   443 VCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVC--VILRASFE 505

  Fly   496 -----SVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGG--YDGESNLSTVEVYDPETDK 553
                 |.|.|:|:||.|.::..|...||...:.....::..:||  |:|..: .::..:||:.:|
Human   506 SQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYS-DSILTFDPDENK 569

  Fly   554 W 554
            |
Human   570 W 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	36/117 (31%)
		PHA03098	36..510	CDD:222983	139/519 (27%)
		KELCH repeat	329..372	CDD:276965	14/50 (28%)
		KELCH repeat	376..417	CDD:276965	10/42 (24%)
		KELCH repeat	423..466	CDD:276965	13/57 (23%)
		KELCH repeat	470..514	CDD:276965	19/52 (37%)
		Kelch_1	517..560	CDD:396078	10/40 (25%)
		KELCH repeat	517..560	CDD:276965	10/40 (25%)
KLHL15	NP_085127.2	BTB_POZ_KLHL15	1..137	CDD:349553	39/129 (30%)
		PHA03098	33..576	CDD:222983	147/562 (26%)
		BACK_KLHL15	128..235	CDD:350529	21/107 (20%)
		KELCH repeat	321..365	CDD:276965	14/46 (30%)
		Kelch 1	328..379		16/53 (30%)
		KELCH repeat	369..412	CDD:276965	10/42 (24%)
		Kelch 2	381..426		12/46 (26%)
		KELCH repeat	417..474	CDD:276965	14/58 (24%)
		Kelch 3	428..473		8/44 (18%)
		KELCH repeat	478..529	CDD:276965	19/52 (37%)
		Kelch 4	489..542		18/54 (33%)
		KELCH repeat	532..572	CDD:276965	10/40 (25%)
		Kelch 5	544..590		8/28 (29%)