DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and KLHL36

DIOPT Version :10

Sequence 1:NP_650143.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_079007.2 Gene:KLHL36 / 79786 HGNCID:17844 Length:616 Species:Homo sapiens


Alignment Length:582 Identity:159/582 - (27%)
Similarity:269/582 - (46%) Gaps:34/582 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDLSDNSQVEDQYFVYKHDKLF------GESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAA 59
            |:.|..::|...|.:.:..|::      ........|.|..|..|||.|..::|...|||.:||.
Human     2 MEGSRQTRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAV 66

  Fly    60 TIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLS 124
            ...||.:|||..|.|:..||:.:..::.  ..|:::::::|.|::.:|..|:..::..|..||:.
Human    67 CSDYFNSMFTIGMREAFQKEVELIGASY--IGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIW 129

  Fly   125 NVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLA-LDCEQLL 188
            .|.|.|..:|.......|.|.::..|.....::|....|.:|..:|..:|.:.:||. :..::|.
Human   130 TVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLC 194

  Fly   189 ELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRV--AREELIR 251
            ..:...|:....|..:.:|.::|:....::.:.. .|||..:..||:....|..||  |...|:.
Human   195 VYLSSSEVQRECEHDLLQAALQWLTQQPEREAHA-RQVLENIHFPLIPKNDLLHRVKPAVCSLLP 258

  Fly   252 SSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTG--ESVSTVEIYDP 314
            ....|...::||..:|.....:.::|:.||..|:.:   .::..|||..|..  |........|.
Human   259 KEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQ---ERLLFVGGEVSERCLELSDDTCYLDA 320

  Fly   315 LTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGF----NGTERLSTVEV-YDPRKNKWSQGCAMLC 374
            .:::|.....:...||...||||.|.::..||.    ||.:..|.:.. ||||..:|.:..:|..
Human   321 KSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQ 385

  Fly   375 KRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALG 439
            :|....:|:::|.:...||.:...:|::||.|.||:::|..||.:.::......|....:||..|
Human   386 RRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISG 450

  Fly   440 GHD---GLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGN--SFLR---- 495
            |||   | ....::..||...|||.:..||...|....:.:|...||..||...|  |..|    
Human   451 GHDYQIG-PYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVL 514

  Fly   496 SVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNL--STVEVYDPETDKWT 555
            .||.|.||.:.|..|.|:....|...:|...|:::.:|||..|:..  .||:|||.|.|||:
Human   515 GVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWS 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_650143.1 BTB_POZ_KLHL18 20..137 CDD:349556 35/122 (29%)
PHA03098 36..510 CDD:222983 134/492 (27%)
KELCH repeat 329..372 CDD:276965 17/47 (36%)
KELCH repeat 376..417 CDD:276965 12/40 (30%)
KELCH repeat 423..466 CDD:276965 13/45 (29%)
KELCH repeat 470..514 CDD:276965 17/49 (35%)
Kelch_1 517..560 CDD:396078 16/41 (39%)
KELCH repeat 517..560 CDD:276965 16/41 (39%)
KLHL36NP_079007.2 BTB_POZ_KLHL36 21..155 CDD:349575 37/135 (27%)
BACK_KLHL36 143..242 CDD:350550 20/99 (20%)
Kelch 1 296..345 13/48 (27%)
NanM 324..592 CDD:442289 81/254 (32%)
KELCH repeat 335..383 CDD:276965 17/47 (36%)
Kelch 2 346..397 13/50 (26%)
KELCH repeat 387..431 CDD:276965 14/43 (33%)
Kelch 3 398..444 12/45 (27%)
KELCH repeat 434..481 CDD:276965 15/47 (32%)
Kelch 4 446..493 16/47 (34%)
KELCH repeat 483..533 CDD:276965 17/49 (35%)
Kelch 5 494..546 17/51 (33%)
KELCH repeat 536..582 CDD:276965 16/41 (39%)
Kelch 6 547..595 13/30 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..616
Blue background indicates that the domain is not in the aligned region.

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